The lysosomal cysteine proteinase cathepsin B is shown to be secreted by ten human colon carcinoma cell lines and to accumulate in culture media as a latent enzyme. The cell lines also secrete a physiological inhibitor of cathepsin B, cystatin C. A significant correlation was found between secretion of the latent enzyme and the inhibitor (r = 0.755, P < 0.01). The aim of the present study was to m

This paper presents a methodology with the purpose of modeling and simulating outdoor temperature and relative humidity (vapor concentration) related to moisture exposure on timber structures. The methodology is based on time-series analysis with recorded meteorological data used as input. In situations where recorded data is missing or consists of limited sequences, this methodology offers the po

The phase and electrochemical behavior of the aqueous mixtures of monoolein (MO) and synthetic ferrocene (Fc) derivatives containing long alkyl chains -(Z)-octadec-9-enoylferrocene (1), (Z)-octadecen-9-ylferrocene (2), and ferrocenylmethyl (Z)-octadec-9-enoate (3)-were studied. At low hydration, the reversed micelles (L-2 phase) and cubic Q(230) phase of MO can accommodate relatively high amounts

The matrix Riccati equation appears in many optimal control and filtering problems. In this paper the Riccati equation is studied from an algebraic point of view, and the results are applied on optimal control of linear time invariant systems with quadratic loss.

Popular Abstract in Swedish Åderförkalkning i benens artärer ger upphov till "fönstertittarsjuka" och, i svåra fall, kritisk ischemi med vilosmärtor och sår eller kallbrand. I dessa sistnämnda fall är risken för en amputation stor. Kärlkirurgiska metoder med s.k. bypassoperationer användes för att söka rädda benen. För detta ändamål används helst patientens egna vener, men i vissa fall måste man aThe expression of surface adhesion molecules on white blood cells (WBC) and platelets, and the release of tumor necrosis factor-alpha (TNF-a) and interleukin-6 (IL-6) after incubation with expanded-polytetrafluoroethylene (ePTFE)- or woven Dacron grafts was determined. Both graft-materials induced alteration of the WBC adhesion molecule receptor and caused release of TNF-a and IL-6, higher for wov

Abstract not available

Semen quality has been reported to vary markedly between different regions. To properly assess the differences among countries a minimization of the variation among centres in the assessments of sperm quality is essential. We here report on the training and two subsequent follow-up workshops on assessments of sperm concentration and motility. A total of 26 fresh ejaculates were analysed by four pe

The material in Swedish herbaria previously identified as Hieracium sublividum (Dahlst.) Johanss. was revised using both the traditional taxonomical approach and PCA analysis based on 44 morphological characters. Only about half of the specimens did belong to H. sublividum s. stricto (known from the provinces Småland, Öland and Östergötland). Three new species were revealed and are described anew

This paper addresses variations in the wind climate in relation to changes in the impact of wind erosion on agricultural lands with Scania, the southernmost province of Sweden, as an example. The literature concerning wind erosion in the region is reviewed and the conclusions are linked to recent analyses of the regional wind climate. Presently, wind erosion occasionally induces problems in light

The role of islet constitutive nitric oxide synthase (cNOS) in insulin-releasing mechanisms is controversial. By measuring enzyme activities and protein expression of NOS isoforms [i.e., cNOS and inducible NOS (iNOS)] in islets of Langerhans cells in relation to insulin secretion, we show that glucose dose-dependently stimulates islet activities of both cNOS and iNOS, that cNOS-derived nitric oxid

Structural biology has transformed a number of fields of biochemistry and biology. A few examples are the following. The allosteric uptake and release of oxygen from haemoglobin obtained an elegant description from the work of Perutz [ Perutz ( 1970), Nature ( London), 227, 726 - 739; Perutz et al. ( 1998), Annu. Rev. Biophys. Biomol. Struct. 27, 1 - 34]. The structure of tRNA highlighted the fact

High-resolution capacitance measurements were used to explore the effects of the gut hormones GLP-I(7-36) amide [glucagon-like peptide I(7-36) amide] and GIP (glucose-dependent insulinotropic polypeptide) on Ca2+-dependent exocytosis in glucagon-secreting rat pancreatic alpha-cells. Both peptides produced a greater than threefold potentiation of secretion evoked by voltage-clamp depolarizations, a

Aim: To identify early predictors of outcome in infants born at 25 gestational weeks. Material and Methods: Data from a regional perinatal database (time-period 1995-2001, total n = 108 000 births) were used. Apgar scores were available in 92 preterm infants, born at 25 + 0 to 25 + 6 gestational weeks, and analyzed in relation to short-term outcome (180-day survival with, or without, severe brain

Dynorphin B (dyn B) in trigeminal ganglion cells and in perivascular nerve fibers in pial arteries was demonstrated in rat, guinea-pig, and monkey by immunohistochemistry. The pathway from the trigeminal ganglion, which runs via the nasociliary nerve and ethmoidal foramen to the pial arteries, was shown in rat by retrograde tracer technique and nerve section. In the guinea-pig the peptide was demo