Huntington's disease (HD) is a genetic neurodegenerative disorder. Since identification of the disease-causing gene in 1993, a number of genetically modified animal models of HD have been generated. The first transgenic mouse models, R6/1 and R6/2 lines, were established 8 years ago. The R6/2 mice have been the best characterized and the most widely used model to study pathogenesis of HD and thera

We propose a test resource partitioning and optimization technique for core-based designs. Our technique includes test set selection and test resource floor-planning with the aim of minimizing the total test application time and the routing of the added TAM (test access mechanism) wires. A feature of our approach is that it pinpoints bottlenecks that are likely to limit the test solution, which is

The report gives a summary of Björn Wittenmark's visits to China and Australia during the academic year1986 /87 . An overview of the research is given together with a summary of impressions during visits at differentuniversities.

New excited states have been observed in the neutron deficient isotope Ag-98 following the Ni-58+Cr-50-->Te-108* heavy-ion reaction. One of these states may be interpreted as a maximum spin aligned state of the pi g(9/2)(-3) nu vg(7/2) configuration. Other possible interpretations within the nuclear shell model are discussed as well.

The intermetallic compounds FeGa3 and RuGa3 were prepared from the elements using a Ga flux and their structures were refined from single-crystal X-ray data. Both compounds crystallize with the FeGa3 structure type (tetragonal, space group P4(2)/mnm, Z=4). Electrical resistivity measurements revealed a semiconducting behavior for FeGa3 and RuGa3, which is in contrast to the good metallic conductiv

Human papillomavirus type 16 (HPV-16) is a major cause of human cancer. Effective prophylactic vaccines are based on type-specific neutralizing antibodies. A major neutralizing epitope has been defined by the monoclonal antibody H16.V5. To investigate the importance of this epitope for overall immunogenicity of HPV-16, HPV-16 virus-like particles devoid of the H16.V5 epitope were engineered by sit

BACKGROUND: Immunohistochemical staining for tumor-associated proteins is widely used for the identification of novel prognostic markers. Recently, a tissue-conserving, high-throughput technique, tissue microarray, has been introduced. This technique uses 0.6-mm tissue core biopsy specimens, 500 to 1000 of which are brought into a new paraffin array block, which can be sectioned up to 100 times. M

We performed a systematic, large-scale analysis of human protein complexes comprising gene products implicated in many different categories of human disease to create a phenome-interactome network. This was done by integrating quality-controlled interactions of human proteins with a validated, computationally derived phenotype similarity score, permitting identification of previously unknown compl

Women in the 19th century in the south of Sweden. Lifestyle, gender relations, women's emancipation

GABA is the main inhibitory neurotransmitter in the mammalian CNS. GABA in the brain is commonly associated with a fast, point-to-point form of signalling called synaptic transmission (phasic inhibition), but there is growing evidence that GABA participates in another, slower and more diffuse form of signalling often referred to as tonic inhibition. Unresolved questions regarding tonic neuronal in

Popular Abstract in Swedish Även om vi kanske inte tänker på det så ofta så är vår förmåga att bedöma likhet av stor vikt, inte minst då det gäller begreppsbildning och generalisering. Denna avhandling handlar om likhet, speciellt geometriska modeller av likhet. I sådana modeller representeras objekt som punkter i abstrakta rum, och likhet svarar (omvänt) mot avstånd i rummen. Avhandlingen tar uThis dissertation examines and discusses some phenomena related to the geometric representation of similarity. It takes its inspiration from the existing body of empirical research within the fields of perceptual and cognitive psychology, but also connects to certain areas of machine learning. The problems discussed concern the modelling of information integration behavior when concepts like asym

En kritisk genomgång av svensk och internationell litteratur kring innemiljöns påverkan på människans hälsa - det område som på engelska sammanfattas under begreppen SBS (Sick building syndrome) och IAQ (Indoor air quality).

In this letter the distribution of slow target associated particles emitted in Au + Emulsion interactions at 11.6 A GeV/c is studied, The three models RQMD, FRITIOF and VENUS are used for comparisons and especially their treatment of rescattering is investigated.

The magnetic moments of the 8(+) yrast state in Zr-86 and the 17/2(-) and 21/2(+) yrast states in Nb-87 have been measured via the IMPAD technique, The nuclei were produced in the Ni-58(S-32,Xp) reaction; the time-integral Larmor precessions were measured after recoil implantation into a polarised Fe foil. The g-factors are used to deduce the character of the g(9/2) Shell alignments within the sta

The effects of UV-C (254 nm), UV-A (365 nm) and broad-band UV (280-380 nm) on guard cells of Vicia faba L. cv. Long Pod were investigated in the presence of white light (450 .mu.mol m-2 s-1). UV-C (7 .mu.mol m-2 s-1) was found to cause leakage of 86Rb+ from guard cells, while UV-A (0.3 .mu.mol m-2 s-1) stimulated increased uptake in these cells. A relatively small stimulatory effect was observed b

This review discusses the complicated two-electron dynamics of a helium atom in an intense, short laser pulse. A helium gas in femtosecond laser pulses at long wave lengths (lambda similar to 700 nm) and high intensities (I similar to 10(15) W/cm(2)) produces surprisingly high numbers of He2+ ions. These laser fields cause large and fast electron oscillations, which makes a solution of the time-de

It has been shown that the potential for environmental, and financial improvements through the increased substitution of inperson meetings by virtual communication is considerable. However, it has also been shown that this potential is not automatically realized by investing in the technology that can enable virtual meetings. This paper describes two case studies that explored the factors that inf

Diatoms from the surface sediments and sediments cores in the Skagerrak-Kattegat were analyzed and the results were presented in four papers and discussions. The broad aims of this thesis are twofold. The first aim is to correlate diatom data from the surface sediments to modern sedimentary environments, and try to find out the relationships between environmental variables such as salinity, temper