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The diffusion of fired bricks in Hellenistic Europe : a similarity network analysis

In this study, similarity networks are used to analyse the diffusion of fired bricks across Hellenistic Europe, initiated in the north Aegean in the fourth century BCE. In a similarity network, archaeological contexts with similar attributes are connected according to a predefined criterion, and the edges are interpreted as potential social or causal links. Here we allow any kind of similarity rel

Performance and robustness trade-offs in PID control

Control design is a rich problem which requires consideration of many issues such as load disturbance attenuation, set-point tracking, robustness with respect to process variations and model uncertainty, and effects of measurement noise. The purpose of this paper is to provide insight into the trade-offs between performance and robustness explicitly. This is accomplished by introducing plots that

Mapping of noise risk zones derived from religious activities and perceptions in residential neighbourhoods in the Cape Coast metropolis, Ghana

Ambient noise levels emanating from religious activities in residential neighbourhoods are an emerging environmental problem that educes little attention from enforcement agencies and policy makers in Ghana. This paper set out to quantify religious noise exposure in urban residential neighbourhoods in the Cape Coast metropolis of Ghana. Subjective annoyance levels of residents in selected communit

Ultrasound-induced acoustophoretic motion of microparticles in three dimensions

We derive analytical expressions for the three-dimensional (3D) acoustophoretic motion of spherical microparticles in rectangular microchannels. The motion is generated by the acoustic radiation force and the acoustic streaming-induced drag force. In contrast to the classical theory of Rayleigh streaming in shallow, infinite, parallel-plate channels, our theory does include the effect of the micro

Condensation and evaporation heat transfer characteristics in horizontal smooth, herringbone and enhanced surface EHT tubes

An experimental investigation was performed to evaluate convective condensation and evaporation of R22, R32 and R410A inside a smooth tube (inner diameter 11.43 mm), a herringbone tube (fin root diameter 11.43 mm) and a newly developed enhanced surface EHT tube (inner diameter 11.5 mm) at low mass fluxes. The inner surface of the EHT tube is enhanced by dimple/protrusion and secondary petal arrays

Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility

Genetic susceptibility accounts for similar to 35% of all colorectal cancer (CRC). Ten common low-risk variants contributing to CRC risk have been identified through genome-wide association studies (GWASs). In our GWAS, 610 664 genotyped single-nucleotide polymorphisms (SNPs) passed the quality control filtering in 371 German familial CRC patients and 1263 controls, and replication studies were co

On the equations of motion in constrained multibody dynamics

The equations of motion for a constrained multibody system are derived from a continuum mechanical point of view. This will allow for the presence of rigid, as well as deformable, parts in the multibody system together with kinematical constraints. The approach leads to the classical Lagrange-d'Alembert equations of motion under constraint conditions. The generalized forces appearing in the equati

Acoustic trapping as a generic non-contact incubation site for multiplex bead-based assays.

In this study, we show a significantly reduced assay time and a greatly increased bead recovery for a commercial Luminex-based multiplex diagnostic immunoassay by performing all liquid handling steps of the assay protocol in a non-contact acoustic trapping platform. The Luminex assay is designed for detecting antibodies in poultry serum for infectious bursal disease virus, infectious bronchitis vi

Moving from ’gut feeling’ to ’pure facts’: launching the ASI interview as part of in-service training for social workers.

Several standardized assessment instruments have been introduced in social work in the last ten years. One of them, the Addiction Severity Index (ASI), is used today in the Swedish social services, and in the Prison and probation services. Swedish state authorities make strong declarations to implement the ASI-interview while critics are sceptic to both its practical relevance and epistemological

Limitations in the Use of Unipolar Charging for Electrical Mobility Sizing Instruments: A Study of the Fast Mobility Particle Sizer

A comparison between three different types of particle sizing instruments (fast mobility particle sizer, FMPS; electrical low pressure impactor, ELPI; and scanning mobility particle sizer, SMPS) and one condensation particle counter (CPC) was made to compare instrument response in terms of size distributions and number concentration. Spherical oil droplets in 39 different sizes, with geometric mea

Search for direct top-squark pair production in final states with two leptons in pp collisions at root s=8 TeV with the ATLAS detector

A search is presented for direct top-squark pair production in final states with two leptons (electrons or muons) of opposite charge using 20.3 fb(-1) of pp collision data at root s = 8 TeV, collected by the ATLAS experiment at the Large Hadron Collider in 2012. No excess over the Standard Model expectation is found. The results are interpreted under the separate assumptions (i) that the top squar

Tapasin and human leukocyte antigen class I dysregulation correlates with survival in glioblastoma multiforme.

Human leukocyte antigen class I (HLA-I) molecules present antigenic peptides to cytotoxic CD8(+) T cells. Downregulation of peptide:HLA-I complexes is common in tumors and results in tumor immune escape variants. Also molecules involved in the maturation of HLA-I have been demonstrated to be dysregulated in malignant neoplasms. We here set out to investigate the antigen presentation capabilities o

Continuing progress on chronostratigraphic subdivision of the Cambrian System

This paper is a review of the chief accomplishments toward defining Cambrian stage- and series-level GSSPs since the founding of the International Subcommission on Cambrian Stratigraphy (ISCS) in 1961, and is an assessment of the Subcommission's progress toward defining the bases of remaining provisional stages and series.

A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse.

Neurogenesis is restricted in the adult mammalian brain; most neurons are neither exchanged during normal life nor replaced in pathological situations. We report that stroke elicits a latent neurogenic program in striatal astrocytes in mice. Notch1 signaling is reduced in astrocytes after stroke, and attenuated Notch1 signaling is necessary for neurogenesis by striatal astrocytes. Blocking Notch s

WONOEP appraisal: Optogenetic tools to suppress seizures and explore the mechanisms of epileptogenesis

Optogenetics is a novel technology that combines optics and genetics by optical control of microbial opsins, targeted to living cell membranes. The versatility and the electrophysiologic characteristics of the light-sensitive ion-channels channelrhodopsin-2 (ChR2), halorhodopsin (NpHR), and the light-sensitive proton pump archaerhodopsin-3 (Arch) make these optogenetic tools potent candidates in c

Dopant Engineering of Inter-Subband Linewidth and Lineshape in Multiwell Heterostructures

We show by numerical diagonalization of the electronic Hamiltonian including screened coulombic impurities that the inter-subband absorption lineshape and linewidth in heterostructures can be controlled by a suitable location of the dopants. We also point out that the usual optical conductivity calculations that employ the self-consistent Born approximation often lead to incorrect lineshapes, alth

Severe Traumatic Brain Injury Management and Clinical Outcome Using the Lund Concept.

This review covers the main principles of the Lund concept for treatment of severe traumatic brain injury. This is followed by a description of results from clinical studies in which this therapy or a modified version of the therapy has been used. Unlike other guidelines, which are based on meta-analytical approaches, important components of the Lund concept are based on physiological mechanisms f