Summary: The existing information supports the use of this material as described in this safety assessment. Isobutyl propionate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog isobutyl acetate (CAS # 110-19-0) show that isobutyl pro

For the generation of intense few-cycle laser pulses with stable carrier envelope phase (CEP), the approach of optical parametric chirped pulse amplification (OPCPA) is well established. In this contribution we present a compact and robust CEP-stable OPCPA system emitting pulses with energy above 10 μJ at 200 kHz repetition rate and pulse durations of 6.3 fs. Additionally, we present the results o

The activated B cell (ABC-like) subtype of diffuse large B cell lymphoma (DLBCL) is characterized by chronic activation of signaling initiated by immunoglobulin m (IgM). By analyzing the DNA copy number profiles of 1000 DLBCL tumors, we identified gains of 18q21.2 as the most frequent genetic alteration in ABC-like DLBCL. Using integrative analysis of matched gene expression profiling data, we fou

Background: Since the publication of the European League Against Rheumatism (EULAR) recommendations for the management of large vessel vasculitis (LVV) in 2009, several relevant randomised clinical trials and cohort analyses have been published, which have the potential to change clinical care and therefore supporting the need to update the original recommendations. Methods: Using EULAR standardis

This paper is the outcome of a community initiative to identify major unsolved scientific problems in hydrology motivated by a need for stronger harmonisation of research efforts. The procedure involved a public consultation through online media, followed by two workshops through which a large number of potential science questions were collated, prioritised, and synthesised. In spite of the divers

This article examines political parties’ approach to trade unions and the role of private and public party finance in contemporary democracies. We suggest that both unions’ direct donations and states’ party finance regimes may account for variation in the strength of parties’ organizational links to unions. We investigate this argument with a new data set covering parties historically aligned wit

The internet has opened up new possibilities for scholars to gather data and, in general, to stay updated on rapidly changing developments in the Chinese society. Social media has added yet another dimension as it enables researchers to follow events and public debates as they unfold as well as facilitate engagement and interactivity with informants and other contacts. This article is based on the

Low-frequency noise measurements were performed on high-performance InGaAs nanowire MOSFETs. 1/f noise measurements show number fluctuations, rather than mobility fluctuations, as the dominant noise source. The minimum equivalent input gate voltage noise reported here is 80 μm2μV2/Hz, among the lowest values for III-V FETs, and showing the feasibility of a high-quality, low trap density, high-k ga

INTRODUCTION: Numerous diagnostic criteria have tried to tackle the variability in clinical manifestations and problematic diagnosis of vascular cognitive impairment (VCI) but none have been universally accepted. These criteria have not been readily comparable, impacting on clinical diagnosis rates and in turn prevalence estimates, research, and treatment.METHODS: The Vascular Impairment of Cognit

Coprostanol was tested as ecological indicator to trace domestic and manure effluents and to investigate possible pollution sources in surface water. Pollution assessment was performed by analysing NO3 −, NO2 −, coprostanol (5β(H)-Cholestan-3β-ol), and cholestanol (5α(H)-Cholestan-3β-ol) in water samples from 42 sites along rivers in Shimabara and Unzen City, Japan. NO2-N concentration exceeded 0.

Background: Salinity is a significant environmental stress factor limiting crops productivity. Barley (Hordeum vulgare L.) has a natural tolerance to salinity stress, making it an interesting study object in stress biology research. In the present study, for the first time the effect of salinity stress on barley inflorescence developmental stages was investigated. Five spring barley genotypes irri

Operando ambient pressure photoelectron spectroscopy in realistic battery environments is a key development towards probing the functionality of the electrode/electrolyte interface in lithium-ion batteries that is not possible with conventional photoelectron spectroscopy. Here, we present the ambient pressure photoelectron spectroscopy characterization of a model electrolyte based on 1M bis(triflu

Organic farming can benefit plants and butterflies in terms of species richness and abundance, in particular in homogeneous landscapes. Nevertheless, whether organic farming can benefit functional diversity of these two organism groups is not well understood. Organic farming could benefit functional diversity by counteracting simplification and homogenisation of biotic communities caused by earlie