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The neutral protease cathepsin G belongs to a family of hematopoietic serine proteases stored in the azurophil granules of the neutrophil granulocyte. To investigate the function of asparagine-linked carbohydrates in neutrophil serine proteases, we constructed a mutant cDNA, coding for human cathepsin G deficient of a functional glycosylation site, for use in a transgenic cellular model. Wild type

Introduction: The Person-Centred Care instrument for outpatient care (PCCoc) is a 36-item patient-reported experience measure with 4 ordered response categories, that aims to capture the degree of perceived person-centred care (PCC) from a patient perspective among persons with long-term conditions. The PCCoc is based on a framework that conceptualises outpatient PCC from lower to higher levels of

Background: Turner syndrome (TS) is a complex genetic disorder with raised mortality. Our objective was to investigate mortality and causes of death in TS. Methods: A matched retrospective observational study of women with TS recruited from the Turner centers in Sweden were conducted. A total of 472 women with TS, ≥16 years old with a cytogenetically verified diagnosis and 2357 controls, matched f

The automatic activation of spatial representations of affect has mainly been studied using stimuli at the extreme ends of the valence continuum, such as happy and angry facial expressions (e.g., Damjanovic & Santiago, 2016). It remains unclear whether the 'up = good' metaphor can also be triggered by stimuli with subtle valence. This issue was investigated in the current series of visual sear

Understanding the initial oxidation pathways on binary Ni-Cr surfaces is import for alloy development and rational design. The early-stage oxidation of Ni-22wt% Cr is studied in-situ and in-operando with synchrotron-based x-ray photoelectron microscopy (XPEEM) and x-ray photoelectron spectroscopy (XPS) at 500 °C and oxygen exposure from 0 to 65 Langmuir. Preferential Cr oxidation is accompanied by

Three fine grained WC-10 vol% Co cemented carbide materials were produced. One with 1 w% Cr addition, one with 0.025 w% Ti addition and one with both additions of 1 w% Cr and 0.025 w% Ti. It was found that doping of both Cr and Ti is advantageous for grain growth inhibition over just Cr- or Ti-doping. The impact of Cr and Ti as grain growth inhibitors on the residual stress state after sintering w

Cubosomes have emerged as a powerful platform for cancer treatment due to their biocompatibility and ability to encapsulate hydrophilic/lipophilic drugs, providing controlled drug release. While investigating these nanoparticles' stability and intracellular localization is essential for advancing them as clinically efficient nanomedicine, such studies are still lacking, and those available do not

In this short paper, we reflect on ‘algorithmic management learning’ – a phenomenon that dates back to the early twentieth century but has gained fresh impetus in the dawning age of artificial intelligence. In particular, we suggest that management learning has today become a human-machine hybrid. This form of management learning is not only increasingly non-reflexive, it is also impeding the huma

The ruling paradigm is that future climate change scenarios will lead to an increase in the frequency, intensity, and duration of cyanobacterial blooms across the globe. It was therefore unexpected when, during an unusually warm and dry summer in southern Sweden in 2018, cyanobacteria did not dominate the phytoplankton community of the temperate Lake Vombsjön known for toxic cyanobacterial blooms.

At the onset of the pandemic, Brazil’s Federal government approved an emergency basic income to be transferred to a variety of groups that had not earlier received any of the established welfare programs. Its implementation was however riddled with challenges. With a large informal economy, many Brazilian citizens were missing from the Federal Government’s registry and, even if registered, many di

We study whether one reason behind female underrepresentation in leadership is that female leaders are less effective at coordinating followers’ actions. Two experiments using coordination games investigate whether female leaders are less successful than males in persuading followers to coordinate on efficient equilibria. In these settings, successful coordination hinges on higher-order beliefs ab

In most clinical situations involving adenovirus infection, subgenus (subgroup) identification of an adenovirus isolate is as informative as a finer identification by serotype. A PCR method which allows the identification of human adenovirus isolates as members of subgenera A, B:1, B:2, C, D, E, or F is described. It is based on a simple (nonnested) PCR using primers which bind to regions immediat

This paper develops a model of human capital accumulation with on-the-job learning subject to obsolescence risk. The model analytically characterizes trade-offs of reforming the level of income tax progressivity and matches well income inequality in the US. An enriched version is used to quantitatively investigate optimal tax progressivity in the US. In contrast to standard models with exogenous i

We develop a long-horizon asset pricing model in which equity investments may damage future production/consumption possibilities through their climate impact. We derive a four-fund separation result and determine the stocks' equilibrium returns. Stocks that have a sufficiently adverse impact on the climate may appear to have positive alphas relative to the CAPM. We further link our equilibrium ret

This paper presents tractable two parameter stochastic processes of the drift-diffusion class in order to model economic processes with a focus on income. Starting from the resulting closed-form, cross-sectional distributions, easy-to-interpret expressions for mobility and inequality (including the popular Gini-coefficient) are derived. The general processes are applied to discuss income mobility

This paper presents a closed-form expression for the concave consumption function in a model with liquidity constraints and spanned labor and capital income risk. Local Marginal Propensities to Consume (MPCs) and buffer-stock savings are analytically characterized allowing to identify its determinants. Solutions for common examples of the Hyperbolic Absolute Risk Aversion (HARA) class are presente