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The human antimicrobial peptide LL-37 permeabilizes the plasma membrane of host cells, but LL-37-induced direct effects on mitochondrial membrane permeability and function has not been reported. Here, we demonstrate that LL-37 is rapidly (within 20 min) internalized by human osteoblast-like MG63 cells, and that the peptide co-localizes with MitoTracker arguing for accumulation in mitochondria. Sub

As part of a set of interventions on discomfort feminism, this article addresses how the politics of discomfort informs boundary work in the neoliberalized academic workplace in Switzerland. Departing from the authors’ engagements in a series of workshops on new forms of stress and pressure in academia and the effects of the deteriorating conditions of labor at their department, this article explo

Depression is a common, recurrent disorder. There is a need for readily available treatments with few negative side effects, that demands little resources and that are effective both in the short- and long term. Our aim was to investigate the long-term effectiveness of two different interventions; physical exercise and internet-based cognitive behavioural therapy (internet-CBT), compared to usual

This study assesses the potential of constructed wetland systems to treat tannery effluent (TE) and mixed industry effluent (MIE). After each of the three influent cells acting as settling cells, three treatment cells in horizontal series along with a Control were applied. Each of the cells was subjected to horizontal surface flow and planted with Hemarthria compressa (L.f.) R.Br. (perennial whip

Data utgör idag en kritisk resurs som genom bearbetning och öppet tillgängliggörande kan bidra till och ligga till grund för effektiviseringar, nya innovationer och tillika ett öppnare och mer demokratiskt samhälle. Mycket av detta värde skapas dock först när datan bearbetas, berikas och kombineras med annan data från andra källor utanför sin organisations.Genom öppen samverkan och delning av data

Recently, nonwetting surfaces have attracted explosive attention in the community of dropwise condensation. Prediction models have been used to improve the fundamental understanding of dropwise condensation heat transfer. However, the multiscale heat transfer characteristics of individual droplets and the quantitative heat transfer evaluation of the droplet growth on different condensing surfaces

Several researchers are investigating strategies to lower the emissions and increase the efficiency of combustion engines to reduce the negative impact on the environment and the climate from transportation. The low-temperature combustion (LTC) concept is the basis for some of these high-efficiency, low-emission combustion technologies. To maximize the combustion controllability of engines based o

Aerosol particles are a complex component of the atmospheric system which influence climate directly by interacting with solar radiation, and indirectly by contributing to cloud formation. The variety of their sources, as well as the multiple transformations they may undergo during their transport (including wet and dry deposition), result in significant spatial and temporal variability of their p

Calls for transformative change and participatory modes of knowledge production demand researchers to assume new roles. This paper synthesizes the literature on knowledge co-production and researcher roles to explore challenges for researchers involved in transdisciplinary environmental management projects. Our research methods combine a scoping review and reflections on personal experiences with

Solving grand environmental societal challenges calls for transdisciplinary and participatory methods in social- ecological research. These methods enable co-designing the research, co-producing the results, and co-creating the impacts together with concerned stakeholders. COVID-19 has had serious impacts on thechoice of research methods, but reflections on recent experiences of ‘‘moving online’’

Background. Even though tobacco is one of the most preventable causes of death worldwide, it endangers more than 8 million people yearly. In this context, meta-analyses suggest that a significant part of the general Iranian population over 15 years of age smoke and that there is a need for good screening tools for smoking cravings and urges in Iran. The present study reported the translation and i

Current theories of the glymphatic system (GS) hypothesize that it relies on cerebrospinal fluid (CSF) circulation to disseminate growth factors and remove metabolic waste from the brain with increased CSF production and circulation during sleep; thereby, linking sleep disturbance with elements of CSF circulation and GS exchange. However, our growing knowledge of the relations between sleep, CSF,

When considered separately from cardiovascular disease, stroke is the third leading cause of death in the U.S. and is the leading cause of long-term disability in adults. New approaches that can be offered to the majority of ischemic stroke patients, can be continued throughout post-stroke care, can limit stroke severity, and can complement or even enhance rehabilitation, would transform ischemic

We investigate the possibility of erosion of planetesimals in a protoplanetary disk. We use theory and direct numerical simulations (lattice Boltzmann method) to calculate the erosion of large - much larger than the mean-free path of gas molecules - bodies of different shapes in flows. We find that erosion follows a universal power law in time, at intermediate times, independent of the Reynolds nu

The increased urbanization and human population growth of the recent decades have resulted in the loss of urban green spaces. One policy used to prevent the loss of urban green space is ecological compensation. Ecological compensation is the final step in the mitigation hierarchy; compensation measures should thus be a last resort after all opportunities to implement the earlier steps of the hiera

Ever higher demands on the sealing of rock around underground structures drive the development of cement-based grouts. The results of the previous study demonstrated that it is possible to mill cement to approximately 20 to 25 µm and use it to seal fracture aperture down to approximately 70 µm. Further milling deteriorates the penetrability of the grouts due to the flocculation of the fine particl

The neocortex has a globally encompassing network structure, which for each given input constrains the possible combinations of neuronal activations across it. Hence, its network contains solutions. But in addition, the cortex has an ever-changing multidimensional internal state, causing each given input to result in a wide range of specific neuronal activations. Here we use intracellular recordin

The electromagnetic character of the ΔI=1 transitions connecting the 1- to 0-phonon and the 2- to 1-phonon wobbling bands should be dominated by an E2 component, due to the collective motion of the entire nuclear charge. In the present work it is shown, based on combined angular correlation and linear polarization measurements, that the mixing ratios of all analyzed connecting transitions between

For many years, blood-based biomarkers for Alzheimer's disease seemed unattainable, but recent results have shown that they could become a reality. Convincing data generated with new high-sensitivity assays have emerged with remarkable consistency across different cohorts, but also independent of the precise analytical method used. Concentrations in blood of amyloid and phosphorylated tau proteins

Growing evidence supports the importance of lifestyle and environmental exposures— collectively referred to as the ‘exposome’—for ensuring immune health. In this narrative review, we summarize and discuss the effects of the different exposome components (physical activity, body weight management, diet, sun exposure, stress, sleep and circadian rhythms, pollution, smoking, and gut microbiome) on im