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Affordable housing production for low income groups by land use zoning plans in harbor areas of Copenhagen

Housing expenses have the highest share in household budgets of low-income groups in Copenhagen leading to affordability problems. To provide affordable housing (AH) for low-income groups, the municipality developed a zoning plan in 2015 aimed to reserve up to 25% of land for new AH production. This qualitative case study compares the affordability of homes produced by private sector and nonprofit

Conveying meaning in legal language : Why the language of legislation needs to be more explicit than ordinary language

In current debate, a considerable amount of attention is given to the question of whether theories of verbal communication that apply to ordinary communicative exchanges - inparticular Grice’s conversational model - likewise apply to legal contexts. In Grice’s analysis, implicit contents are conveyed by speakers, as well as correctly interpreted by hearers, because ordinary conversations are assum

Grain boundary and particle interaction: Enveloping and pass-through mechanisms studied by 3D phase field crystal simulations

Grain boundary interaction with second-phase particles having different degrees of coherency is investigated using the phase field crystal (PFC) method. Both the enveloping and pass-through mechanisms are studied with regards to grain boundary pressure, passage time and interface evolution. It is found that coherent particles exert a stronger retardation effect on grain boundaries compared to incoGrain boundary interaction with second-phase particles having different degrees of coherency is investigated using the phase field crystal (PFC) method. Both the enveloping and pass-through mechanisms are studied with regards to grain boundary pressure, passage time and interface evolution. It is found that coherent particles exert a stronger retardation effect on grain boundaries compared to inco

Understanding the Experience of Code Review: Misalignments, Attention, and Units of Analysis

Code review is a common practice in software development andnumerous studies have described different aspects of the process;its characteristics, the expectations on that process, issues aroundreviewer allocation, and more. However, one aspect that has notbeen studied to a large extent is the experience of the developersin the code review process. This is unfortunate given the signifi-cant amount

What’s bothering developers in code review?

The practice of code review is widely adopted in industry and hasbeen studied to an increasing degree in the research community.However, the developer experience of code review has receivedlimited attention. Here, we report on initial results from a mixed-method exploratory study of the developer experience.

Knee replacement revision: an international comparison

AbstractBackground and purpose: The need for knee replacement revision arises from a combination of patient, prosthesis and surgeon factors. Registry data can help study these relationships. Pooling data from multiple registries may increase both reliability and generalizability. The study aim was to gain a multi-national overview of knee replacement revision, to inform best-practice and improve o

Entering non-platformized sectors: The co-evolution of legitimacy debates and platform business models in digital health care

Digital platforms have deeply transformed a wide variety of sectors. However, new platform business models often face critical legitimacy challenges. Consequently, new entrants must continuously design and redesign their business model components, particularly when entering non-platformized sectors that are highly regulated. We draw on a longitudinal case study of the emergence of digital healthca

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This article provides an overview of the Belt and Road Initiative’s (BRI) current progress, as well as the challenges and uncertainties it faces on the national and international level. At the same time, it notes that the Chinese Communist Party continues to show resilience in its promotion of the initiative. Finally, it argues that we will likely see the BRI develop in new, experimental ways in t

Zoledronic Acid Targeting of the Mevalonate Pathway Causes Reduced Cell Recruitment and Attenuates Pulmonary Fibrosis

Background and aim: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease causing irreparable scarring of lung tissue, with most patients succumbing rapidly after diagnosis. The mevalonate pathway, which is involved in the regulation of cell proliferation, survival, and motility, is targeted by the bisphosphonate zoledronic acid (ZA). The aim of this study was to assess the antifibroti

Innate Immune Responses to RSV Infection Facilitated by OGG1, an Enzyme Repairing Oxidatively Modified DNA Base Lesions

The primary cause of morbidity and mortality from infection with respiratory syncytial virus (RSV) is the excessive innate immune response(s) (IIR) in which reactive oxygen species (ROS) play key role(s). However, the mechanisms for these processes are not fully understood. We hypothesized that expressions of IIR genes are controlled by the ROS-generated epigenetic-like mark 7,8-dihydro-8-oxo(d)gu

Towards a treatment for mitochondrial disease : current compounds in clinical development

Primary mitochondrial diseases are a heterogeneous group of rare genetic disorders affecting approximately 125 persons per million. Mutations underlying these diseases give rise to biological changes (including decrease in cellular energy production and increase in reactive oxygen species), leading to organ failure, and commonly early morbidity. Mitochondrial diseases often present in early childh

Challenges imposed by the COVID-19 pandemic on the Obstetrics and Gynecology residency program : a mixed-methods Swedish survey in the COPE Staff cohort study

BACKGROUND: To outline how the training program and work situation of residents in Obstetrics and Gynecology (OB-GYN) was affected by the pandemic and to illuminate how residents experienced these changes.METHODS: As part of the COVID-19 in Pregnancy and Early Childhood Staff (COPE Staff) cohort study, between January and May 2021, all participating residents were invited to answer a 28-question o

IRF8 deficiency induces the transcriptional, functional, and epigenetic reprogramming of cDC1 into the cDC2 lineage

Conventional dendritic cells (cDCs) consist of two major functionally and phenotypically distinct subsets, cDC1 and cDC2, whose development is dependent on distinct sets of transcription factors. Interferon regulatory factor 8 (IRF8) is required at multiple stages of cDC1 development, but its role in committed cDC1 remains unclear. Here, we used Xcr1-cre to delete Irf8 in committed cDC1 and demons

Predictors of Safety Climate Outcomes in Firefighting

Safety climate refers to the perceived value an organization places on safety at a specific point in time. To determine key predictors of safety climate in the fire service, we distributed a questionnaire to 105 career firefighters in a Swedish city of approximately 110,000 and analyzed their responses. We used these data to investigate the role of individual, work-group, and organizational factor

A hybrid type I, multi-center randomized controlled trial to study the implementation of a method for Sustained cord circulation And VEntilation (the SAVE-method) of late preterm and term neonates : a study protocol

BACKGROUND: An intact umbilical cord allows the physiological transfusion of blood from the placenta to the neonate, which reduces infant iron deficiency and is associated with improved development during early childhood. The implementation of delayed cord clamping practice varies depending on mode of delivery, as well as gestational age and neonatal compromise. Emerging evidence shows that infant

The usability of ClimApp : A personalized thermal stress warning tool

ClimApp was developed to assist individuals in reducing the risk of exposure to thermal stress and to supply the user with individualized advice and recommendations. The tool integrates several human thermal models and heat indices with the local weather forecast and goes on to provide users with a prediction of their thermal stress based on their activity level, clothing level, and heat acclimati

A hydrodynamic comparisons of two different high-pressure homogenizer valve design principles : A step towards increased efficiency

Designing more efficient high-pressure homogenizers (HPHs) is important from an industrial perspective (reduce energy cost). Understanding the relationship between valve geometry and breakup is interesting from an emulsification research perspective. Typically, two different design principles are used for commercial HPHs: the traditional outward radial flow design and the newer inward radial flow