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Background: This phase II study evaluated the safety and activity of ipilimumab, a fully human mAb that blocks cytotoxic T-lymphocyte antigen-4, in patients with advanced melanoma. Patients and methods: Patients with previously treated, unresectable stage III/stage IV melanoma received 10 mg/kg ipilimumab every 3 weeks for four cycles (induction) followed by maintenance therapy every 3 months. The

Populärvetenskaplig artikel om Finland under andra världskriget.

Ethnologists like to think of themselves as masters of the study of the everyday, but we still know surprising little how this mundane machinery works. Everyday life remains something of a black box, our understanding is still piecemeal and fragmented. This paper explores cohabitation and circulation of objects, affects and activities in the home - seen as a workshop where raw materials, raw feeli

Inbreeding depression is a key factor influencing mating system evolution in plants, but current understanding of its relationship with selfing rate is limited by a sampling bias with few estimates for self-incompatible species. We quantified inbreeding depression () over two growing seasons in two populations of the self-incompatible perennial herb Arabidopsis lyrata ssp. petraea in Scandinavia.

Aims: The general objective was to further elucidate thromboembolic disease in children and thereby help improve the care of these patients. More specific aims were as follows: to determine what children are affected by thrombosis; to discern any gender or age differences related to thrombosis; to identify prothrombotic risk factors; to ascertain whether autoantibodies against coagulation proteins

Studies on growth of the small intestine have mostly concentrated on crypt hyperplasia rather than crypt fission (CF). The process of crypt bifurcation has been identified in rodents and humans but not in swine. The main aims of this study were: 1) to investigate quantitatively crypt fission in the small intestine mucosa of pigs of different age-groups and 2) to assess the effect of colostrum and

We study the properties of impersonal null-subjects, in particular in Icelandic, exploring the idea that such elements are constructed in syntax (rather than being lexical pronouns deleted in PF). In addition, we discuss the cross-linguistic distribution of impersonal null-subjects.

Enflo K. and Hjertstrand P. Relative sources of European regional productivity convergence: a bootstrap frontier approach, Regional Studies. This paper addresses the issue of Western European regional productivity growth and convergence by means of data envelopment analysis (DEA), decomposing labour productivity into efficiency change, technical change and capital accumulation. The decomposition s

A search for the Standard Model Higgs boson in the H -> WW(*()) -> lvlv (l = e.mu) decay mode is presented. The search is performed using proton-proton collision data corresponding to an integrated luminosity of 4.7 fb(-1) at a centre-of-mass energy of 7 TeV collected during 2011 with the ATLAS detector at the Large Hadron Collider. No significant excess of events over the expected background is o

With the continued growth of digital services offering storage and communication of pictorial information, the need to efficiently represent this information has become increasingly important, both from an information theoretic and a perceptual point of view. There has been a recent interest to design systems for efficient representation and compression of image and video data that take the featu

Extensive measurements of soil surface (including vegetation cover) CO2 efflux were carried out on 80 positions at four different forest sites (Sweden, Germany, Czech Republic and Italy) using a closed dynamic chamber technique. The period of measurement was 4-5 consecutive days per site. Two approaches were used to analyze the measured data, the Q(10) parameter and the Arrhenius relationship. Bas

Ion channels and ion fluxes control many aspects of tissue homeostasis. During oncogenic transformation, critical ion channel functions may be perturbed but conserved tumor specific ion fluxes remain to be defined. Here we used the tumoricidal protein-lipid complex HAMLET as a probe to identify ion fluxes involved in tumor cell death. We show that HAMLET activates a non-selective cation current, w

National framework conditions directly affect the productivity of firms, but also moderate returns on their technological efforts. Although this has long been recognised, there is a dearth of quantitative analyses that openly consider this hypothesis. Using a data set of 15 425 manufacturing firms in 32 developing countries, we investigate the impact of national institutions on firms' total factor

Popular Abstract in Swedish Förlossnings- och barnläkare har i många år sökt efter ett instrument för utvärdering av det nyfödda barnets hälsotillstånd. Virginia Apgar introducerade 1953 ett poängsystem som bygger på en subjektiv bedömning av barnets hudfärg, hjärtfrekvens,reflexer/retbarhet, muskeltonus och andning. Koncentrationen i blodet av olika gaser, syror och baser speglar också det nyföddAcid-base status in umbilical cord blood is an objective measure of the fetus’ exposure to and ability to handle hypoxia. The objective of this thesis was to clarify some of the methodological pitfalls in interpreting umbilical cord blood gases and lactate values at birth. Study I pinpoints the methodological confounding in calculating base deficit (BD) with algorithms used in different brands of

Aims. Until recently, most high-resolution spectroscopic studies of the Galactic thin and thick discs were mostly confined to objects in the solar vicinity. Here we aim at enlarging the volume in which individual chemical abundances are used to characterise the thin and thick discs, using the first internal data release of the Gaia-ESO survey (GES iDR1). Methods. We used the spectra of around 2000