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Observer variation in the assessment of the histopathologic diagnosis of acute appendicitis
Background: The objectives of this study were to determine observer variation in the assessment of the histopathologic diagnosis of acute appendicitis. Methods: Two consultant pathologists independently evaluated 415 appendectomy specimens (set I). After a consensus conference at which the observers unified the criteria of the diagnosis of acute appendicitis, another 396 appendectomy specimens (se
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The alcohol patient and surgery
Alcohol abusers have a threefold increased risk of post-operative morbidity after surgery. The most frequent complications are infections, cardiopulmonary insufficiency, and bleeding episodes. Pathogenesis is suppressed immune capacity, subclinical cardiac dysfunction, and haemostatic imbalance. The economic implications of alcohol abuse in surgical patients are tremendous. Interventional studies
Is carbohydrate deficient transferrin a useful marker of harmful alcohol intake among surgical patients?
Objective: To find out whether the biological marker, carbohydrate deficient transferrin (CDT), was helpful in the detection of alcoholic patients in a surgical unit. Design: Prospective open study. Setting: Teaching hospital, Denmark. Subjects: 286 men and 248 women admitted to the department of surgical gastroenterology between March and July 1996. Main outcome measures: Specific interview about
Association between alcoholism and diverticulitis
Preoperative alcoholism and postoperative morbidity
Background: Preoperative risk assessment has become part of daily clinical practice, but preoperative alcohol abuse has not received much attention. Methods: A Medline search was carried out to identify original papers published from 1967 to 1998. Relevant articles on postoperative morbidity in alcohol abusers were used to evaluate the evidence. Results: Prospective and retrospective studies demon
Stress response to endoscopy
Background: Upper gastrointestinal endoscopy is often accompanied by tachycardia, which may lead to myocardial ischaemia. The pathogenesis for tachycardia is unknown, but the classic endocrine stress response may be of importance. Methods: Seventeen patients (median age, 60 years) undergoing diagnostic gastroscopy without sedation or supplemental oxygen therapy were monitored by means of electroca
Effect of preoperative abstinence on poor postoperative outcome in alcohol misusers : Randomised controlled trial
Objective. To evaluate the influence of preoperative abstinence on postoperative outcome in alcohol misusers with no symptoms who were drinking the equivalent of at least 60 g ethanol/day. Design. Randomised controlled trial. Setting. Copenhagen, Denmark. Subjects. 42 alcoholic patients without liver disease admitted for elective colorectal surgery. Interventions. Withdrawal from alcohol consumpti
A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
Streptococcus pneumoniae (pneumococcus) is an asymptomatic colonizer of the nasopharynx in most individuals but can progress to a pulmonary and systemic pathogen upon influenza A virus (IAV) infection. Advanced age enhances host susceptibility to secondary pneumococcal pneumonia and is associated with worsened disease outcomes. The host factors driving those processes are not well defined, in part
Population based cohort study of the association between alcohol intake and cancer of the upper digestive tract
Objective: To examine the relation between different types of alcoholic drinks and upper digestive tract cancers (oropharyngeal and oesophageal). Design: Population based study with baseline assessment of intake of beer, wine, and spirits, smoking habits, educational level, and 2-19 years' follow up on risk of upper digestive tract cancer. Setting: Denmark. Subjects: 15,117 men and 13,063 women ag
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The present population based cohort study investigates the association between alcohol intake and cancer of the upper digestive tract. The design was prospective with baseline assessment of intake of beer, wine and spirits, smoking habits, educational level and 2-19 years' follow up on risk of upper digestive tract cancer (oropharyngeal and oesophageal). During a mean follow up of 13.5 years, 156
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The case of 43 year old man who had numerous contacts with the health care system is reported. Since 1984 he had been treated 95 times for testicular problems at 45 different hospitals including 36 operations for torsion. Computer record systems had only once stopped the patient from going through another unnecessary operation. An alarm in the computer record system with reference to a contact pla
Editorial: Microbial biofilms interacting with host mucosal surfaces
Differential Internalization of Thrombin-Derived Host Defense Peptides into Monocytes and Macrophages
Proteolytic cleavage of thrombin generates C-terminal host defense peptides exerting multiple immunomodulatory effects in response to bacterial stimuli. Previously, we reported that thrombin-derived C-terminal peptides (TCPs) are internalized in monocytes and macrophages in a time- and temperature-dependent manner. In this study, we investigated which endocytosis pathways are responsible for the i
A systematic review of work interventions to promote safe patient handling and movement in the healthcare sector
Objectives. The aim of this systematic review was to describe interventions which promote safe patient handling and movement (PHM) among workers in healthcare by reviewing the literature on their effectiveness for work and health-related outcomes. Methods. Databases were searched for studies published during 1997–2018. Measures were operationalized broadly, capturing outcomes of work and health. O
Mapping the biotic degradation hazard of wood in Europe - Biophysical background, engineering applications, and climate change-induced prospects
Construction using timber has seen a resurgence in light of global climate mitigation policies. Wood is a renewable resource, and engineered wood products are proving to be competitive against concrete and steel while having several advantages. However, while the renewable nature of wood in construction is a beneficial property for climate mitigation policies, the process of biodegradation introdu
Thermal Conductivity of Ionic Liquid-Based Nanofluids Containing Magnesium Oxide and Aluminum Oxide Nanoparticles
A promising nanomaterial, magnesium oxide (MgO) and a commonly studied nanomaterial, aluminum oxide (Al2O3) were used to enhance the thermal conductivity of two ionic liquids, i.e., 1-ethyl-3-methylimidazolium dicyanamide ([emim][DCa]) and 1-ethyl-3-methylimidazolium tricyanomethanide ([emim][TCM]) of potential as heat transfer medium. Effects of nanoparticle material, size, shape as well as mass
Protein extraction from cold-pressed hempseed press cake : From laboratory to pilot scale
Abstract: During the production of industrial hempseed oil, a press cake is formed as a byproduct, which is often used as animal feed although it contains a high amount of protein that could be used for human consumption. Extracting this valuable protein would reduce food waste and increase the availability of plant-based protein. A protein extraction process based on the pH-shift method was adapt