Maturity-onset diabetes of the young (MODY) is a heterogeneous single gene disorder characterized by non–insulin-dependent diabetes, an early onset and autosomal dominant inheritance. Mutations in six genes have been shown to cause MODY. Approximately 15–20% of families fitting MODY criteria do not have mutations in any of the known genes. These families provide a rich resource for the identificat

The electrocatalytic properties for NADH oxidation of five organic dyes, two indophenol derivatives (2,6-dichlorophenolindophenol and indophenol) and three o-quinone derivatives (phenanthrenequinone, pyrroloquinoline-quinone, and 1,2-naphthoquinone) were compared when adsorbed on zirconium phosphate entrapped in carbon paste. The electrochemical behavior of the immobilized dyes was investigated wi

Studies were conducted to elucidate co-receptor spectrum and function of the inflammatory receptor, CMKLR1/ChemR23, which was recently identified as the receptor for the cystatin-like chemoattractant, TIG2, also named chemerin. An infection model was applied based on stably transfiected NP-2.CD4 host cells expressing various co-receptor constructs and exposed to panels of HIV-1, HIV-2 and SIV prim

Adenocarcinomas of the kidney are rare childhood tumors. Only 30 cases with chromosomal abnormalities have been reported, and neither their karyotypic characteristics nor the molecular mechanisms behind their pathogenesis are clear, except for a special group of papillary tumors characterized by X-chromosome abnormalities. We have cytogenetically analyzed short-term cultured cells from two pediatr

Wider use of oral anticoagulants has led to an increasing frequency of warfarin-related intracerebral hemorrhage (ICH). The high early mortality of approximately 50% has remained stable in recent decades. In contrast to spontaneous ICH, the duration of bleeding is, 12 to 24 hours in many patients, offering a longer opportunity for Intervention. Treatment varies widely, and optimal therapy has yet

Nowadays the power supplying systems have a fundamental importance for all small and portable devices. For low power applications, there are two main ways for producing power: electrochemical batteries and mini engines. Even though in recent years many developments have been carried out in improving the design of batteries, the energy density of 1MJ/kg seems to be an asymptotic value. If the energ

The influence of temperature (20-50 degrees C) and NaCl on mass transfer of pure water and glucose solution (0.0055 M) using an Alfa Laval NFT-50 nanotiltration membrane has been investigated. Addition of 0.017 M NaCl(aq) increased the membrane permeability in comparison to measurements with pure water. Performing cyclic temperature variations using a membrane pre-treated with 0.20 M NaC](aq) caus

Chiral cyclophanes were synthesized by cyclodimerization of 2,7-diaza-1,2,3,6,7,8-hexahydropyrene N-acylated with l-amino acids through stepwise nucleophilic aromatic substitution of 1,5-difluoro-2,4-dinitrobenzene.

The combination of microwave-induced (2450 MHz) hyperthermia and ionizing radiation was used in 7 patients with superficial malignant tumours, which were considered refractory to other therapy. A newly developed heating system was used, allowing for a maintained temperature at the master probe of 42.5 degrees C +/- 0.5 degrees C during 45 min, but temperature measurements at multiple sites showed

Studies of research utilization have not taken up Janet Weiss's challenge: to make local research utilization policies understandable in institutional contexts. This article presents research from three different policy sectors: the social services; building and planning; and the working life area. The results of the studies are presented as typical patterns of utilization. The purpose of the arti

Numerous linkage studies have indicated chromosome 18q21–22 as a locus of importance for blood pressure regulation. This locus harbors the neural precursor cell expressed developmentally downregulated 4-like (NEDD4L) gene, which is instrumental for the regulation of the amiloride-sensitive epithelial sodium channel (ENaC). In a linkage study of 16 markers (including two single nucleotide polymorph

Popular Abstract in Swedish Dagens storskaliga tillverkning baseras på varor med relativt kort livstid och lågt pris. Vinsterna för tillverkarna kommer från den stora mängden sålda varor. Det finns dock inom många industribranscher krympande vinstmarginaler och många företag söker därför efter nya källor för att uppnå bättre rörelseresultat. Även miljöfrågorna är en utmaning för industrin. VäxandeLife cycle environmental problems have been addressed by a number of strategies. However, the results are mostly lamentable because solutions are searched for within the same paradigms that give rise to the problems. This research questions the vision of linear material growth and searches for ways to sustain economic growth without putting the natural environment under stress. The research explor

External ATP has been proposed to be an autocrine regulator of glucose-stimulated insulin secretion and responsible for the synchronization of the Ca2+ rhythmicity in the P-cells required for a pulsatile release of insulin from the pancreas. The importance of external ATP for glucose-stimulated insulin release was evaluated in rats with the aid of 2-deoxy-N-methyladenosine3,5-bisphosphate (MRS 217

Using angle resolved photoemission we have investigated annealing-induced changes in Ga1-xMnxAs with x=0.05. We find that the position of the Fermi energy is a function of annealing time and temperature. It is also established that the Curie temperature is strongly correlated to the separation between the Fermi level and the valence band maximum. Valence band photoemission shows that the Mn3d spec