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Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum.

Importance: One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid aggregation, which can be detected by biomarkers in cerebrospinal fluid (CSF) and on positron emission tomography (PET) scans. Prevalence estimates of amyloid pathology are important for health care planning and clinical trial design.Objective: To estimate the prevalence of amyloid abnormality in p

Λc+ production in pp and in p -Pb collisions at sNN =5.02 TeV

The production cross section of prompt Λc+ charm baryons was measured with the ALICE detector at the LHC at midrapidity in proton-proton (pp) and proton-lead (p-Pb) collisions at a center-of-mass energy per nucleon pair of sNN=5.02TeV. The Λc+ and Λ¯c- baryons were reconstructed in the hadronic decay channels Λc+→pK-π+ and Λc+→pKS0 and respective charge conjugates. The measured differential cross

Double-parton scattering mechanism for associated c c ¯ l+l- production in AA ultraperipheral collisions as a probe for the photon density inside the nucleus

We discuss the associated cc¯ and l+l- pairs production in ultraperipheral heavy-ion collisions at high energies. Such a channel provides a novel probe for double-parton scattering (DPS) at small x enabling one to probe the photon density inside the nucleus. We have derived an analog of the standard central pp pocket formula and studied the kinematical dependence of the effective cross section. Ta

Knowledge discoveryweb service for spatial data infrastructures

The size, volume, variety, and velocity of geospatial data collected by geo-sensors, people, and organizations are increasing rapidly. Spatial Data Infrastructures (SDIs) are ongoing to facilitate the sharing of stored data in a distributed and homogeneous environment. Extracting high-level information and knowledge from such datasets to support decision making undoubtedly requires a relatively so

Effects of dynamical screening on the BCS-BEC crossover in double bilayer graphene : Density functional theory for exciton bilayers

We derive a gap equation for bilayer excitonic systems based on density functional theory and benchmark our results against quantum Monte Carlo simulations and recent experiments on double bilayer graphene. The gap equation has a mean-field form but includes a consistent treatment of dynamical screening. We show that the gap survives at much higher densities than previously thought from mean-field

Modeling protein target search in human chromosomes

Several processes in the cell, such as gene regulation, start when key proteins recognize and bind to short DNA sequences. However, as these sequences can be hundreds of million times shorter than the genome, they are hard to find by simple diffusion: diffusion-limited association rates may underestimate in vitro measurements up to several orders of magnitude. Moreover, the rates increase if the D

Artificial Intelligence and the City : urbanistic Perspectives on AI

This book explores in theory and practice how artificial intelligence (AI) intersects with and alters the city. Drawing upon a range of urban disciplines and case studies, the chapters reveal the multitude of repercussions that AI is having on urban society, urban infrastructure, urban governance, urban planning and urban sustainability.Contributors also examine how the city, far from being a pass

Models for Non-Modelers : Understanding the Use of Models for Social Scientists and Others

Models for Non-Modelers focuses not on how to design models but on how to understand and critically appraise them. Data and statistical models are widely used in disciplines such as epidemiology, climate science and systems design, but it can be difficult for those without the necessary training to understand and implement them. This book is for non-modelers, especially social scientists. Through

Provsamlingen Swecrit och AI ger ny kunskap vid intensivvård

The unique Swecrit Biobank and its associated clinical registries for sepsis, ARDS, cardiac arrest, trauma, and COVID-19 include more than 150,000 blood samples and descriptions of critically ill patients. These assets provide a unique opportunity to research and improve the care of the most seriously ill patients through biomarker analyses, proteomic studies, and genetic and epigenetic studies us

A TDLAS-based photofragmentation method for spatially resolved measurement of KOH and KCl as well as its application in biomass combustion processes

The release of gas-phase potassium species, mainly KOH, KCl, and K atoms, from burning biomass fuels can introduce severe problems to boilers, such as fouling, slagging, and corrosion. In the present work, an optical technique combining laser-induced photofragmentation and tunable diode laser absorption spectroscopy is developed for simultaneously measuring the concentration of KOH, KCl and K atom

Combustion of micron-sized Al-Mg alloy wires in hot H2O/O2/N2 flows

The use of aluminum-magnesium (Al-Mg) alloy particle as energetic additive in solid propellants was previously shown to have many advantages over pure Al particle, such as relatively low ignition temperature, high reaction rate and low particle agglomeration rate. In this paper, the combustion of Al-Mg alloy in hot H2O/O2/N2 flows was experimentally studied using wires with a diameter of 200 µm. T

Gestational hypertension, preeclampsia, and gestational diabetes mellitus after high exposure to perfluoroalkyl substances from drinking water in Ronneby, Sweden

Background: Leakage of fire-fighting foam from an airfield caused contamination of the drinking water supplied to a third of the population in Ronneby, resulting in very high serum levels of predominantly perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonate (PFHxS). The results of studies investigating the association between exposure to perfluorinated alkyl substances (PFAS) and pregnan

Laser Diagnostics in Reacting Flows

Burst-mode laser systems have widely been employed in diagnostics for both reactive and non-reactive flows. Unlike the continuous pulse lasers, burst-mode lasers generate pulses in bursts lasting up to 100 ms, capable to deliver high energies up to Joules per pulse. This high energy fluency is optimal for effective wavelength conversion and tuning, enabling simultaneous measurements of various spe