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While excessive production of reactive oxygen species (ROS) is a characteristic hallmark of numerous diseases, clinical approaches that ameliorate oxidative stress have been unsuccessful. Here, utilizing multi-omics, we demonstrate that in cardiomyocytes, mitochondrial isocitrate dehydrogenase (IDH2) constitutes a major antioxidative defense mechanism. Paradoxically reduced expression of IDH2 asso

The decay of excited states of the nucleus 135Sn, with three neutrons outside the doubly-magic 132Sn core, was studied in an experiment performed at the Radioactive Isotope Beam Factory at RIKEN. Several γ rays emitted from excited 135Sn ions were observed following one-neutron and one-neutron-one-proton removal from 136Sn and 137Sb beams, respectively, on a beryllium target at relativistic energi

There is a growing interest for the possibility of using peripheral blood cells (including platelets) as markers for mitochondrial function in less accessible tissues. Only a few studies have examined the correlation between respiration in blood and muscle tissue, with small sample sizes and conflicting results. This study investigated the correlation of mitochondrial respiration within and across

Large-scale landforms originated from jökulhlaups or glacial lake-outburst floods (GLOFs), and their small-scale components help in recognising the sedimentary environment of the flood. The GLOF fans that developed along the Pleistocene ice-sheet margin have not been investigated in detail, and north-eastern Poland, with its Megaflood Landform System and Bachanowo and Szeszupka fans, seems ideal f

In today's evolutionary development of software, continuous testing is needed to ensure that the software is still functioning after changes. Test automation helps partly managing the large number of executions needed, but there is also a limit for how much automated tests may be executed. Then systematic approaches for test selection are needed also for automated tests. This manuscript defines th

The bee louse (Braula coeca) is a honeybee inquiline and a long-standing taxonomic mystery. A new study unravels their genomic architecture and shows that these enigmatic flies have evolved from scale insect-exploiting drosophilid ancestors and share genetic similarities with their honeybee hosts.

Purpose: To understand the current practice in relation to the management of topical therapy for cutaneous chronic Graft versus Host Disease (ccGvHD) and access to extracorporeal photopheresis (ECP) within European allogeneic haematopoietic cell transplantation centres by a survey of nurses. Method: This was a multicentre cross-national study at eligible European Blood and Marrow Transplant centre

The widespread use of synthetic turf in sports has raised health concerns due to potential risks from nanoplastic inhalation or ingestion. Our research focused on detecting nanoplastics in drainage water from a synthetic football field and evaluating the toxicity of these materials after mechanical fragmentation. We collected and analysed drainage water samples for polymer content and subjected hi

Australia, characterized by extensive and heterogeneous terrestrial ecosystems, plays a critical role in the global carbon cycle and in efforts to mitigate climate change. Prior research has quantified vegetation productivity and carbon balance within the Australian context over preceding decades. Nonetheless, the responses of vegetation and carbon dynamics to the evolving phenomena of climate cha

Starch nanoparticles (SNPs) have been synthesized by nanoprecipitation method using starches from different botanical sources in native form and modified with octenyl succinic anhydride (OSA). SNPs were characterized in terms of size, morphology, charge, XRPD, FTIR and thermal properties. Spherical particles were obtained with sizes ranging from 54 to 108 nm and zeta potential values from −2 to −2

Background: Ice hockey is played by women and men but the arena they play in may differ substantially. Potential differences in general conditions to play the sport may be associated to perceived stress, which has shown to be related to athletic injury in other sports. Therefore, this study aimed to describe and compare general conditions for playing ice hockey, stress levels, and the association

The state of India acknowledges the rights of children as a guiding national policy principle, but also outsources much rights implementation to private actors such as NGOs. This article asks what happens to the concept of ‘rights’ when their implementation is dependent on the voluntary sector. Based on ethnographic material from one NGO-dependent child rights programme, and with the conceptual fr

Objectives Better understanding of societal factors associated with COVID-19 vaccination can have important implications for public health policy to increase uptake.Methods This study investigated sociodemographic determinants of COVID-19 vaccine uptake with ≥2 doses vs 0 doses, and ≥3 doses vs 2 doses, among adults (≥18 years) in a general population from Sweden followed from 27 December 2020 (n=

Build a linear accelerator to demonstrate spallation – the source of high-energy neutrons used by the new European Spallation Source being built in Sweden.In this activity, we build a model of a linear accelerator (linac) called a Gauss cannon. It uses magnetic attraction and momentum transfer to accelerate a series of steel balls, representing protons. At the end of the track, one ‘proton’ will cBuild a linear accelerator to demonstrate spallation – the source of high-energy neutrons used by the new European Spallation Source being built in Sweden.In this activity, we build a model of a linear accelerator (linac) called a Gauss cannon. It uses magnetic attraction and momentum transfer to accelerate a series of steel balls, representing protons. At the end of the track, one ‘proton’ will c

This study examines the integration of climate change and biodiversity into business strategies and governance structures of listed firms on the Swedish stock exchange NasdaqOMX Large Cap. The results show clear disparities in the level of integration and the factors driving the integration process. All, but a few small firms, have integrated climate change into business strategies, and are ahead This study examines the integration of climate change and biodiversity into business strategies and governance structures of listed firms on the Swedish stock exchange NasdaqOMX Large Cap. The results show clear disparities in the level of integration and the factors driving the integration process. All, but a few small firms, have integrated climate change into business strategies, and are ahead