Characterization of normal breast stem cells is important for understanding their role in breast development and in breast cancer. However, the identity of these cells is a subject of controversy and their localization in the breast epithelium is not known. In this study, we utilized a novel approach to analyze the morphogenesis of mammary lobules, by combining one-dimensional theoretical models a

Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have functional properties of stem and early progenitor cells. In 72% of ductal carcinoma in situ lesions, an

INTRODUCTION: Although estrogen and progesterone play a key role in normal mammary development and in breast cancer, the potential for proliferation and lineage differentiation as well as origin of cells that express the estrogen receptor (ER) in normal breast epithelium are not known. Some evidence suggests that normal human mammary stem/progenitor cells are ER-, but the identity of these cells a

Mortality of patients with breast cancer is due overwhelmingly to metastatic spread of the disease. Although dissemination is an early event in breast cancer, extended periods of cancer cell dormancy can result in long latency of metastasis development. Deciphering the mechanisms underlying cancer cell dormancy and subsequent growth at the metastatic site would facilitate development of strategies

For Eastern Africa, very little information about the SSH knowledge production can be found from a European perspective. Adequate indicators like information-rich bibliographic databases that cover East-Africa-based journals and book publishers are lacking. This research in progress explores their indexing situation in detail, their development, which is closely connected to political history, the

We consider the problem of controlling the transmission rate in a communication network where each node adjusts its own transmission rate exclusively based on the physical medium occupation (the band occupancy of the aggregate complementary nodes). We show how to design a decentralized control for maximizing both band occupancy and fairness. If the network is fully connected, the problem admits a

We propose a novel approach to the problem of inverse kinematics for possibly redundant planar manipulators. We show that, by considering the joints as point masses in a fictitious gravity field, and by adding proper constraints to take into account the length of the links, the kinematic inversion may be cast as a convex programming problem. Convex constraints in the decision variables (in particu

The problem of synthesizing network-decentralized observers arises when several agents, corresponding to the nodes of a network, exchange information about local measurements to asymptotically estimate their own state. The network topology is unknown to the nodes, which can rely on information about their neighboring nodes only. For homogeneous systems, composed of identical agents, we show that a

Given a static plant described by a differentiable input-output function, which is completely unknown, but whose Jacobian takes values in a known polytope in the matrix space, this paper considers the problem of tuning (i.e., driving to a desired value) the output, by suitably choosing the input. It is shown that, if the polytope is robustly non-singular (or has full rank, in the non-square case),

Oscillators are essential to fuel autonomous behaviours in molecular systems. Artificial oscillators built with programmable biological molecules such as DNA and RNA are generally easy to build and tune, and can serve as timers for biological computation and regulation. We describe a new artificial nucleic acid biochemical reaction network, and we demonstrate its capacity to exhibit oscillatory so

In a world where predictive big data analytics and data driven policy and design are increasingly prevalent, the concept of broken data seeks to interrogate and disrupt the possibilities associated with these trends. Concepts of breakage, damage and repair, and recent literatures about ‘broken world’ type theories, offer us an alternative starting point: what are the implications of putting these

In a world where predictive big data analytics and data driven policy and design are increasingly prevalent, the concept of broken data seeks to interrogate and disrupt the possibilities associated with these trends. Concepts of breakage, damage and repair, and recent literatures about ‘broken world’ type theories, offer us an alternative starting point: what are the implications of putting these

September 19th 2015 the exhibition/installation Multistable Fields opened in the atrium of the main building at Lund university. Here’s the synopsis:The main building of Lund University was inaugurated in 1882. In the building conceived by architect Helgo Zettervall the rational quest for knowledge of Academia is enmeshed with a world of mythical symbols. Sphinxes and griffins meet deans and profe

Fieldnotes is an exploration of imaginary geographies. It is a series of surreal short films examining how the concept of ethnographic fieldnotes can be related to places, situations and the way ethnography is communicated. Each film in the series is also an evocation, based on video recorded at a single location at a single time. The video is then composited and soundtracked into a surreal accoun