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Nine senior researchers from five different faculties at Lund University have been granted three million SEK for a novel transdisciplinary initiative to improve the early diagnosis of Alzheimer’s disease. Four of them are research leaders from the strategic research area MultiPark at the Medical Faculty. The collaboration also involves Region Skåne, Lund Municipality, and several important partner

https://www.multipark.lu.se/article/three-million-new-thematic-collaboration-initiative-about-early-diagnosis-and-prognostics-alzheimers - 2025-10-25

Researchers at Lund University in Sweden have developed an algorithm that combines data from a simple blood test and brief memory tests, to predict with great accuracy who will develop Alzheimer's disease in the future. The findings are published in Nature Medicine. Approximately 20-30% of patients with Alzheimer's disease are wrongly diagnosed within specialist healthcare, and diagnostic work-up

https://www.multipark.lu.se/article/simple-diagnostic-tool-predicts-individual-risk-alzheimers - 2025-10-25

During her Ph.D. studies, Yiyi Yang has been investigating the role of microglia in the pathological development of Alzheimer’s disease. On the 3rd of June, it is time to defend her work supervised by Prof. Tomas Deierborg. Now, Yiyi tells us about her research in the Experimental Neuroinflammation Laboratory as being a part of MultiPark. Can you tell us about your Ph.D. research? The focus of our

https://www.multipark.lu.se/article/phd-defence-interview-yiyi-yang - 2025-10-25

Around 20 000 Swedes are currently suffering from Parkinson’s disease, yet there are still only treatments to alleviate symptoms. Through a new biobank, researchers gain access to the genetic profiles of 1000 Parkinson’s patients together with comprehensive information about their lifestyles and medical histories. “I am convinced that many researchers will use the biobank over the next few years,

https://www.multipark.lu.se/article/new-biobank-provides-insights-parkinsons-disease - 2025-10-25

On the first of January, Professor Angela Cenci Nilsson took on as the new coordinator for MultiPark. Now she tells us about her visions for our network and about being a senior researcher in the environment. About the role as the new coordinator   I will do my best to foster collaborative projects with high scientific and/or translational potential.   What does being appointed to the new coordina

https://www.multipark.lu.se/article/interview-angela-cenci-nilsson-about-being-new-coordinator-multipark - 2025-10-25

T-cells, antibodies, and antigens. During the past year, we have learned a lot about our immune system through media. Most people agree that the immune system is crucial for our survival. But how does the immune system affect Parkinson’s disease; is it necessary to keep our brains healthy, or does it contribute to disease progression? The answer to that question is unfortunately not straightforwar

https://www.multipark.lu.se/article/does-our-immune-response-affect-risk-developing-parkinsons-disease - 2025-10-25

An experimental study from Lund University in Sweden has revealed that the Alzheimer’s protein amyloid-beta accumulates inside nerve cells, and that the misfolded protein may then spread from cell to cell via nerve fibres. This happens at an earlier stage than the formation of amyloid-beta plaques in the brain, something that is associated with the progression of Alzheimer’s disease. The study in

https://www.multipark.lu.se/article/does-alzheimers-disease-start-inside-nerve-cells - 2025-10-25

A large collaborative project focused on understanding and treating dysfunctions of cortico-basal ganglia circuits in Parkinson´s disease (PD) has been awarded 35 million DKK from the Lundbeck Foundation. Angela Cenci Nilsson, coordinator of MultiPark, leads one of the three included research teams. Her group, the Basal ganglia pathophysiology, will conduct studies in animal models providing a bas

https://www.multipark.lu.se/article/new-transnational-collaboration-target-circuit-dysfunctions-parkinsons-disease - 2025-10-25

A combination of two imaging methods can be used to achieve structural and chemical information within a single neuron. Researchers from MultiPark at Lund University recently developed this approach. Their study reveals that amyloid aggregates, implicated in Alzheimer’s disease, may cause clustering of iron in primary neurons. Alzheimer's disease is a major cause of dementia. Understanding where a

https://www.multipark.lu.se/article/novel-imaging-approach-open-doors-understanding-key-pathological-processes-inside-neurons - 2025-10-25

Amyloid-beta accumulation may start inside neurons. A novel imaging approach to study structural changes before amyloid plaques are formed. Four distinct subtypes of Alzheimer's disease. A simple diagnostic tool predicting the risk of developing the disease. And a collaboration with Region Skåne, Lund Municipality, and the pharma industry to facilitate earlier diagnosis and more accurate prognosti

https://www.multipark.lu.se/article/alzheimers-awareness-month-five-optimistic-research-news-multipark - 2025-10-25

