Deregulated expression of the MYC oncogene is a frequent event during tumorigenesis and generally correlates with aggressive disease and poor prognosis. While MYC is a potent inducer of apoptosis, it often suppresses cellular senescence, which together with apoptosis is an important barrier against tumor development. For this latter function, MYC is dependent on cyclin-dependent kinase 2 (CDK2). H

Aims: To describe and compare perceptions of collaboration between care providers on the part of three groups of Registered Nurses working in municipal care and having particular responsibility concerning the care of frail older people with intellectual disability (ID); and, furthermore, to investigate the presence of and compliance with guidelines for the coordination of care.Design: National surAims: To describe and compare perceptions of collaboration between care providers on the part of three groups of Registered Nurses working in municipal care and having particular responsibility concerning the care of frail older people with intellectual disability (ID); and, furthermore, to investigate the presence of and compliance with guidelines for the coordination of care. Design: National su

OBJECTIVE: Assess the quality of healthcare across African countries based on health providers' clinical knowledge, their clinic attendance and drug availability, with a focus on seven conditions accounting for a large share of child and maternal mortality in sub-Saharan Africa: malaria, tuberculosis, diarrhoea, pneumonia, diabetes, neonatal asphyxia and postpartum haemorrhage.METHODS: With nation

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After decades of theoretical neglect of material properties and relations, a much welcome material turn within social science energy research has recently raised discussions of materiality to the centre of current debates. So far, the efforts to rematerialize energy has to a large extent drawn on new materialist thinking. Against the substantivalist conception of energy resources as self-standing

The clear cell, chromophobe and papillary carcinoma as well as oncocytoma are the most common renal tumours. While cases of hybrid renal tumours are well known, the true collision renal tumour of oncocytoma and Papillary Renal Cell Carcinoma (PRCC) is still rare. Herein, we present a case of a true collision renal tumour of an oncocytoma and a PRCC as well as a review of the literature.

This work aims at studying photoionization dynamics from atoms and surfaces at attose time scales. The work was based on development and applications of a high repetition rate High-order Harmonic Generation (HHG) light source that utilizes Optical Parametric Amplification (OPA) laser technology. The laser system delivers few-cycle pulses in the near infrared (IR) at a repetition rate of 200 kHz. TThis work aims at studying photoionization dynamics from atoms and surfaces at attose time scales. The work was based on development and applications of a high repetition rate High-order Harmonic Generation (HHG) light source that utilizes Optical Parametric Amplification (OPA) laser technology. The laser system delivers few-cycle pulses in the near infrared (IR) at a repetition rate of 200 kHz. T

Higher music education (HME) in Europe is multifaceted due to the great variety of legal frameworks, conservatory histories and practices. However, following the Bologna declaration in 1999, traditional conservatories are gradually transforming into research-based institutions, which means combining advanced performer training with artistic research. After a background on academisation in the highHigher music education (HME) in Europe is multifaceted due to the great variety of legal frameworks, conservatory histories and practices. However, following the Bologna declaration in 1999, traditional conservatories are gradually transforming into research-based institutions, which means combining advanced performer training with artistic research. After a background on academisation in the high

Background: Breast cancer-related lymphedema (BCRL) is associated with impaired function and poorer quality of life. BCRL is also considered time-consuming and costly to treat. While compression treatment is considered the most efficient and effective form of treatment for early BCRL, its impact on the lymphatic system highlights its potential in the prevention of lymphedema. Objectives: To identi

Background: Geographic variations in management and outcomes of individuals supported by continuous-flow left ventricular assist devices (CF-LVAD) between the United States (US) and Europe (EU) is largely unknown. Methods: We created a retrospective, multinational registry of 524 patients who received a CF-LVAD (either HVAD or Heartmate II) between January 2008 and April 2017. Follow up spanned fr

Background & Aims: Few patients with primary sclerosing cholangitis (PSC) and inflammatory bowel diseases (IBDs) are exposed to tumor necrosis factor (TNF) antagonists because of the often mild symptoms of IBD. We assessed the effects of anti-TNF agents on liver function in patients with PSC and IBD, and their efficacy in treatment of IBD. Methods: We performed a retrospective analysis of 141

Background: The therapeutic alliance may be a moderating factor of outcome in the Attempted Suicide Short Intervention Program (ASSIP). Aims: This study investigates the two components of the therapeutic alliance, patients' satisfaction with the therapeutic relationship and therapeutic outcome and their associations with suicidal ideation over time. Method: A total of 120 patients (55% female; mea

This article summarizes and integrates research on the relation between altered consciousness (including states and traits, as well as procedures and practices to induce them) and enhanced functioning. The latter include improved psychophysiological control as well as enhanced performance in controlled parapsychological experiments. Multiple studies on meditation, hypnosis, sensory homogenization,

This paper presents the results from the characterization of pneumatic touch sensors (sensing bulbs) designed to be integrated into myoelectric prostheses and body-powered prostheses. The sensing bulbs, made of silicone, were characterized individually (single sensing bulb) and as a set of five sensors integrated into a silicone glove. We looked into the sensing bulb response when applying pressur

We propose reframing one of the key questions in the field of language evolution as what was the original human-specific communicative system? With the help of cognitive semiotics, first we clarify the difference between signals, which characterize animal communication, and signs, which do not replace but complement signals in human communication. We claim that the evolution of bodily mimesis allo