Mantle cell lymphoma (MCL) is associated with poor prognosis due to an aggressive clinical course. Being a raredisease, there are few randomized trials in MCL and there is no defined golden standard in primary treatment.This works aimed to (I) investigate outcome in relation to primary treatment in MCL based on population-basedregistry data, (II) to evaluate tolerability and efficacy of lenalidomiMantle cell lymphoma (MCL) is associated with poor prognosis due to an aggressive clinical course. Being a rare disease, there are few randomized trials in MCL and there is no defined golden standard in primary treatment. This works aimed to (I) investigate outcome in relation to primary treatment in MCL based on population-based registry data, (II) to evaluate tolerability and efficacy of lenalid

In the last years the use of information communication technologies (ICTs) has become a leading driver of OECD national health systems to improve healthcare quality and reduce healthcare costs (Oecd, 2010). In fact, the use of ICTs are a primary lever of OECD countries to enhance the efficiency and the effectiveness of health services delivered to the citizens. This has led the Italian government In the last years the use of information communication technologies (ICTs) has become a leading driver of OECD national health systems to improve healthcare quality and reduce healthcare costs (Oecd, 2010). In fact, the use of ICTs are a primary lever of OECD countries to enhance the efficiency and the effectiveness of health services delivered to the citizens. This has led the Italian government

One example of the welfare state’s health ambitions is to reduce the onset of illness and mortality from cancer, which among other things means that approximately 900,000 women in Sweden in the age group 40–74 years recurrently receive an invitation to mammography screening. The objective is to detect possible breast cancer at an early stage and thereby reduce mortality from the disease. For this

Much of identity formation processes nowadays takes place online, indicating that intergroup differentiation may be found in online communities. This paper focuses on identity formation processes in an open online xenophobic, anti-immigrant, discussion forum. Open discussion forums provide an excellent opportunity to investigate open interactions that may reveal how identity is formed and how indi

An experimental study has been carried out to investigate the effects of Coriolis force and centrifugal buoyancy force on convective heat transfer in a smooth cooling channel under rotating condition in a new rotation facility. The main motivation behind this work is to obtain required data for developing heat transfer correlations based on rotating state. In accordance with the open literature, f

Remodeling of the extracellular matrix (ECM) is a common feature in lung diseases such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). Here, we applied a sequential tissue extraction strategy to describe disease-specific remodeling of human lung tissue in disease, using end-stages of COPD and IPF. Our strategy was based on quantitative comparison of the dis

Muscular dystrophies, including laminin α2 chain-deficient muscular dystrophy (LAMA2-CMD), are associated with immense personal, social and economic burdens. Thus, effective treatments are urgently needed. LAMA2-CMD is either a severe, early-onset condition with complete laminin α2 chain-deficiency or a milder, late-onset form with partial laminin α2 chain-deficiency. Mouse models dy 3K /dy 3K

The Sendai Framework for Disaster Risk Reduction highlights the importance of all-hazard and multi-stakeholder approaches. This requires exchange and integration of risk information across sectorial and administrative borders. This paper focuses on challenges and prerequisites for aggregating risk information from multiple stakeholders in disaster risk management systems. Aggregation is here under

We present a novel computational technique intended for the robust and adaptable control of a multifunctional prosthetic hand using multichannel surface electromyography. The initial processing of the input data was oriented towards extracting relevant time domain features of the EMG signal. Following the feature calculation, a piecewise modeling of the multidimensional EMG feature dynamics using

Socioeconomic, ethnic and gender disparities in Chronic Obstructive Pulmonary Disease (COPD) risk are well established but no studies have applied multilevel analysis of individual heterogeneity and discriminatory accuracy (MAIHDA) within an intersectional framework to study this outcome. We study individuals at the first level of analysis and combinations of multiple social and demographic catego

Animal models of neurological deficits are essential to assess new therapeutic options and reduce treatment complications. Over the last decades, several rodent models of Parkinson's disease have been developed, and have now become the first-line experimental tool for therapeutic screening purposes. Which model is the most predictive for identifying the efficacy of symptomatic or disease-modifying

Dans la société contemporaine, l’accès et la dépendance accrus aux technologies numériques ont permis l'externalisation de la mémoire, ce qui représente un problème particulièrement important dans le contexte éducatif. Cet article cherche à rendre visible la façon dont les relations changent entre la recherche et la mémorisation de l'information à l’école, à partir d’une enquête menée auprès d’ens

The development of a high precision five rotation axes polarimeter using transmission multilayers as polarizers and reflection multilayers as analyzers is presented. In order to cover a wide energy range from EUV to soft X-ray, a set of Mo/Si, Cr/C, Sc/Cr, and W/B4C multilayers for transmission and reflection have been designed and fabricated. A hexapod support allows to align the polarimeter easi

Avhandlingen Naturliga medborgare undersöker hur frilfutsliv och lägerverksamhet använts som metoder för medborgarfostran i scoutrörelsen och Unga Örnar under perioden 1925–1960. Frågorna som undersökts innefattar hur organisationerna artikulerade ideal om medborgarskap, hur barn och ungdomar skulle fostras till goda medborgare samt mer specifikt hur natur och friluftsliv skulle bidra till att förThe aim of this thesis has been to examine outdoor activities and camping, framed within the Scandinavian notion of friluftsliv, as methods for promoting citizenship in two Swedish youth organisations: the Scout movement and Unga Örnar (“Young Eagles”). What knowledge and abilities characterised ideal citizenship; how was instruction in citzenship for children conducted and more specifically, how

This article presents the results of an interdisciplinary study combining archaeology, osteology, and stable isotope analyses. The geological conditions and richness of megalithic graves in Falbygden is suitable for studies of Neolithic human remains. Nevertheless, the Late Neolithic period (2350-1700 BC) is poorly investigated. This paper explores new knowledge of the Late Neolithic megalithic po

Human immunodeficiency virus type 1 (HIV-1) prevalence and incidence in the fishing communities on Lake Victoria in Uganda are high. This population may play a role in driving the HIV epidemic in Uganda including the spread of transmitted drug resistance (TDR). We report data on TDR in this population among antiretroviral (ARV)-naive, recently infected individuals about 5 years after ARV scaling-u

BACKGROUND: With the scale-up of antiretroviral therapy (ART), monitoring programme performance is needed to maximize ART efficacy and limit HIV drug resistance (HIVDR).METHODS: We implemented a WHO HIVDR prospective survey protocol at three treatment centers between 2012 and 2013. Data were abstracted from patient records at ART start (T1) and after 12 months (T2). Genotyping was performed in the

We investigated the rate of transmitted drug resistance (TDR) among HIV-1 seroconverters identified from the Rakai Community Cohort Study (RCCS) survey, a population-based cohort in Rakai District, Uganda. Participants aged 15-49 are interviewed at study visits approximately every 12-18 months and provided a serological sample. Antiretroviral therapy (ART) has been provided free of charge since 20