BACKGROUND: Autistic people are more likely to report problematic alcohol and other substance use when compared to the general population. Evidence suggests that up to one in three autistic adults may have an alcohol or other substance use disorder (AUD/SUD), although the evidence base for behavioural addictions is less clear. Autistic people may use substances or engage in potentially addictive b

BACKGROUND: Restrictive measures (RM) are prevalent in services for people with intellectual disabilities. This study investigates managerial awareness of RM and the nature of organisational supports required to reduce their use.METHOD: A survey asked front-line managers and staff what (RM) were used, their purpose, impact and importance (10-item Likert scales) and what organisational changes were

BACKGROUND: The Pediatric Outcomes Data Collection Instrument (PODCI) is a validated quality-of-life questionnaire with 6 domains designed to provide a standardized method of measuring outcomes in pediatric musculoskeletal conditions. To our knowledge there are no reports on its use in children with multiple hereditary exostosis (MHE).QUESTIONS/PURPOSES: Most published studies on MHE patients have

Structural brain MRI has proven invaluable in understanding movement disorder pathophysiology. However, most work has focused on grey/white matter volumetric (macrostructural) and white matter microstructural effects, limiting understanding of frequently implicated grey matter microstructural differences. Using ultra-strong spherical tensor encoding diffusion-weighted MRI, a persistent MRI signal

A significant problem in diffusion MRI (dMRI) is the lack of understanding regarding which microstructural features account for the variability in the diffusion tensor imaging (DTI) parameters observed in meningioma tumors. A common assumption is that mean diffusivity (MD) and fractional anisotropy (FA) from DTI are inversely proportional to cell density and proportional to tissue anisotropy, resp

The choroid plexus (ChP) is part of the blood-cerebrospinal fluid barrier, regulating brain homeostasis and the brain's response to peripheral events. Its upregulation and enlargement are considered essential in psychosis. However, the timing of the ChP enlargement has not been established. This study introduces a novel magnetic resonance imaging-based segmentation method to examine ChP volumes in

Magnetic resonance imaging (MRI) is the primary method for noninvasive investigations of the human brain in health, disease, and development but yields data that are difficult to interpret whenever the millimeter-scale voxels contain multiple microscopic tissue environments with different chemical and structural properties. We propose a novel MRI framework to quantify the microscopic heterogeneity

American photographer Jerry N. Uelsmann (1934–2022) was a seminal figure in photo history. Uelsmann catalyzed the transfer from modernist to post-modern photography with his at the time controversial photo montages and double exposures. Decades before the birth of digital image editing programs like Photoshop, Uelsmann created photo montages by combining several negatives in the darkroom. He start

Under covid-19-pandemin blev många anställda rekommenderade eller tvingade att arbeta på distans (Fackförbundet ST, 2020; Wang m.fl., 2021). Sammantaget arbetade 30–40 procent av arbetstagarna hela eller delar av sin arbetstid på distans under pandemin (Myndigheten för arbetsmiljökunskap, 2021). Den fysiska arbetsplatsen var inte längre en självklarhet; från en dag till en annan blev i stället dis

Dataspelsbranschen beskrivs som både en kulturell näring och som en del av tech-industrin. De olika beskrivningarna ger skilda associationer och illustrerar branschens många sidor. Det är också illustrativt för arbetet som spelutvecklare, vilket ofta beskrivs som en skärningspunkt mellan såväl konstnärligt arbete och teknik, som mellan kultur och kommers. I ett pågående forskningsprojekt om spelut

Background/AimOpioid overdose deaths have increased in Sweden and other developed countries in recent decades, despite increased treatment efforts and harm-reduction interventions. Further knowledge in this field is needed if this trend is to be reversed. Previous research suggests that mental health and patterns of prescription of opioids and other prescription drugs are associated with increased

Non-negative matrix factorization (NMF) is a relatively new approach to analyze gene expression data that models data by additive combinations of non-negative basis vectors (metagenes). The non-negativity constraint makes sense biologically as genes may either be expressed or not, but never show negative expression. We applied NMF to five different microarray data sets. We estimated the appropriat