High-throughput sequencing was applied to investigate the mutation/methylation patterns on 1q and gene expression profiles in pediatric B-cell precursor acute lymphoblastic leukemia (BCP ALL) with/without (w/wo) dup(1q). Sequencing of the breakpoint regions and all exons on 1q in seven dup(1q)-positive cases revealed non-synonymous somatic single nucleotide variants (SNVs) in BLZF1, FMN2, KCNT2, L

Special issue of "Culture Unbound". Through six original articles, the issue investigates a variety of cultural and scientific discourses and practices that in different ways are related to neuroscience and the brain.

Cloud computing has emerged as an inexpensive and powerful computing paradigm, to the point that now even applications with hard deadlines are executed in the cloud. It may happen, due to unexpected events, that an application becomes popular and receives a lot of attention and client requests in a short period of time. Provisioning computing capacity for such applications is quite a difficult tas

Objectives. To describe glucocorticoid (GC) use in the SLICC inception cohort and to explore factors associated with GC use. In particular we aimed to assess temporal trends in GC use and to what extent physician-related factors may influence use. Methods. Patients were recruited within 15 months of diagnosis of SLE from 33 centres between 1999 and 2011 and continue to be reviewed annually. Descri

This paper is based on a roundtable discussion held in September 2016 as part of the Pedagogical Inspiration Conference for teachers at the Faculties of Humanities and Theology at Lund University (LU). The roundtable was meant to focus specifically on the consequences of the lack of permanent teaching positions for the quality of the pedagogical work carried out at LU. However, as will be discusse

Recent neuroscientific and technical developments of brain machine interfaces have put increasing demands on neuroinformatic databases and data handling software, especially when managing data in real time from large numbers of neurons. Extrapolating these developments we here set out to construct a scalable software architecture that would enable near-future massive parallel recording, organizati

The BOADICEA breast cancer (BC) risk assessment model and its associated Web Application v3 (BWA) tool are being extended to incorporate additional genetic and non-genetic BC risk factors. From an online survey through the BOADICEA website and UK, Dutch, French and Swedish national genetic societies, we explored the relationships between the usage frequencies of the BWA and six other common BC ris

Introduction: Roux-en-Y gastric bypass (RYGB) causes more rapid and enhanced absorption of alcohol. RYGB patients have also been reported to use more inpatient care for alcohol-related disease than do patients after other bariatric procedures. The present study was designed to evaluate alcohol consumption level before and after gastric bypass using a sensitive and specific alcohol biomarker. Mater

Galectin-9 consists of two peptide-linked carbohydrate recognition domains (CRDs), but alternative splicing and proteolytic processing can give rise to multiple galectin-9 isoforms. Some of these consist of a single CRD and can exert different functions in cell biology. Here, we explored the role of these galectin-9 isoforms in endothelial cell function and angiogenesis. For this, we compared the

Childhood cancer survivors face risks from a variety of late effects, including cardiac events, second cancers, and late mortality. The aim of the pan-European PanCare Childhood and Adolescent Cancer Survivor Care and Follow-Up Studies (PanCareSurFup) Consortium was to collect data on incidence and risk factors for these late effects among childhood cancer survivors in Europe. This paper describes

The aim of this article is to analyse popular neuroimaging of (dis)able(d) brains as a cultural phenomenon, as well as to explore how there has been, during the last decades, a subtle but important change in the way “normal” brains are depicted in popular science. Popular neuroimaging is introduced and used as an empirical basis to analyse what Fiona Kumari Campbell sees as a critique against able

Ferrofluids based on insulating liquids are intensively studied as a potential substitute of liquid dielectric in high voltage technologies. In this work we focus on the experimental investigation of flow and thermal transport characteristics of a ferrofluid based on transformer oil (Mogul) and iron oxide nanoparticles. The magneto-rheological behavior of the ferrofluid was studied by a rotational

The aim of this study was to investigate hydrogen mobility within innate and demineralized human dentine. Dentine sections from extracted human molars, demineralized or not, were analyzed by combining neutron spectroscopy with thermal analysis. For the thermal analysis of the samples, differential scanning calorimetry and thermal gravimetric analysis, coupled with Fourier transform infrared spectr

A model of (Formula presented.) atmospheric transport in vegetated canopies is tested against measurements of the flow, as well as (Formula presented.) concentrations at the Norunda research station located inside a mixed pine–spruce forest. We present the results of simulations of wind-speed profiles and (Formula presented.) concentrations inside and above the forest canopy with a one-dimensional

The design of buildings using multilayer constructions poses a challenge for fire safety and needs to be understood. Narrow air gaps and cavities are common in many constructions, e.g. ventilated façade systems. In these construction systems flames can enter the cavities and fire can spread on the interior surfaces of the cavities. An experimental program was performed to investigate the influence

An atmospheric pressure aerosol-based wet thin film coating technique called the nFOG is characterized and applied in polymer film coatings. In the nFOG, a fog of droplets is formed by two air-assist atomizers oriented toward each other inside a deposition chamber. The droplets settle gravitationally and deposit on a substrate, forming a wet film. In this study, the continuous deposition mode of t