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In recent years, Predictive Digital Twins (PDT) have emerged as a potential tool to monitor and predict the behavior of dynamic systems, including nature-based solutions in natural coastal systems. Here, we test the potential of using a simple, coupled shoreline and beach-dune model as a base for a PDT. The models exchange sediment flux balance information at each time step and recalculate shoreli

OBJECTIVE: To assess structural changes at peripheral entheses and the association with spinal bone formation in patients with long-standing radiographic axial spondyloarthritis (r-axSpA) overall and stratified by sex. METHODS: Peripheral entheses were examined cross-sectionally using ultrasound (US) in patients fulfilling the modified New York criteria for ankylosing spondylitis (AS) and assessed

We present a genome assembly from a male specimen of Zethes insularis (Arthropoda; Insecta; Lepidoptera; Erebidae). The assembly contains two haplotypes with total lengths of 862.07 megabases and 869.20 megabases. Most of haplotype 1 (99.0%) is scaffolded into 31 chromosomal pseudomolecules, including the Z sex chromosome. Most of haplotype 2 (95.76%) is scaffolded into 31 chromosomal pseudomolecu

Urban areas are increasingly exposed to extreme precipitation events, which can disrupt critical infrastructure and damage the built environment. While flood impacts are often assessed separately for buildings or road networks, this study analyses both flood-induced road inaccessibility and building flood risk in Gothenburg using a climate-adjusted 100-year rainfall at both the city scale and the

Lung transplantation (LTx) remains the only curative treatment for patients with end-stage lung disease, yet long-term outcomes remain inferior to those of other solid organ transplantations, with a 5-year survival below 70%. Major contributors to this limited outcome include primary graft dysfunction (PGD), the leading cause of early mortality, chronic lung allograft dysfunction (CLAD), and low u

Based on ten months of research at an elite university in Beijing (Qinghua University) this article focuses on the conundrums of life for young people in China today. It addresses the paradoxical situation faced by many young people, who are among the lucky few, who have made it to the top of a very competitive educational system yet feel deeply ambivalent about their own futures. Through a detail

This article is based on anthropological fieldwork undertaken at two elite universities in Beijing. It addresses the paradoxical situation of the many instances of suicide among Chinese elite university students in Beijing, which constitute a public secret. The pressure of education weighs heavily on the shoulders of China’s only child in each family, known as the generation of little emperors and

Malaria caused by Plasmodium falciparum (P. falciparum) remains a major cause of morbidity and mortality, particularly in sub-Saharan Africa. Immunity develops gradually after repeated exposure and is largely mediated by antibodies, yet the mechanisms regulating the development and function of humoral immunity, including the roles of B-cell subsets and inflammatory mediators, remain incompletely u

Opioider, som är ett narkotiskt läkemedel med mycket effektivt smärtlindrande effekt vid akuta smärttillstånd och i samband med smärtsamma ingrepp i dagens sjukvård. Under många år har opioider också använts för att behandla långvarig smärta som inte beror på cancer. Det finns risker med en sådan behandling då den kan leda till beroende och överdos. Samtidigt saknas bevis för att opioider lindrar

Siden starten af det 20. århundrede har Shanghai haft status som Kinas mest vestliggjorte by. På grund af Shanghais placering som Kinas vigtigste havneby og indgangsport til Kina for den øvrige verden har byen været hjemsted for den handelsmæssige og den intellektuelle elite

Background: This is one of the few European studies of self-management and self-monitoring during the initial two weeks following discharge after open cardiac surgery. Typical outcomes are mortality, morbidity, surgical complications and additional medical treatment. Equally important for enabling person-centred care are the patients’ perspective and main concerns. The aim was to explore feasibili

Förbättring av Krämer för Fotodynamisk Behandling av Hudcancer Fotodynamisk terapi (PDT) är en modern och relativt skonsam behandlingsmetod som används vid vissa typer av hudcancer och förstadier till hudcancer. I stället för att operera bort vävnad används ett ljuskänsligt läkemedel som appliceras på huden. När det behandlade området belyses med ljus av en specifik våglängd reagerar läkemedlet mePhotodynamic therapy (PDT) is an established treatment for actinic keratosis and selected non-melanoma skin cancers. Still, its broader use is limited by pain, skin irritation, and formulation constraints associated with high photosensitiser concentrations. This study aimed to develop and evaluate a Crystalip®-based topical PDT formulation that enables two-step manufacturing, delivers methyl-amino