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Mitochondrial DNA (mtDNA) is compacted into dynamic structures called mitochondrial nucleoids (mt-nucleoids), with the mitochondrial transcription factor A (TFAM) as the core packaging protein. We generated bacterial artificial chromosome (BAC) transgenic mice expressing FLAG-tagged TFAM protein (Tfam-FLAGBAC mice) to investigate the mt-nucleoid composition in vivo. Importantly, we show that the T
Biodiversity is increasingly negatively affected by climate warming, making this issue a major conservation concern. Many bird species respond to warming temperatures by shifting distribution ranges, but these shifts often lag behind temperature changes. Protected areas (PAs) can facilitate such shifts, but a growing body of literature suggests that not all PAs facilitate climate warming responses
Aerosolised Polystyrene Latex (PSL) nanoparticles are, due to their well-defined size, spherical shape, and inert surface, useful in many experimental applications, including studies of particle deposition in the human lung. Aerosolising nanoparticles entails added challenges, and nanoparticles can potentially be more hazardous than otherwise equivalent microparticles. The objective of this work w
Background: Registry data used to monitor clinical care need to be reliable, and the process for assuring data quality transparent. Here the auditing process of the Swedish quality registry for cardiac disease, SWEDEHEART, is described. Methods: SWEDEHEART audits have been performed at 4 time-points in 2011 to 2018, with data quality audited in the 3 largest subregistries covering acute coronary s
Purpose: Assess if cystatin C-derived measures of kidney function are associated with mortality in septic- and non-septic intensive care unit (ICU) patients. Methods: Data from adult patients staying >24 h in four ICUs in Sweden from November 2015–December 2018 included. Outcomes were mortality and need for renal replacement therapy (RRT) due to acute kidney injury. Associations between cystatin C
We report 17 new solar activity cycles with periodicities ranging from 1,700 to 18,000 years. Using Bayesian spectral analysis we determined for each cycle period, amplitude and phase for the past 145,000 years. These results were obtained by analyzing 10Be in the 2775 m long EDML ice core from Dronning Maud Land, Antarctica. In addition, we have augmented the 10Be data with synchronous ice accumu
Background: One of the preanalytical factors that can affect the results of arterial blood gas (ABG) analysis is the time from sample collection to analysis. A delay in analysis may affect the results due to factors such as ongoing cellular metabolism within the blood sample, gas exchange between the blood sample and the environment, and temperature changes. ABG analysis can be delayed for various
Online acoustic emission (AE) sensing is a promising nondestructive technique for battery health monitoring. Herein, we report on the ability of AE sensing to differentiate among different chemomechanical degradation events in a TiS2-based model aqueous chemistry. Short and high-frequency AE signals primarily stem from fracture-related degradation of TiS2, such as layer delamination, exfoliation,
Molecular subtyping of pulmonary large-cell neuroendocrine carcinoma (LCNEC) based on retinoblastoma protein (pRb) expression may influence systemic treatment decisions. Current histomorphologic assessments of hematoxylin and eosin–stained tissue samples cannot reliably differentiate LCNEC molecular subtypes. This study explores the potential of deep learning (DL) to identify histologic patterns t
With 23,000 registered participants and unprecedented media attention, the 16th conference of the parties (COP) to the United Nations Convention on Biological Diversity (CBD) in Cali, Colombia, was the largest in the 32-year history of these biannual meetings. In terms of successes, the Cali conference established a new subsidiary body to protect concerns of indigenous communities and local popula
The influence of alkyl chain on the physical and photochemical properties of D-A-π-A-π-A sensitizers (GZ-121 and GZ-124) for dye-sensitized solar cells (DSSCs) was investigated through density functional theory (DFT). Key aspects examined include geometry, optical characteristic, electron injection, intramolecular charge transfer, and dye regeneration. Adsorption models of dye@TiO2, short-circuit
Phlorotannins, the polyphenols mostly found in brown seaweeds, have attracted high attention from the pharmaceutical industry in recent years due to their antioxidant, antibacterial, and anti-inflammatory activities. These properties make them desirable to be utilized in a wide range of therapeutics. Despite their importance, several challenges make their extractability and identification complex,
Organizations may be confronted with both expected and unexpected events that challenge their abilities to provide these services uninterrupted. Traditional strategies based on anticipation and planning are primarily useful for expected events, but for unexpected events, organizations must develop capacities to adapt to situations and conditions not foreseen. As systems and societies are becoming
The process of industrialization is typically associated with urbanization and a large urban-rural gap in productivity and skills. To what extent were these disparities driven by the direct impact on occupational attainment of living in an urban area or the result of the positive self-selection of migrants moving to cities? In this paper, we leverage exceptional Swedish longitudinal data that allo
In this contribution we present the preliminary results regarding laser-driven nuclear isomer-production obtained during the commissioning of 1 PW-E7 experimental area at ELI-NP. The study of nuclear isomers production and their photoreactions has been a subject of lasting interest in the nuclear physics community. Nuclear isomers play a crucial role in the creation of the elements in the Universe
Swedish multifamily housing is dominated by warm-rent apartments, where heating is included in the rent. This, together with low inequality and an extensive social security system, has been argued to protect a large part of the Swedish population from energy poverty. However, during the energy crisis of 2021–2023, energy poverty quickly rose on the public agenda. In this paper, we challenge the do
Background: Substance use disorder (SUD) is associated with elevated suicide risk. The aim was to compare health care contacts as well as clinical and suicide-specific characteristics in individuals with and without substance use issues who died by suicide. Methods: Data were derived from a nationwide medical record review of confirmed suicides in Sweden. In the current study we included individua
This paper reviews the state of knowledge on past and present storms and marine coastal flooding (MCF) events of various origins within the Baltic Sea, which is an economically and environmentally important part of northwestern Europe. We show that the combination of sedimentary, historical and instrumental records provides the most comprehensive insight into the history of storms and MCF. The fre
