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Background: People with early axial spondyloarthritis experience a diagnostic delay and a similar disease burden as people with axial spondyloarthritis at a later stage of the disease. In many European countries, patients with early axial spondyloarthritis do not have access to an interdisciplinary rehabilitation team. The objective of this study was to develop a new evidence-based physiotherapist

Diderot's Encyclopédie is a reference work from XVIIIth century in Europe that aimed at collecting the knowledge of its era. Wikipedia has the same ambition with a much greater scope. However, the lack of digital connection between the two encyclopedias may hinder their comparison and the study of how knowledge has evolved. A key element of Wikipedia is Wikidata that backs the articles with a grap

Mammalian vocalisations are extremely diverse, and evolutionary approaches to understanding this diversity assume that much of their acoustic form maps onto their function, with specific features serving universal roles. Here, we hypothesize that nonlinear phenomena (i.e., deterministic chaos, sidebands, subharmonics, and frequency jumps), which make the voice perceptually rough or harsh, contribu

X-ray multi-projection imaging (XMPI) is an emerging experimental technique for the acquisition of rotation-free, time-resolved, volumetric information on stochastic processes. The technique is developed for high-brilliance light-source facilities, aiming to address known limitations of state-of-the-art imaging methods in the acquisition of 4D sample information, linked to their need for sample ro

Purpose: Complications from diabetes mellitus can occur over time and although glycosylated hemoglobin (HbA1c) is a good biomarker for glycaemic control, other factors also contribute to the development of complications in type 1 diabetes. More markers able to identify the risk of complications are needed. This study aimed to investigate plasma levels of FGF21, Cystatin C, lipocalin-2, and MMP-9 i

A cell’s ability to sense and respond to mechanical cues from its extracellular environment is essential for maintaining the health of itself and its organism. The mechanical cues a cell encounters include physical forces such as shear, tensile, and compressive forces, as well as cues arising from the mechanical properties of the extracellular matrix (ECM), such as stiffness or composition. Throug

We uncover the occurrence of shear banding in dense suspensions of compressible microgels. Velocimetry measurements evidence the presence of permanent but unsteady shear-banding for sufficiently small Peclet numbers, with the formation of a central plug-like flow. Small-angle neutron scattering experiments under shear link the observed banding phenomenon to structural variations along the velocity

We consider the most energetically favorable symmetry-allowed spin-singlet and spin-triplet superconducting pairing symmetries in twisted bilayer graphene at the magic angle, whose normal state physics is described by a six-band effective tight-binding model. We compute the Chern number as a function of the superconducting order parameter strength and the chemical potential and we find a topologic

Background: Calcineurin inhibitors (CNIs) are associated with long-term complications after heart transplantation (HTx). Everolimus (EVR)-based immunosuppression allows for CNI withdrawal. We used data from The Scandinavian heart transplant everolimus de novo study with early CNI avoidance (SCHEDULE) trial to assess whether health-related quality of life (HRQoL) differed between patients on long-t

In recent years, remote sensing data have revealed considerable potential in unraveling crucial information regarding water balance dynamics due to their unique spatiotemporal distribution characteristics, thereby advancing multi-objective optimization algorithms in hydrological model parameter calibration. However, existing optimization frameworks based on the Soil and Water Assessment Tool (SWAT

In this work, we present results of numerical simulations of the formation and early evolution of rocky planets through pebble accretion, with an emphasis on hydrogen envelope longevity and the composition of the outgassed atmosphere. We modelled planets with a range in mass from 0.1 to 5 Earth masses that orbit between 0.7 and 1.7 AU. The composition of the outgassed atmosphere was calculated wit

Background: SepIVA has been reported to be an essential septation factor in Mycolicibacterium smegmatis and Mycobacterium tuberculosis. It is a coiled-coil protein with similarity to DivIVA, a protein necessary for polar growth in members of the phylum Actinomycetota. Orthologues of SepIVA are broadly distributed among actinomycetes, including in Streptomyces spp. Results: To clarify the role of S

Context. The Gaia-Sausage-Enceladus merger was a major event in the history of the Milky Way. Debris from this merger has been extensively studied with full kinematic data from the Gaia mission. Understanding the star formation history of the progenitor galaxy aids in our understanding of the evolution of the Milky Way and galaxy formation in general. Aims. We aimed to constrain the star formation

Background and aim: The popularity of remote and blended teachings in physiotherapy higher education is increasing. Initial evidence suggests that these methods are as effective as face-to-face teaching for theoretical and practical skill learning in physiotherapy; however, further research is required. Methods: This was a retrospective comparative study. Three groups of physiotherapy students und

Legislatures are a key institution in modern political systems. They control the executive: in parliamentary systems, they elect the government, and in presidential systems, they often approve the members of the cabinet who were appointed by the president. Moreover, legislatures and their committees are the main bodies in a political system in which new policies - in the form of law proposals - ar

CD59 is a cell-surface inhibitor of the terminal step in the complement cascade. However, in addition to its complement inhibitory function, a non-canonical role of CD59 in pancreatic beta cells has been identified. Two recently discovered intracellular alternative splice forms of CD59, IRIS-1 and IRIS-2, are involved in insulin exocytosis through interactions with SNARE-complex components. In mic

BACKGROUND: Participation in everyday life and personal recovery is often adversely affected for individuals with complex mental health needs. Flexible Assertive Community Treatment (FACT) is a recovery-oriented service targeting participation in everyday life and personal recovery and is thus important to understand from the perspectives of service users.AIM: To explore how service users experien

Micro-society experimental setups are increasingly used to infer aspects of human behavioural evolution. A key part of human society today is our dependence on, and use of, technology–whether simple (such as a knife) or complex (such as the technology that underpins AI). Previously, two groups of researchers used an abstracted-wheel experiment to explore the evolution of human technical behaviour,

Carbon capture and storage technologies (CCS) are being discussed and tested in different countries to reduce industrial emissions. Public opinion about industrial CCS (iCCS) can be a key factor in whether it will be implemented. Yet, measuring public acceptance of CCS is a challenge: on the one hand, the use of CCS is the subject of intense and controversial political debate. On the other hand, a

Decoherence of a charge qubit is usually credited to charge noise in the environment. Here we show that charge noise may not be the limiting factor for the qubit coherence. To this end, we study coherence properties of a crystal-phase defined semiconductor nanowire double quantum dot (DQD) charge qubit strongly coupled to a high-impedance resonator using radio-frequency reflectometry. Response of