Background: TCF7L2 is a central transcription factor in the canonical wingless-type MMTV integration site (WNT) signaling pathway, and genetic variants in TCF7L2 have been found to interact with dietary fiber intake on type 2 diabetes risk. Here, we investigate whether other type 2 diabetes genes could be involved in the WNT signaling pathway and whether variants in such genes might interact with

Silicon photomultipliers (SiPMs) are an enabling solid-state technology for low light sensing, with single photon sensitivity and photon number resolving capability. They feature an extremely high internal gain at the 106 level, comparable to photomultiplier tubes (PMTs), with the advantage of low operating voltage (~50 V compared to ~1000 V for PMT) and low energy consumption. The solid-state tec

One mechanism of resistance of prostate cancer (PCa) to enzalutamide (MDV3100) treatment is the increased expression of AR variants lacking the ligand binding-domain, the best characterized of which is AR-V7. We have previously reported that Phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5Kα), is a lipid kinase that links to CDK1 and AR pathways. The discovery of PIP5Kα inhibitor highlight th

Outdoor lighting makes public space accessible after dark and aims to improve the safety of pedestrians. A systematic literature review shows that facial recognition is the most relevant visual task for judging the potential threat of other pedestrians. In the identified literature it has been operationalized as the task of recognising gender; guessing identity or seeing facial features. However,

Vertical InAs nanowire transistors are fabricated on Si using a gate-last method, allowing for lithography-based control of the vertical gate length. The best devices combine good ON- and OFF-performance, exhibiting an ON-current of 0.14 mA/μm, and a sub-threshold swing of 90 mV/dec at 190 nm LG. The device with the highest transconductance shows a peak value of 1.6 mS/μm. From RF measurements, th

This thesis makes a contribution to network theory and how it applies to economics. It consists of three self-contained papers. It predominantly considers how connections between economic entities can affect economic outcomes. In particular, the first two papers examine social learning, in the one case by applying it to portfolio choice, and in the other by conducting an experiment to determine ho

Are capitalists more likely than others to justify ‘immoral’ acts such as bribery ortax evasion? This chapter investigates the conditions under which this is the case.While qualitative studies continue to document the nuances, mechanisms, andpractices of cheating and fraud among capitalists, quantitative work that tests the presence of fraud in modern economic life across a wide range of societies

In this poster presentation, Ι discuss about the urban writing on Athenian walls as a creative medium of intercommunication occurring during the hard times of socioeconomic and political crisis in Greece, the last seven years. Analyzing works of street art both as visual artifacts and as performative practices, I argue that they are not merely representations of the given socio-cultural context th

Table of Contents I. Skinner’s Arguments and Their Merits 117 II. The First Baseline: The Legalistic Approach Behind the UN Draft Norms 122 III. The Second Baseline: The Polycentric Approach Behind the UN Guiding Principles 128 IV. The Third Baseline: The Two-Track, Multi-Channel Legalization Perspective 136 A. The Context of the Third Legalization Baseline 137 B. A BHR Legalization Perspective

The European Union Agency for Fundamental Rights (FRA), the EU bodyresponsible for advising EU institutions on fundamental rights, is equipped with a Fundamental Rights Platform (FRP) to ensure an on-going and structuredexchange of information and feedback between the FRA and Civil Society. Whenthe FRA was founded in 2007, there was little pre-existing knowledge on how todesign such a Platform; he