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ST-Segment deviation analysis of the admission 12-lead electrocardiogram as an aid to early diagnosis of acute myocardial infarction with a cardiac magnetic resonance imaging gold standard

Objectives The purpose of this study was to validate existing 12-lead electrocardiographic (ECG) ST-segment elevation myocardial infarction (STEMI) criteria in the diagnosis of acute myocardial infarction (AMI) and the application of similar ST-segment depression (STEM I-equivalent) criteria with contrast-enhanced cardiac magnetic resonance imaging (ceMRI) as the diagnostic gold standard. Backgrou

Activated sludge wastewater treatment plant modelling and simulation: state of the art

This review paper focuses on modelling of wastewater treatment plants (WWTP). White-box modelling is widely applied in this field, with learning, design and process optimisation as the main applications. The introduction of the ASM model family by the IWA task group was of great importance, providing researchers and practitioners with a standardised set of basis models. This paper introduces the n

Proteolysis and its regulation at the surface of Streptococcus pyogenes.

Pathogenic bacteria often produce proteinases that are believed to be involved in virulence. Moreover, several host defence systems depend on proteolysis, demonstrating that proteolysis and its regulation play an important role during bacterial infections. Here, we discuss how proteolytical events are regulated at the surface of Streptococcus pyogenes during infection with this important human pat

Conflicting demands on wetland ecosystem services: nutrient retention, biodiversity or both?

1. Wetland ecosystems may, besides having considerable economical value, increase landscape biodiversity and function as traps for nutrients from land to freshwater- and marine systems. As a result of these features, wetlands are nowadays often protected and restored, and many countries have even initiated wetland construction programmes. 2. In the present study, we aim at increasing the knowledge

Clinical and histopathological features of malignant melanoma in germline CDKN2A mutation families

Primary cutaneous malignant melanomas (CMMs) from 26 individuals belonging to nine families with an identified CDKN2A mutation were clinically and histopathologically compared with 78 matched CMM controls and with a population-based series of CMMs (n=667). All tumours were histopathologically re-examined. CDKN2A-associated cases were significantly less invasive compared with the matched controls,

Monitoring of glucose and glutamate using enzyme microstructures and scanning electrochemical microscopy.

Glucose oxidase and glutamate oxidase lines, with typical width of 100 microm, were patterned on gold surfaces using a micro-dispensing system, by shooting 100 pl droplets of the corresponding enzyme solutions. The probe of a scanning electrochemical microscope (SECM) was then carefully positioned in the close proximity of the enzyme microstructure and poised to +600 mV vs. Ag/AgCl, KCl 0.1 M. The

Enteral crude red kidney bean (Phaseolus vulgaris) lectin--phytohemagglutinin--induces maturational changes in the enterocyte membrane proteins of suckling rats.

This study aimed to investigate the effect of enterally administered crude red kidney bean (Phaseolus vulgaris) lectin, PHA, on the expression of brush-border membrane vesicle (BBMV) proteins, in particular Na+/H+ exchangers (NHEs), in the small intestine of suckling rats. Gavage of PHA to 14-day-old rats for 3 days resulted in altered protein/glycoprotein patterns as analyzed by SDS-PAGE. Immunob

Improved operational stability of chloroperoxidase through use of antioxidants.

Chloroperoxidase (CPO) from Caldariomyces fumago is a potentially very useful enzyme due to its ability to catalyze a large variety of stereoselective oxidation reactions, but poor operational stability is a main limitation for commercial use. In the present study, the possibility of increasing the operational stability by use of antioxidants was investigated using the oxidation of indole as model

Long-term land-use changes and extinction of specialised butterflies

1. Land-use change in 450 ha in southern Sweden between 1814 and 2004 was recorded. Butterflies and burnet moths were surveyed in 1904–1913 and 2001–2005. 2. We explore if local extinctions were related to land-use changes and species attributes. 3. Land use changed drastically over the 190-year period, and the largest relative change occurred for hay meadows with late harvest, which decreased fro

Sertoli-Leydig cell tumour in a postmenopausal woman showing all facets of the insulin resistance syndrome (IRS)

Sertoli-Leydig cell tumours are rare sex stromal tumours with an incidence of < 0.5% of all ovarian tumours. Most frequently this tumour occurs in young women with a history of amenorrhoea, hirsutism and lowered pitch. Here, we report on a woman with IRS, postmenopausal virilization and increased testosterone levels due to a Sertoli-Leydig cell tumour. This is the first case to suggest an associat