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Dipeptidyl peptidase 4 (DPP4) has been proposed as a marker for activated fibroblasts in fibrotic disease. We aimed to investigate whether a profibrotic DPP4 phenotype is present in lung tissue from patients with idiopathic pulmonary fibrosis (IPF). The presence of DPP4 + fibroblasts in normal and IPF lung tissue was investigated using flow cytometry and immunohistology. In addition, the involveme

SLA research is characterised by a striking homogeneity in the linguistic, social and geographical data we draw on. Such empirical homogeneity is a potential threat to the validity and scope of our claims and theories. This paper focuses on a particular gap in our knowledge, namely the SLA of sign languages. It outlines an argument for why the SLA of sign matters to general SLA research in terms o

Increasing air temperatures reduce the duration of ice cover on lakes and rivers, threatening to alter their water quality, ecology, biodiversity, and physical, economical and recreational function. Using a unique in situ record of freeze and break-up dates, including records dating back to the beginning of the 18th century, we analyze changes in ice duration (i.e., first freeze to last break-up),

Neutron tomography has emerged as a promising imaging technique for specific applications in bone research. Neutrons have a strong interaction with hydrogen, which is abundant in biological tissues, and they can penetrate through dense materials such as metallic implants. However, in addition to long imaging times, two factors have led to challenges in running in situ mechanical characterization e

Background: A prosthetic joint infection (PJI) is a devastating complication following total joint arthroplasties with poor prognosis. Identifying an accurate and prompt diagnostic method is particularly important for PJI. Recently, the diagnostic value of metagenomic next-generation sequencing (mNGS) in detecting PJI has attracted much attention, while the evidence of its accuracy is quite limite

Ground-based, high-resolution spectrographs are providing us with an unprecedented view of the dynamics and chemistry of the atmospheres of planets outside the Solar System. While there are a large number of stable and precise high-resolution spectrographs on modest-size telescopes, it is the spectrographs at observatories with apertures larger than 3.5 m that dominate the atmospheric follow-up of

This study focuses on one of the critical design parameters of lean premixed (LPM) combustors-the air split ratio (ASR) between the pilot and main stages. The effect of the air split ratio on thermoacoustic instability is experimentally studied based on a centrally staged model combustor. It is found that the thermoacoustic instability is suppressed with the ASR higher than 20%. The acoustic modes

Despite lizards using a wide range of colour signals, the limited variation in photoreceptor spectral sensitivities across lizards suggests only weak selection for species-specific, spectral tuning of photoreceptors. Some species, however, have enhanced short-wavelength sensitivity, which probably helps with the detection of signals rich in ultraviolet and short wavelengths. In this study, we exam

INTRODUCTION: The development of inhibitory antibodies (inhibitors) in persons with hemophilia B (PwHB) causes significant morbidity. Data on the impact of the F9 variant and immune tolerance induction (ITI) outcome are limited. The aim of this study was to investigate the presence of neutralizing and non-neutralizing antibodies (NNA) in severe hemophilia B (HB) and to evaluate ITI outcome and com

Accurate identification of independent predictors of stillbirth is needed to define preventive strategies. We aim to examine the independent contribution of maternal race in the risk of stillbirth after adjusting for maternal characteristics and medical history. There are two components to the study: first, prospective screening in 168,966 women with singleton pregnancies coordinated by the Fetal

The prediction of species geographic redistribution under climate change (i.e. range shifts) has been addressed by both experimental and modelling approaches and can be used to inform efficient policy measures on the functioning and services of future ecosystems. Dynamic global vegetation models (DGVMs) are considered state-of-the art tools to understand and quantify the spatio-temporal dynamics o

This paper explores the concept and the levels of genericity of different instruments, or beamlines, at a synchrotron radiation facility. We use conceptual tools from the sociology of science, bibliometrics and data from the European Synchrotron Radiation Facility (ESRF) publication database, enriched by data from Web of Science. The sample size is of 11,218 observations for the period 1996 to 201