The millennial-scale hydroclimate variability in East Asia has been debated for a long time due to the lack of reliable precipitation records from southern China and inconsistent model simulations. Here, we reconstruct a 40-kyr rainfall record for southern China and Taiwan based on enviro-magnetic and clay mineral proxy parameters from a northern South China Sea marine sediment core. Both proxies

Progressive leptomeningeal metastases (LM) are associated with intractable neurological symptoms and a poor prognosis, and effective treatment options are limited. Intrathecal (IT) pemetrexed has been shown to confer clinical benefit in lung adenocarcinoma, yet our understanding of the efficacy and safety of the treatment is limited. We report a patient with a long-standing history of leptomeninge

Intratelencephalic neurons are a crucial class of cortical principal neurons that heavily innervate the striatum and cortical areas bilaterally. Their extensive cortico-cortical and cortico-striatal connectivity enables sensorimotor integration within the telencephalon, but their role in motor control remains poorly understood. Here, we used a chemogenetic approach to explore the role of intratele

Identifying potential moisture damage is crucial for maintenance practices and assurance of well-being of occupants. However, due to limited information availability and standardization, assessing damage prevalence on the building stock scale remains understudied. By combining investigation records and building databases, this study leverages data analytic techniques and machine learning modeling

The serine protease cathepsin G is synthesized during the promyelomonocytic stage of neutrophil and monocyte differentiation. After processing, including removal of an amino-terminal propeptide from the catalytically inactive proform, the active protease acquires a mature conformation and is stored in azurophil granules. To investigate the importance of the proform-conformation for targeting to gr

The Chicxulub asteroid that ended the Cretaceous Era ∼66.05 million years ago caused a prolonged time of global darkness – the impact winter – leading to mass extinctions. Elements from the asteroid, including the platinum group elements (PGEs) osmium, iridium and platinum are known from the globally distributed boundary clay but their carrier elements have so far been unknown. We identify, for th

We present new true triaxial compression data obtained in the ductile regime on Bleurswiller sandstone. The deformed samples show a range of failure modes qualitatively similar to what was reported by earlier experimental studies performed in conventional conditions (axisymmetric compression). In particular, visual inspection and X-ray Computed Tomography imaging reveal compaction localization in

This work presents a data-driven method for learning low-dimensional time-dependent physics-based surrogate models whose predictions are endowed with uncertainty estimates. We use the operator inference approach to model reduction that poses the problem of learning low-dimensional model terms as a regression of state space data and corresponding time derivatives by minimizing the residual of reduc

Attosecond science enables the study of ultrafast dynamics on atomic scales, providing fundamental insights into light–matter interaction. This thesis work aims to advance the development and application of an attosecond light source capable of delivering extreme ultraviolet (XUV) pulses with exceptionally high intensity.High-order harmonic generation (HHG) is a nonlinear process where a strong la

Notch wear often determines tool life when machining stainless steel. Chemical Vapour Deposited (CVD) Al2O3/Ti(C,N) coated cemented carbide tools are the first recommendation for turning of stainless steel. The CVD coating plays a vital role in reducing and delaying tool wear progress. Hence, it is essential to understand the interaction between the initiation of notch wear and the coating degrada

In stainless steel turning, cutting tool life is often limited by excessive localised damage at the depth of cut line, known as notch wear. Previous research revealed that notch wear in CVD (chemical vapour deposition) Al2O3/Ti(C,N) coated WC-Co tools begins as a coating brittle fracture already after 0.3 m of cutting. This paper investigates the impact of cutting tools and workpiece materials on

Drawing on the quest to improve inclusion and social sustainability in urban planning process, a holistic approach on citizen participation in urban development is becoming increasingly important. One sector of society whose democratic rights remain overlooked in participatory action is children. It is therefore imperative to develop methods for processing the children’s rights to express their op

This study examines the security measures implemented by the Pahlavi government in Iran to counter criminal and terrorist activities prior to the 1979 revolution. The research explores the challenges posed by various radical and insurgent groups, including Marxist and Islamist factions, which employed tactics such as assassinations, kidnappings, and sabotage. It also analyzes the role of the Natio

This study proposes to determine the influence of ‘Environmental Knowledge’ (EK), ‘Altruism’ (Atr), ‘Consumer Confidence’ (CC) and constructs of ‘Theory of Planned Behaviour’ (TPB) like Attitude” (Atd), ‘Subjective Norm’ (Sub) and ‘Perceived behavioural control’ (Pbhc) on consumers’ intention to purchase ‘Green Apparel Products’ (GAPI). Moreover, the moderating effect of ‘Perceived Innovativeness’

BackgroundTo enable people with stroke to achieve an active everyday life under altered conditions, the development of self-management programs is essential to facilitate the process of change that individuals must undergo. To improve access to self-management, internet-based solutions have been proposed. The aim of this study was to evaluate the feasibility of a novel internet-based intervention,

Existentiella hot, inklusive hot mot jaget, samhället och planeten, förekommer genom hela livet och utgör en central del av den mänskliga erfarenheten. För att sammanföra kunskap och begrepp om hur människor kan hantera existentiella hot på ett adekvat sätt sammankallade vi en tvärvetenskaplig arbetsgrupp bestående av åtta forskare från fälten psykologi, systematisk teologi, praktisk teologi, reliExistential threats, including threats to the self, society, and the planet, are present throughout the lifespan and form a core element of the human experience. To consolidate knowledge and constructs about how people can adequately respond to existential threats, we convened an interdisciplinary working group, which consisted of eight researchers from the fields of psychology, systemic theology,

1911 beslöt stadsfullmäktige i Malmö enhälligt och utan debatt att införa en kommunal bostadsinspektion. I denna artikel undersöks bostadsinspektionens härkomst genom att följa olika problematiseringar som inspektion sades lösa hos stadens förvaltningar, den lokala arbetarrörelsen och Fredrika-Bremerförbunds-kretsen i Malmö. Undersökningen visar att urbana aktörer som delvis befann sig utanför parIn 1911 the Swedish city of Malmö got its first housing inspection service. It was put forward in a motion by two social-democratic city councillors and supported by conservative councillors as well as by the women’s movement. The vote in the city council passed unanimously and without discussion. This article focuses on how the question of housing was articulated in a way that meant inspections w

Background: Myocardial infarction (MI) is a serious condition that increases with age. It is valuable to identify the reasons why some are affected, and possibly, why different personality traits can be associated with an increased or decreased risk for myocardial infarction. Methods: This is a cross-sectional study based on wave 7 data from the Survey of Health, Ageing and Retirement in Europe (S

Lysozyme is a model system for crystallographers. In this issue of Structure, Ramos et al. report atomic resolution neutron structures of lysozyme, which unambiguously show the protonation states and hydrogen-bonding networks of the active site. This resolves mechanistic questions that have been debated for decades and provides a unique view to a protein at atomic detail.