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Precision cancer medicine is a multidisciplinary team effort that requires involvement and commitment of many stakeholders including the society at large. Building on the success of significant advances in precision therapy for oncological patients over the last two decades, future developments will be significantly shaped by improvements in scalable molecular diagnostics in which increasingly com
Agricultural extension, or advisory services, have a key role to play in supporting farmers’ learning and adoption of new practices and technologies. This paper analyses gaps and needs which require addressing in order for extension systems to more effectively contribute to the upscaling of ecological intensification approaches in East African smallholder agriculture. Our starting point is the pus
Background: Fibrotic atrial cardiomyopathy plays an important role in determining the outcome of ablation in patients with atrial fibrillation (AF). Two main methods are being used for the evaluation of fibrosis: voltage-based high-density (HD) electroanatomical mapping (EAM) and late gadolinium enhancement MRI (LGE-MRI). The comparability between both methods in detecting fibrosis has not been sy
We consider Toeplitz determinants whose symbol has: (i) a one-cut regular potential, (ii) Fisher-Hartwig singularities and (iii) a smooth function in the background. The potential is associated with an equilibrium measure that is assumed to be supported on the whole unit circle. For constant potentials, the equilibrium measure is the uniform measure on the unit circle and our formulas reduce to we
Osteoporotic fracture is among the most common and costly of diseases. While reasonably heritable, its genetic determinants have remained elusive. Forearm fractures are the most common clinically recognized osteoporotic fractures with a relatively high heritability. To establish an atlas of the genetic determinants of forearm fractures, we performed genome-wide association analyses including 100,0
This chapter points to the fact that notwithstanding the global spread of English-medium instruction (EMI) and a growing body of research into EMI in different disciplines and higher education contexts, transnational, and comparative studies on EMI that draw on large-scale cross-institutional data are extremely scarce. Hence, the TAEC Corpus was created as part of the Erasmus+ project "Transnation
Context. Multi-planet systems are important sources of information regarding the evolution of planets. However, the long-period planets in these systems often escape detection. These objects in particular may retain more of their primordial characteristics compared to close-in counterparts because of their increased distance from the host star. HD 22946 is a bright (G = 8.13 mag) late F-type star
Cross-section measurements for a Z boson produced in association with high-transverse-momentum jets (p T ≥ 100 GeV) and decaying into a charged-lepton pair (e + e − , μ + μ −) are presented. The measurements are performed using proton–proton collisions at s = 13 TeV corresponding to an integrated luminosity of 139 fb −1 collected by the ATLAS experiment at the LHC. Measurements of angular correlat
This entry describes the basic aspects of grounded theory method (GTM) and covers four key points. First, the goal of GTM is to generate a theory. Often the coding procedures are leveraged independently by researchers for data analysis, not to generate a theory. Second, the use of GTM implies a noncommittal literature review, where the emerging theory determines the relevance of that literature re
Background: Opioid-related overdose deaths remain a common cause of death in many settings, and opioid maintenance treatment is evidence-based for the treatment of opioid use disorders. However, access to such treatment varies and is limited in many settings. Methods: The present study examines the longitudinal effects of a regional patient choice reform which substantially increased availability
BACKGROUND: Three-dimensional (3D) printing of highly porous orthopaedic implants aims to promote better osseointegration, thus preventing aseptic loosening. However, short-term radiostereometric analysis (RSA) after total knee arthroplasty (TKA) has shown higher initial migration of cementless 3D-printed tibial components compared with their cemented counterparts. Therefore, critical evaluation o
Data standards for quality registries should be evidence-based and follow guideline recommendations. To optimally monitor quality of care, not only patient-level variables, but also centre-level variables need to be included. Here we describe the development of variables to audit the structure and processes in cardiac rehabilitation for patients after myocardial infarction, and the resulting data
Background The 6-min walk test (6MWT) is widely used to assess exercise capacity across chronic health conditions, but is currently not useful to assess symptoms, as the scores do not account for the 6-min walk distance (6MWD). We aimed to 1) develop normative reference equations for breathlessness and leg discomfort intensity expressed as modified Borg (mBorg)/6MWD ratios; and 2) validate the equ
The application of technology to archaeology should be of great interest to many. In Chapter 1, entitled ‘Advancing Archaeological Research: the Contribution of Spatial Technologies’, Associate Professor Giacomo Landeschi of Lund University in Sweden, a specialist in archaeological computing, provides an overview of the main achievements gained through the use of new technologies in archaeology in
Nowadays, superparamagnetic iron oxide nanoparticles (SPIONs) have a dominant role in many subfields of biomedicine. Owing to their peculiar properties, they can be employed for magnetic separation, drug delivery, diagnostics, and hyperthermia treatments. However, these magnetic nanoparticles (NPs) suffer from low unit magnetization due to size constraints (up to 20-30 nm) to exhibit superparamagn