A machine allowing researchers to rely on objective, automatized readouts instead of subjective manual counting under the microscope. Incredible pictures. And the possibility to follow live cellular events. The Operetta is the answer to these demands. The interest in using the new MultiPark infrastructure is big. In March, MultiPark received the new Operetta CLS instrument, upgrading the former Ce

https://www.multipark.lu.se/article/seven-tones-operetta-multiparks-new-high-content-analysis-platform - 2025-10-25

Our DNA is very similar to that of the chimpanzee, which in evolutionary terms is our closest living relative. Stem cell researchers at Lund University in Sweden have now found a previously overlooked part of our DNA, so-called non-coded DNA, that appears to contribute to a difference which, despite all our similarities, may explain why our brains work differently. The study is published in the jo

https://www.multipark.lu.se/article/what-makes-us-human-answer-may-be-found-overlooked-dna - 2025-10-25

During her thesis project, Nadja Gustavsson has characterized structural changes inside neurons of a new mouse model for mixed neurogenerative disorders. On the 21st of October, she is defending her thesis supervised by Oxana Klementieva. In this interview, Nadja shares her ups and downs during her time as a Ph.D. student in MultiPark. Tell us about your Ph.D. research! Our lab utilizes a novel ap

https://www.multipark.lu.se/article/phd-defence-interview-nadja-gustavsson - 2025-10-25

Meningitis is a very serious brain infection with limited treatment options. In a new study performed in rats, researchers from the University of Copenhagen present an alternative treatment based on immune cells that helps rinse away toxins that accumulate during the infection. Fever, headache, confusion, seizures, amputations, or death. Meningitis is a very serious brain infection that can affect

https://www.multipark.lu.se/article/meningitis-researchers-find-possible-treatment-strategy-without-antibiotics - 2025-10-25

Collaboration, networking, career development, and wellbeing. Those are four examples of needs that the newly formed young MultiParkers working group will address. After organizing their first event, they are eager to start preparing for more events. During the pandemic, there has been an upbuild of need for social gathering and exchange of ideas and experiences. Especially young researchers who r

https://www.multipark.lu.se/article/young-multiparkers-working-group-takes-shape - 2025-10-25

Receiving grants from the Swedish Research Council is viewed as a quality mark and one of the critical steps for young scientists to establish an independent research group. Last week, nine of MultiPark’s research leaders were awarded 31.6 million SEK for their projects. This year’s support from the Swedish Research Council encouraged MultiPark’s ambition to be a multidisciplinary research area. P

https://www.multipark.lu.se/article/nine-multipark-scientists-granted-support-swedish-research-council - 2025-10-25

During his research education, Jonathan Timpka wanted to elucidate what is affecting the ability to work for patients diagnosed with Parkinson’s disease. Defending his Ph.D. thesis on November 19th, Jonathan tells about his wide range of projects within the Restorative Parkinson Unit led by Per Odin. Tell us about your Ph.D. research! My research engagement has been quite diverse, ranging from reg

https://www.multipark.lu.se/article/phd-defence-interview-jonathan-timpka - 2025-10-25

Gene expression inside Parkinson’s disease patient’s brain cells seems to trigger structural changes of the Parkinson-linked protein alpha-synuclein. This was discovered when MultiPark researchers converted skin cells from Parkinson patients into midbrain cells in the dish. The study was published in Acta Neuropathologica Communications. Parkinson’s disease (PD) is a neurodegenerative disorder lin

https://www.multipark.lu.se/article/environment-inside-brain-cells-holds-clues-protein-aggregation - 2025-10-25

Emil Ygland Rödström is defending his thesis on the 20th of November. His research is about clinical, genetical, and biochemical biomarkers for the prognosis of Parkinson’s disease patients. Here, he tells us more about the discoveries and his time as a Ph.D. student in the Clinical Neurogenetics group at MultiPark. What is your research about? My thesis work consists of two different parts. In th

https://www.multipark.lu.se/article/phd-defence-interview-emil-ygland - 2025-10-25

Presently many of Sweden’s 20,000 Parkinson’s patients are not receiving the treatment they need, and many of the most seriously ill receive incorrect or inappropriate therapy. With the new Manage PD tool and the PD Pal study, Per Odin, professor at Lund University and senior attending physician at Skåne University Hospital in Lund, hopes to be able to improve the care of Parkinson’s patients. Eve

https://www.multipark.lu.se/article/faster-and-better-treatment-parkinsons-disease-manage-pd-tool - 2025-10-25