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Downregulation of growth hormone in postural orthostatic tachycardia syndrome: insights from the SYSTEMA cohort

Background Postural orthostatic tachycardia syndrome (POTS) is a variant of cardiovascular autonomic disorder occurring predominantly in young women. POTS is characterized by an excessive heart rate increase when assuming upright posture accompanied by symptoms of orthostatic intolerance. The pathophysiology of POTS has not been fully established and is believed to be multifactorial. Purpose We a

Detection of inflammatory biomarkers associated with postural orthostatic tachycardia syndrome: insights from the SYSTEMA cohort

Background: Postural Orthostatic Tachycardia Syndrome (POTS) is a cardiovascular dysautonomic condition affecting predominantly young women. POTS is defined as the presence of chronic symptoms of orthostatic intolerance associated with an increased heart rate ≥30 bpm, or heart rate exceeding 120 bpm, within 10 minutes of standing or head-up tilt in the absence of orthostatic hypotension. The etio

The social network of patients with schizoaffective disorder as compared to patients with diabetes and to healthy individuals

The social network was evaluated by means of the self-rating scale 'Interview Schedule for Social Interaction' (ISSI) and semi-structured interviews in married patients with a DSM-III diagnosis of schizoaffective disorder (N = 17, partners, N = 16), married patients with diabetes (N = 10, partners, N = 10) and in married healthy individuals (N = 8, partners, N = 8). The two latter groups were comp

Novel three-dimensional chitosan-carbon nanotube–PVA nanocomposite hydrogel for removal of Cr6+ from wastewater

A novel hybrid nanocomposite adsorbent was prepared by encapsulation of multi-walled carbon nano-tubes within polyvinyl alcohol/chitosan hydrogel (Cs/MWCNT/PVA) and cross-linked with glu-taraldehyde. The chemical reactions between the components affected the position and intensities of the infrared bands. This nanocomposite has excellent Cr6+ ions adsorption efficiency. The optimal conditions of t

Formation of moon systems around giant planets : Capture and ablation of planetesimals as foundation for a pebble accretion scenario

The four major satellites of Jupiter, known as the Galilean moons, and Saturn's most massive satellite, Titan, are believed to have formed in a predominantly gaseous circum-planetary disk during the last stages of formation of their parent planet. Pebbles from the protoplanetary disk are blocked from flowing into the circumplanetary disk by the positive pressure gradient at the outer edge of the p

Deliberate self‐poisoning : treatment follow‐up of repeaters and nonrepeaters

Since 1986 psychiatrists and social workers of the Lund Suicide Research Center have investigated subjects admitted to the medical intensive care unit after a suicide attempt. Fifty‐nine of 79 deliberate self‐poisoners were interviewed 12 months after a suicide attempt. Twenty‐one had previously been interviewed 6 months after the index suicide attempt. We obtained minor information on 8 subjects.

Smoking and endothelial dysfunction

Cigarette smoking is one of the most important health concerns worldwide. Even though the rate of smoking is declining in developed countries, it is still experiencing growth in developing regions. Many studies have examined the relationship between smoking, as an established risk factor, and cardiovascular diseases. We provide an updated review of the underlying mechanisms of smokinginduced cardi

Deliberate self‐poisoning : repeaters and nonrepeaters admitted to an intensive care unit

Seventy‐nine patients admitted to the Lund Intensive Care Unit after deliberate self‐poisoning were investigated by a psychiatrist and a social worker by means of a semi structured interview. Suicide risk evaluation included statistical risk factors according to the SAD PERSONS Scale, severity of suicidal intent according to the Suicidal Intent Scale, and interviewer reaction according to Motto. T

3D LIF/Mie planar droplet s izing in IC engine sprays using single-droplet calibration data

This paper reports on the quantitative 2D and 3D droplet sizing based on the LIF/Mie ratio in ethanol DISI (Direct Injection Spark Ignition) sprays, where the required calibration is performed using quantitative micro and macro LIF/Mie ratio imaging of individual microdroplets. The droplets are generated from a monodisperse droplet generator in a diameter range from 16 µm to 60 µm. First, the liqu

Impact of rectal perforation on recurrence during rectal cancer surgery in a national population registry

Background: Incidental perforation in rectal cancer surgery is considered a risk factor for poorer oncological outcome. Most studies emanate from the era before total mesorectal excision when staging, neoadjuvant treatment and surgical technique were suboptimal. This study assessed the impact of incidental perforation on oncological outcome in a cohort of patients with optimized management. Method

Statin use, HMGCR expression, and breast cancer survival – The Malmö Diet and Cancer Study

Statins, commonly used to treat hypercholesterolemia, have also been proposed as anti-cancer agents. The identification of a predictive marker is essential. The 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGCR), which is inhibited by statins, might serve as such a marker. Thorough antibody validation was performed for four different HMGCR antibodies. Tumor expression of HMGCR (#AMAb90619, CL

Negative associations for fasting blood glucose, cholesterol and triglyceride levels with the development of giant cell arteritis

Objectives. To investigate metabolic features that may predispose to GCA in a nested case-control study. Methods. Individuals who developed GCA after inclusion in a population-based health survey (the Malmö Preventive Medicine Project; N ¼ 33 346) were identified and validated through a structured review of medical records. Four controls for every validated case were selected from the database. Re

Long‐term use of aversive drugs in outpatient alcoholism treatment

In a 2‐year outpatient treatment programme for alcoholics, 90% of the patients used aversive drugs during some part of the treatment period. Long‐term use was significantly related to a favourable drinking outcome during 2 years subsequent to treatment compared with short‐term use. Long‐term and short‐term users did not differ in background data. Continued use of aversive drugs after the first 6 m

Prediagnostic serum selenium levels in relation to breast cancer survival and tumor characteristics

Women with lower levels of serum selenium (Se) may have a worse survival in breast cancer than women with higher levels, despite no difference in incidence of the disease. Our study was conducted to test whether Se is associated with the aggressiveness of breast tumors. Both the risk of having a tumor characteristic associated with worse prognosis, as well as the overall and breast cancer-specific

Early and late improvement in a two‐year out‐patient alcoholic treatment programme

Abstract— The process of improvement was studied in a 2‐year out‐patient programme for alcoholics. The drop‐out rate was 16%. The analysis was based on recurrent evaluations of treatment contracts including both drinking pattern and psycho‐social treatment objectives. Background data were related to the alcohol adjustment during the first but not during the second year of treatment. Subjects with

Genomic analysis of european drosophila melanogaster populations reveals longitudinal structure, continent-wide selection, and previously unknown DNA viruses

Genetic variation is the fuel of evolution, with standing genetic variation especially important for short-term evolution and local adaptation. To date, studies of spatiotemporal patterns of genetic variation in natural populations have been challenging, as comprehensive sampling is logistically difficult, and sequencing of entire populations costly. Here, we address these issues using a collabora