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Even though B-lymphocyte development is one of the best understood models for cell differentiation in the hematopoetic system, recent advances in cell sorting and functional genomics has increased this understanding further. This has suggested that already early lymphoid primed multipotent progenitor cells (LMPPs) express low levels of lymphoid restricted transcripts. The expression of these genes
Small and medium sized enterprises (SMEs) play an important role in all economies today and although their individual environmental impact is often limited, their total impact can be said to be significant due to their sheer number. Environmental management is a way to reduce the impact, but the results obtained by implementing ISO 14001 vary. The point of departure for this dissertation is the hy
The wish to see beyond the horizon of the human biological eye is one of the major driving forces in the development of medical imaging technology. This essay discusses the implications technology has on the ability to see, and consequently know, more about the body. Further, the potential of merging art, rehabilitation engineering and medicine to develop and use images specifically designed to cr
Infestation of skin by the parasitic itch mite Sarcoptes scabiei afflicts 300 million people worldwide and there is a need for novel and efficient therapies. We have previously identified a multigene family of serine proteases comprising multiple catalytically inactive members (scabies mite-inactivated protease paralogs (SMIPPs)), which are secreted into the gut of S. scabiei. SMIPPs are located i
This thesis was motivated by contradictory results from previous studies on reading describing foreign language learners in upper secondary school. Methods based upon ideas by Palinscar & Brown, Cooper, Beck et al, and Krashen were tested on approximately 200 students studying Spanish in the first two years of upper secondary school in Sweden. The methods used are called reciprocal reading, k
A two-echelon distribution inventory system with a central warehouse and a number of retailers is considered. The retailers face stochastic demand. The system is controlled by continuous review installation stock (R,Q) policies with given batch quantities. There are linear holding costs at all locations and linear backorder costs at the retailers. We present a simple technique for approximate opti
The modern synthesis of genetics with evolution slanted our understanding of evolution and of ourselves by rejecting Darwin’s view of animals as participating in their own evolution. Defining evolution in terms of genetics, the modern synthesis indulges excessive individualism and distorted self-images as self-made. At the same time, such gene-centred thought, evoking images of master molecules ma
Abstract in UndeterminedImmobilized bioelements offer additional sensitivity and/or selectivity in analytical techniques, in biotechnological devices, and in different medical applications. Great research interest has recently been focused in all these fields on miniaturization techniques, special attention being accorded to the patterning of biomolecules (e.g. enzymes) on solid surfaces with micr
The fortified churches of Bornholm: Comments on the article Jes Wienberg, "Bornholms kirker fra den ældre middelalder", reprinted in the same volume of Bornholmske Samlinger; first printed 1986
Stem cell tourism is criticized on grounds of consumer fraud, blatant lack of scientific justification, and patient safety. However, the issues are complex because they invoke questions concerning the limits of acceptable medical innovation and medical travel. Here we discuss these issues and articulate conditions under which "unproven" therapies may be offered to patients outside of regular clini
The main contribution of this work is a novel numerical characterization of a DNA sequence based on the 2-D graphical representation of DNA introduced by Yau et al. [12]. We construct a 3-tuple of the normalized leading eigenvalues of the Q matrices associated with the three characteristic curves of a DNA sequence. The approach is illustrated with an examination of dissimilarities of exon-1 of bet
In 231 diffuse large B-cell lymphomas, the expression of cyclin D1 and CD5 was evaluated. All cases were CD5-. Ten (4.3%) were positive for cyclin D1 and were subjected to fluorescence in situ hybridization at the CCND1 locus. One case showed the t(11;14). In another case, the telomeric probe signal for cyclin D1 was lost in most tumor cells, and in a small proportion of the cells, there were fluo
