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Huntington's disease (HD) is a fatal genetic neurodegenerative disorder caused by a CAG triplet repeat expansion in the gene encoding the protein huntingtin. The most studied model of HD, the R6/2 transgenic mouse, replicates many features of the disease. In addition to motor, cognitive, and endocrine dysfunctions, these mice exhibit a progressive disruption of circadian rhythms. This is accompani

The data on biologic effects of nonthermal microwaves (MWs) from mobile telephones are diverse, and these effects are presently ignored by safety standards of the International Commission for Non-Ionizing Radiation Protection (ICNIRP). In the present study, we investigated effects of MWs of Global System for Mobile Communication (GSM) at different carrier frequencies on human lymphocytes from heal

The stopping powers in silicon of heavy ions, with atomic numbers ranging from 4 to 29, have been determined using a time-of-flight elastic recoil detection analysis (TOF ERDA) set-up. In transmission geometry, the energy loss of heavy elastic recoils in the self-supporting silicon foil of known thickness is measured over a continuous range of recoil energies using time-of-flight (TOF) spectrometr

Popular Abstract in Swedish Denna avhandling i socialantropologi ägnas åt analysen av sociala och kulturella processer i Visaginassamhället efter sovjettiden. Visaginas (tidigare Sniechkus) byggdes under sovjettiden, åren 1975-1989, som hemvist för personal vid Ignalinas kärnkraftverk och deras familjer. De flesta invånarna i staden är ryssar som kom till Litauen mellan 1975 och 1989 för att byggaThis thesis focused on an examination of human agency and strategies for responding to rapid social and economic change. Fieldwork was carried out in the community of Visaginas town that was built during the Soviet period in Lithuania. The town is situated next to the Ignalina nuclear power plant. The majority of the town's inhabitants are Russians who immigrated to Lithuania from other areas of t

Antimicrobial peptides are generated during activation of the complement system [Nordahl et al. Proc. Nat1. Acad. Sci. U. S. A. 2004, 101:16879-16884]. Here we show that the anaphylatoxin C3a exerts antimicrobial effects against the yeast Candida. Fluorescence microscopy and electron microscopy analysis demonstrated that C3a-derived peptides bound to the cell surface of Candida, and induced membra

Popular Abstract in Swedish Avhandlingen "Decolonizing the Viking Age", i två volymer, argumenterar för att den skandinaviska vikingatiden kan ses som en teoretisk konstruktion som i allt väsentligt utarbetades under det sena 1800-talet. Detta tankesystem har därefter i allt väsentligt reproducerats till våra dagar. Konstruktionen av vikingatiden påverkades kraftigt av nationalism och evolutionsteDecolonizing the Viking Age 1 argues that the Scandinavian “Viking Age” can be seen as a system of knowledge constructed in the late 19th century and in its basic structures maintained up to the present day. This system of knowledge was heavily influenced by the nationalistic and evolutionary ideas of its time of making and may be described as a colonialism of the past. The book follows the making

Hylander treated 144 species of Hieracium sect. Hieracium found in Scandinavian parks, 132 of which were described for the first time. However, he did not supply any determination key, only a few species were illustrated and hints about the differences between species were few. In addition, the species concept of Hylander was obviously much narrower than what has been agreed upon by those working

Pressurized liquid extraction (PLE) has gained wide acceptance for the extraction of persistent organic pollutants (POPs) from various environmental and biological matrices. This extraction technique was developed to shorten the extraction step, since this is one of the most time-consuming steps in many analytical procedures. When POPs enter the food chain, as in a number of recent food crises, th

This article contributes to discourse-oriented, information-seeking research by showing how discourses, from a neopragmatist perspective, can be explored as tools that people employ when they actively engage in information practices in varied social contexts. A study of nurses and the nursing profession in Sweden is used as an empirical example of such a context, which is in the article understood

We report on experimental absolute oscillator strengths for 18 UV lines of Ru II, obtained by combining laser-induced fluorescence measurements of radiative lifetimes and branching fractions from line intensities in a calibrated Fourier-transform spectrum. HST/GHRS observations of the spectrum of the sharp-lined B star chi Lupi contain six of these lines, for which ''astrophysical'' relative f-val

"Lethal midline granuloma" of the upper airways generally encompasses T-cell lymphoma and Wegener's granulomatosis in Western populations. Treatment and outcome for each is different, but their pathological distinction may not always be possible on routine biopsy specimens. Within a defined population between 1947 and 1994, we found 12 cases of primary sinonasal T-cell lymphoma, all with a CD20-,

Creep and shrinkage are two major problems to be discussed in concrete design. Basic creep is studied during constant loading, temperature and moisture conditions, i.e. no exchange of moisture takes place to or from the specimen during the test period. In this paper an experimental and numerical study of basic creep of High Performance Concrete (HPC) is outlined. For this purpose cylinders and cub

Popular Abstract in Swedish Nästan en miljon nya fall av magsäckscancer diagnostiseras årligen världen över. Även om frekvensen har fallit dramatiskt de senaste åren så är magsäckscancern fortfarande den näst vanligaste orsaken till död i cancer sett ur ett världsperspektiv. Den geografiska variationen av denna cancertyp är anmärkningsvärd med den högsta förekomsten i asiatiska länder såsom Japan,Nearly one million new cases of gastric cancer are diagnosed annually throughout the world. Even though the incidence has fallen dramatically in recent decades, this disease is still the second leading cause of cancer death in a global perspective. The geographic distribution of gastric cancer varies markedly, with the highest rates in Asian countries such as Japan, Korea, and China. This variatio

The extent of degradation of the fungal biomass in forest soil during laboratory incubation was investigated as a measure of ectomycorrhizal (EM) biomass. The method simulates the disappearance of fungal mycelium after root trenching, where the EM fungi, deprived of its energy source (the tree), will start to die off. Incubating a forest humus soil at 25 C resulted in a decrease in the relative pr

We have previously reported that the heparan sulfate-priming glycoside 2-(6-hydroxynaphthyl)-ß-D-xylopyranoside selectively inhibits growth of transformed or tumor-derived cells. To investigate the specificity of this xyloside various analogs were synthesized and tested in vitro. Selective growth inhibition was dependent on the presence of a free 6-hydroxyl in the aglycon. Because cells deficient