Degeneration of the locus ceruleus (LC) and decreased cortical levels of norepinephrine are common findings in Alzheimer's disease (AD), but their significance is unknown. Because the noradrenergic system is accessible to pharmacological intervention, the role of LC degeneration and noradrenergic dysfunction in the pathogenesis and clinical manifestations of AD needs clarification. Hypothetically,

It is well-known that Toeplitz operators on the Hardy space of the unit disc are characterized by the equality , where S1 is the Hardy shift operator. In this paper we give a generalized equality of this type which characterizes Toeplitz operators with harmonic symbols in a class of standard weighted Bergman spaces of the unit disc containing the Hardy space and the unweighted Bergman space. The o

The first Scandinavian protocol for Ewing's sarcoma, SSG IV, resulted in a local control rate of 74% and 5-year metastasis-free survival (MFS) of 43%. The second protocol, SSG IX, was started in order to improve upon these results. It featured four chemotherapy cycles, each consisting of two courses of VAI (vincristine, doxorubicin, ifosfamide) alternating with one course of PAI (cisplatin, doxoru

Objective: Osteoarthritis (OA) biomarkers are needed by researchers and clinicians to assist in disease diagnosis and assessment of disease severity, risk of onset, and progression. As effective agents for CA are developed and tested in clinical studies, biomarkers; that reliably mirror or predict the progression or amelioration of CA will also be needed. Methods: The NIH-funded CA Biomarkers Netw

The spatial dispersion and social interactions were studied in I I neighbouring pairs of radio-tagged tawny owls Strix aluco in a deciduous wood in Denmark from 1998-2001. The numbers and shapes of territories were stable throughout the survey and similar to a mapping made 40 years earlier. The home ranges of mates were of equal size and overlapped 82% in summer and 56% in winter. The inter-mate d

A new laminar flamelet model is presented for Large Eddy Simulation ( LES) of premixed turbulent combustion. The model uses a marker field S+ to capture the flame. Compared to previous work on marker fields, a modification was introduced to simplify the boundary conditions. Although the scalar S+ is smooth in space, it allows describing steep flame fronts. The S+ equation captures the laminar or t

Purpose A Japanese randomized trial showed superior survival for patients with extensive-disease (ED) small-cell lung cancer (SCLC) receiving irinotecan plus cisplatin compared with etoposide plus cisplatin. The present trial evaluated the efficacy of irinotecan plus carboplatin (IC) compared with oral etoposide plus carboplatin (EC). Patients and Methods Patients with ED SCLC were randomly assign

This study investigates exposure to polybrominated diphenyl ethers (PBDEs) and tetrabromobisphenol A (TBBPA), which are used as flame retardants in electronic equipment, in a group of technicians with intense computer work. Thirteen PBDE congeners and TBBPA were quantified in serum from 19 computer technicians. Previously investigated groups of hospital cleaners with no computer experience, and cl

Fine-needle aspiration (FNA) features in 10 angioleiomyomas (ALM) were evaluated and correlated to histological features and clinical data. The tumors developed in the skin or subcutaneous tissue of the lower extremities (eight), the shoulder (one), and the lower arm (one). Eight tumors were painful or tender. Cytological specimens showed moderate or sparse cellularity. The most frequent findings

A natural summer phytoplankton community from the Gullmar Fjord (Skagerrak, Swedish west coast) was diluted 10 times with filtered seawater in twelve 300-dm(3) polyethylene cylinders. Nutrients were added to produce two different molar ratios of nitrogen to silicon (N/Si 3.2/3.2 mu M=1 and 12.8/3.2 mu M=4). Three cylinders of each nutrient treatment were carefully mixed while the other three of ea

Background: Previous studies support a role of oxygen-free radicals in the development of congestive heart failure (CHF). The aim of this study was to investigate whether lipid peroxidation is increased in CHF patients on modem pharmacological therapy and whether there is a positive correlation between plasma levels of markers of lipid peroxidation and severity of heart failure (HF). Plasma malond

We followed a population-based cohort of 5696 women, 32 - 38 years of age, by registry linkage with cytology and pathology registries during a mean follow-up time of 4.1 years to assess the importance for CIN2 + development of type-specific HPV DNA positivity at baseline. HPV 16, 31 and 33 conveyed the highest risks and were responsible for 33.1, 18.3 and 7.7% of CIN2 + cases, respectively. Women

OBJECTIVES: The aim of this study was to evaluate the applicability of total plasma protein adducts (TPPA) of 2 sensitizing low-molecular-weight allergens, hexahydrophthalic anhydride (HHPA) and methylhexahydrophthalic anhydride (MHHPA), as biomarkers of long-term exposure. METHODS: Urine samples from occupationally exposed workers were analyzed for the levels of urinary metabolites of HHPA and MH

Adrenocorticotrophic hormone (ACTH) at pharmacological dosage has marked lipid-lowering effects that may have therapeutic implications. The rationale behind the present investigation was the possible use of ACTH as a lipid-lowering replacement for steroids. Thirty-two healthy individuals were randomly divided into four groups of 8 each. Three ACTH groups received different doses of ACTH(1-24) intr

The Hyttsjo granites occur in the extensively mineralised Langban-Nordmark area in the westernmost part of the Bergslagen ore province. They have been classified as late Svecokarelian granites due to their homogeneous and generally isotropic appearance in addition to a WR Rb/Sr age. Moreover, they have been considered as possible candidates for supplying essential metals to epigenetic mineralisati

A thermoseparating aqueous two-phase system for extraction of a recombinant cutinase fusion protein from Escherichia coli homogenate has been scaled up to pilot scale. The target protein ZZ-cutinase-(WP)4 was produced in a fed batch process at 500 l to a concentration of 12% of the total protein and at a cell concentration of 19.7 g l-1. After harvest and high-pressure homogenisation a first extra