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Both Low and High Serum IGF-I Levels Associate with Cancer Mortality in Older Men.

Background: Although recent population-based studies suggest a U-shaped relationship between serum IGF-I concentration and all-cause mortality, the distribution of death causes underlying this association remains unclear. We hypothesized that high IGF-I levels associate with increased cancer mortality, whereas low IGF-I levels associate with increased cardiovascular disease (CVD) mortality. Metho

Intra- and inter-molecular interactions of human galectin-3: assessment by full-assignment-based NMR.

Galectin-3 is an adhesion/growth-regulatory protein with a modular design comprising an N-terminal tail (NT, residues 1-111) and the conserved carbohydrate recognition domain (CRD, residues 112-250). The chimera-type galectin interacts with both glycan and peptide motifs. Complete (13)C/(15)N-assignment of the human protein makes NMR-based analysis of its structure beyond the CRD possible. Using t

Sickness Insurance: Design and Behavior

Popular Abstract in Swedish De fyra essäerna i Sickness Insurance: Design and Behavior studerar sjukförsäkringens utformning ur både ett empiriskt och ett teoretiskt perspektiv. Den första essän bygger på en enkätstudie och innehåller två delar. I den första delen undersöks människors preferenser för olika utformningar av sjukförsäkringen, där de olika utformningarna förväntas ge ungefär samma kosThe first essay presents the results from a questionnaire study of sickness insurance and sickness absence behavior in Sweden. In the first part, people’s preferences for the design of a sickness insurance are discussed. Three combinations of qualifying days and compensation rates, with approximately the same costs within the insurance system, are compared. From the questionnaire it is concluded t

Access Time Analysis for IEEE P1687

The IEEE P1687 (IJTAG) standard proposal aims at providing a standardized interface between the IEEE Standard 1149.1 test access port (TAP) and on-chip embedded test, debug and monitoring logic (instruments), such as scan-chains and temperature sensors. A key feature in P1687 is to include Segment Insertion Bits (SIBs) in the scan-path to allow flexibility both in designing the instrument access n

The Duration of Negative Pressure Wound Therapy Can Be Reduced Using the HeartShield Device in Patients With Deep Sternal Wound Infection.

Background: Heart rupture resulting in lethal bleeding is a devastating complication associated with negative pressure wound therapy (NPWT) in patients with deep sternal wound infection (DSWI). We have previously reported that the use of a protective HeartShield device in combination with NPWT decreases the risk of damage to the heart. This article presents a retrospective analysis of NPWT duratio

Analysis of giant cell tumour of bone cells for Noonan syndrome/Cherubism-related mutations.

Background: Giant cell tumour of bone (GCTB) is an osteolytic tumour which contains numerous osteoclast-like giant cells and a proliferation of mononuclear stromal cells (MSC). Giant cell-rich osteolytic lesions can also develop in the jaw bones in Noonan syndrome, a cherubism-like developmental abnormality that is transmitted in an autosomal dominant fashion, often because of mutation in the PTP