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Interactions between charged polypeptides and nonionic surfactants

The influence of molecular characteristics on the mutual interaction between peptides and nonionic surfactants has been investigated by studying the effects of surfactants on amphiphilic, random copolymers of alpha-L-amino acids containing lysine residues as the hydrophilic parts. The hydrophobic residues were either phenylalanine or tyrosine. The peptide-surfactant interactions were studied by me

NMR solution structure of calerythrin, an EF-hand calcium-binding protein from Saccharopolyspora erythraea

The structure of calerythrin, a prokaryotic 20 kDa calcium-binding protein has been determined by solution NMR spectroscopy. Distance, dihedral angle, J coupling, secondary chemical shift, residual dipolar coupling and radius of gyration restraints reveal four EF-hand motifs arranged in a compact globular structure. A tight turn in the middle of the amino acid sequence brings the two halves, each

Decreasing levels of tumour necrosis factor alpha and interleukin 6 during lowering of body mass index with orlistat or placebo in obese subjects with cardiovascular risk factors.

Aim: Obesity is associated with increased levels of inflammatory mediators. The objective of this study was to evaluate changes in the leucocyte derived inflammatory mediators tumour necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6) and the isoprostane 8-epi-prostaglandin (PG) F2alpha during BMI lowering with orlistat (Xenical®, Roche) or placebo. Methods: TNF-alpha, IL-6, and 8-epi PGF2alp

Significance of the dimensional view for visualizing relevant aspects of a production system in a co-operative planning process

Pictorial visualization is expected to facilitate communication between industrial professionals when planning working environments and production systems. This hypothesis was investigated by studying how 24 participants including managers, supervisors, machine operators, and occupational health and safety officials, judged three types of computer animated visualization varying in dimensional view

'Mediterranean Province' hyoliths from the middle Cambrian and Upper Ordovician of Sweden

Nine species of hyoliths are described based on material collected in Skane, southern Sweden, during the first half of the last century. The material derives from the middle Cambrian (Cambrian provisional Series 3) Exsulans Limestone Bed at Almbacken east of Lund and the Upper Ordovician (Katian-Hirnantian) Lindegard Formation at Tommarp west of Simrishamn. The Almbacken assemblage consists of thr

A brief conceptual tutorial of multilevel analysis in social epidemiology: linking the statistical concept of clustering to the idea of contextual phenomenon.

Study objective: This didactical essay is directed to readers disposed to approach multilevel regression analysis (MLRA) in a more conceptual than mathematical way. However, it specifically develops an epidemiological vision on multilevel analysis with particular emphasis on measures of health variation (for example, intraclass correlation). Such measures have been underused in the literature as c

Towards a Standard Methodology for Greenhouse Gas Balances of Bioenergy System in Comparison with Fossil Fuel System, Biomass and Bioenergy

In this paper, which was prepared as part of IEA Bioenergy Task XV (“Greenhouse Gas Balances of Bioenergy Systems”), we outline a standard methodology for comparing the greenhouse gas balances of bioenergy systems with those of fossil energy systems. Emphasis is on a careful definition of system boundaries. The following issues are dealt with in detail: time interval analysed and changes of carbon

CO2 utilization options .1. An emission assessment framework

The utilization of CO2 in various products and services must be carefully assessed in order to achieve reduced CO2 emissions and simultaneously to add to the net economic benefit of society. In this paper, a framework for the assessment of CO2 utilization options in the chemical industry is outlined in which the total CO2 emission is estimated in four steps. First, the processes under study are su

Exploring Bottlenecks in Market-Driven Requirements Management Processes with Discrete Event Simulation

This paper presents a study where a market-driven requirements management process is simulated. In market-driven software development, generic software packages are released to a market with many customers. New requirements are continuously issued, and the objective of the requirements management process is to elicit, manage, and prioritize the requirements. In the presented study, a specific requ

The 'Democraticness' of Multiparty Elections: Participation, Competition and Legitimacy in Africa

As the ‘third wave’ progressed it has been argued that democratisation should be analysed in terms of partial regimes rather than with multidimensional concepts of democracy. This article analyses the democratic qualities of one such partial regime, albeit arguably the core dimension of representative democracy: multiparty elections. The analysis focuses on the three basic democratic values of ele

Stochastic Dominance And Conditional Expectation - An Insurance Theoretical Approach

We show that the relation of second order stochastic dominance, which has found widespread use in models of economic behavior under uncertainty, may be described in terms of conditional expectation. If a distribution G second order stochastically dominates another distribution F, then there are random variables g and f with distributions G and F, respectively, such that g can be obtained from f by

Long-standing hyperglycemia in C57BL/6J mice does not affect retinal glutathione levels or endothelial/pericyte ratio in retinal capillaries

Free radicals have been suggested to play a role in the development of diabetic retinopathy. The aim of the present study was to examine whether the metabolic perturbations caused by high-fat feeding of two strains of mice, the C57BL6/J mice and the NMRI mice, interfere with one of the free radical enzyme defense systems in the retina, i. e., glutathione (GSH), and whether morphological changes oc