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Basiliolides, a class of tetracyclic C19 dilactones from Thapsia garganica, release Ca2+ from the endoplasmic reticulum and regulate the activity of the transcription factors nuclear factor of activated T cells, nuclear factor-kappa B, and activator protein 1 in T lymphocytes

Calcium concentration within the endoplasmic reticulum ER) plays an essential role in cell physiology. We have investigated the effects of basiliolides, a novel class of C19 dilactones isolated from Thapsia garganica, on Ca2+ mobilization in T cells. Basiliolide A1 induced a rapid mobilization of intracellular Ca2+ in the leukemia T-cell line Jurkat. First, a rapid calcium peak was observed and in

The impact of metabolic and blood pressure control on incidence and progression of nephropathy. A 10-year study of 385 type 2 diabetic patients

The aim of the present study was to find clinical parameters affecting incidence and progression of nephropathy in type 2 diabetic patients. A prospective study for 10 years was performed in 385 type 2 diabetic patients (diabetes diagnosis > or =30 years) attending a hospital-based outpatient clinic. Medical risk indicators like diabetes duration, HbA(1c), and blood pressure were related to the de

PHENIX on-line systems

The PHENIX On-Line system takes signals from the Front End Modules (FEM) on each detector subsystem for the purpose of generating events for physics analysis. Processing of event data begins when the Data Collection Modules (DCM) receive data via fiber-optic links from the FEMs. The DCMs format and zero suppress the data and generate data packets. These packets go to the Event Builders (EvB) that

Kyrka och nationalsocialism. [Review of four books]

Den första antologin har sin styrka i sina många exakta uppgifter (t. ex. om nedgången i antalet evangeliska teologistudenter under 1930-talet) och sina djupgående, teologiska analyser av det tyska materialet. Av den engelskspråkiga debatten, som möter i följande volym, märks dock inte mycket. Här får vi bl. a. veta att de amerikanska ledarna i World Jewish Congress 1941 krävde ett omedelbart stop

The influence of dough mixing time on wheat protein composition and gluten quality for four commercial flour mixtures

The effect of mixing time on wheat protein composition and gluten formation was studied for three commercial flour mixtures (biscuit, standard and strong) and one durum flour. Ultracentrifugation was used to separate the fresh, wet gluten from the wheat-flour dough immediately after mixing. Small deformation dynamic theological measurements and RP- and SE-HPLC were used to determine the characteri

Familial occurrence of microscopic colitis: a report on five families

BACKGROUND: The etiology and pathogenesis of microscopic colitis is unknown. Whether genetic predisposition is of importance, as in many other gastrointestinal diseases, is unknown. Familial occurrence of collagenous colitis has earlier been reported only in two families. METHODS: Familial occurrence of microscopic colitis was searched for in a Swedish national microscopic colitis register. RESULT

Development of Detector Systems for Internal and Fixed Target Heavy Ion Physics Experiments

This thesis deals with intermediate energy heavy ion reactions with the particular aim to study the nuclear matter equation of state which defines the relation between statistical parameters of a fermionic system. The development of equipment for two experiments, CA47 at The Svedberg Laboratory in Uppsala, Sweden and R16 at Kernfysisch Versneller Instituut (KVI), Groningen, The Netherlands, are d

Asian Models of Agricultural Development and their Relevance to Afrika

This working paper discusses the different Asian experiences of the Green Revolution from the late 1960s to the 1980s in the perspective of earlier developments of agricultural intensification. The intention of the paper is to identify common features and conditions contributing to the considerable success of Asian agriculture over the past 30 years. The authors argue that the Green Revolution mus

Undervisning i konsultationsmetodik behövs i läkarutbildningen. Utvärdering med studentenkät och fokusgruppsintervjuer

Inom läkarutbildningen vid Lunds universitet förekommer undervisning i samtalsmetodik under såväl den prekliniska som den kliniska delen. Under kursen i samhällsmedicin på termin 10 träffas grupper om sex till sju studenter och en gruppledare fyra gånger för att diskutera studenternas videoinspelade konsultationer. Vi har utvärderat detta moment genom en klassrumsenkät till samtliga studenter och At Lund University Medical School communication skills are taught during both the preclinical and clinical part of the medical programme. As part of the training during the 5th year the students are required to videotape at least one patient consultation at a local primary health care centre. The students then meet in groups of 6-7 participants and a group leader to watch the recorded consultation

New structural chromosomal rearrangements in congenital leukemia

The karyotypic abnormalities and clinical data on three patients in whom acute leukemia was diagnosed within the first 6 months of life are presented. The four structural chromosomal rearrangements detected in the bone marrow from these patients, i.e., t(7;12)(q36;p13) and t(1;19)(q11;q11) in case 1, t(2;10;11;12)(q21q31;p13;q13;q24) in case 2, and t(11;19)(q23;p13) in case 3, have not previously

Carriage of penicillin-resistant Streptococcus pneumoniae by children in day-care centers during an intervention program in Malmo, Sweden

BACKGROUND: An increasing incidence of penicillin-resistant Streptococcus pneumoniae (PRP) was detected in Malmo in 1994. OBJECTIVE: To evaluate clonality and factors facilitating the spread of PRP among children in day-care centers (DCCs). METHODS: We used phenotypic and DNA-fingerprinting methods in conjunction with epidemiologic data from the South Swedish Pneumococcal Intervention Project's in

Measurements of the interaction cross sections for Ar and Cl isotopes

We have measured the interaction cross sections (σI) of 31–40Ar and 31–37Cl on carbon targets at energies of around 950 A MeV. The effective matter radii for these nuclei were deduced by a Glauber-model analysis. Combining our matter radii with measured charge radii for Ar isotopes, we could deduce the proton-skin thicknesses for the 32–40Ar isotopes, which were found to increase monotonically wit

A fishy mosasaur: the axial skeleton of Plotosaurus (Reptilia, Squamata) reassessed

The concept of convergence, that is, how unrelated animals independently evolve similar morphological traits, is a fundamental aspect of evolution. Hitherto, the Mesozoic ichthyosaurs were regarded as the sole obligate marine reptiles that achieved a fully streamlined body and a semilunate tail fluke. However, analyses of vertebral centrum morphometrics and process orientation have revealed that a