Microparticles (MP) are small (100-1000 nm) membrane vesicles shed by cells as a response to activation, stress or apoptosis. Platelet-derived MP (PMP) has been shown to reflect the pathophysiological processes of a range of cardiovascular diseases and there is a potential clinical value in using PMPs as biomarkers, as well as a need to better understand the biology of these vesicles. The current

Engineers in large-scale software development have to manage large amounts of information, spread across many artifacts. Several researchers have proposed expressing retrieval of trace links among artifacts, i.e. trace recovery, as an Information Retrieval (IR) problem. The objective of this study is to produce a map of work on IR-based trace recovery, with a particular focus on previous evaluatio

We present new major and trace element data, as well as Sm–Nd isotope compositions for Archaean supracrustal rocks and a gabbro-anorthosite complex from the island of Storø in Godthåbsfjord, southern West Greenland. We also provide new U–Pb isotope data for zircon extracted from these rocks. The Storø rocks have experienced amphibolite facies metamorphism, and the entire sequence forms an east-dip

OBJECTIVE: To compare robot-assisted laparoscopy and laparotomy for radical hysterectomy and pelvic lymphadenectomy in terms of hospital costs. METHODS: Consecutive women undergoing radical hysterectomy and pelvic lymphadenectomy as a sole procedure between January 2001 and February 2012 were included. We compared OR times, hospital stay, procedure specific costs, blood transfusions and cost for r

We examine here the hypothesis that during flowering, the grass pollen concentrations at a specific site reflect the distribution of grass pollen sources within a few kilometres of this site. We perform this analysis on data from a measurement campaign in the city of Aarhus (Denmark) using three pollen traps and by comparing these observations with a novel inventory of grass pollen sources. The so

There is growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, to date no epidemiological study has investigated the influence of the MD on bladder cancer. We evaluated the association between adherence to the MD and risk of urothelial cell bladder cancer (UCC), according to tumor aggressiveness, in the European Prospective Investigation into Cancer and Nutriti

In this article we respond to Bargiela-Chiappini, Iedema and Mumby.We notice that there is considerable agreement concerning the state of the art of organizational discourse analysis, while also discussing the disagreements. We expand on some of the ontological issues inherent in our argument, further discuss the character of reductionism in organizational discourse analysis, the trappings of a pr

Bone marrow-derived mesenchymal stromal cells (MSCs) target glioma extensions and micro-satellites efficiently when implanted intratumorally. Here, we report that intratumoral implantation of MSCs and peripheral immunotherapy with interferon-gamma (IFNγ) producing tumor cells improve the survival of glioma-bearing rats (54% cure rate) compared to MSC alone (0% cure rate) or immunotherapy alone (21

In the Iberian Peninsula, populations of two subspecies of the Reed Bunting Emberiza schoeniclus have become increasingly fragmented during the last decades when suitable habitats have been lost and/or the popula- tions have gone extinct. Presently, both subspecies are endangered. We estimated the amount of genetic variation and population structure in order to define conservation units and manage

The debate about post-2012 global climate governance has been framed largely by proponents and opponents of the policymaking process established by the United Nations Framework Convention on Climate Change (UNFCCC). In light of the proliferation of institutions governing some aspects of climate change, analysts have asked whether a centralized or a polycentric climate governance architecture will

The visual systems of many animals feature energetically costly specializations to enable them to function in dim light. It is often unclear, however, how large the behavioural benefit of these specializations is, because a direct comparison in a behaviourally relevant task between closely related day- and night-active species is not usually possible. Here we compared the orientation performance o

Dietary flavanols and flavonols, flavonoid subclasses, have been recently associated with a lower risk of type 2 diabetes (T2D) in Europe. Even within the same subclass, flavonoids may differ considerably in bioavailability and bioactivity. We aimed to examine the association between individual flavanol and flavonol intakes and risk of developing T2D across European countries. The European Prospec

The effects of Al layers deposited on graphene grown on C-face SiC substrates are investigated before and after subsequent annealing using low energy electron diffraction (LEED), photoelectron spectroscopy, and angle resolved photoemission. As-deposited layers appear inert. Annealing at a temperature of about 400 degrees C initiates migration of Al through the graphene into the graphene/SiC interf

Oblivious to ion specificity, pH has been a key parameter for macromolecular solutions for little more than a century. We here widen the concept by describing the ionization of macromolecules not only via pH, but also pX where X are other binding species. Using binding constants, measured by NMR, of chloride and thiocyanate to amino acid motifs on g-crystallin, we calculate i) titration curves as

Glucagon was discovered in 1922 as a hyperglycemic factor in the pancreas. During its early history up to 1970, glucagon was shown to increase circulating glucose through stimulating glycogenolysis in the liver. It was also shown to be a constituent of islet non-ß cells and to signal through G protein coupled receptors and cyclic AMP. Furthermore, its chemical characteristics, including amino acid

Secretion of outer membrane vesicles (OMV) is an intriguing phenomenon of Gram-negative bacteria and has been suggested to play a role as virulence factors. The respiratory pathogens Moraxella catarrhalis reside in tonsils adjacent to B cells, and we have previously shown that M. catarrhalis induce a T cell independent B cell response by the immunoglobulin (Ig) D-binding superantigen MID. Here we

The purpose of the study was to evaluate how breathing motion during tomotherapy (Accuray, CA, USA) treatment affects the absorbed dose distribution. The experiments were carried out using gel dosimetry and a motion device simulating respiratory-like motion (HexaMotion, ScandiDos, Uppsala, Sweden). Normoxic polyacrylamide gels (nPAG) were irradiated, both during respiratory-like motion and in a st

The paper aims to elucidate in better detail than before the dispute about whether or not dispositional monism—the view that all basic properties are pure powers—entails a vicious infinite regress. Particular focus is on Alexander Bird’s and George Molnar’s attempts to show that the arguments professing to demonstrate a vicious regress are inconclusive because they presuppose what they aim to prov