Reduced capacity to produce ROS increases the severity of T cell-dependent arthritis in both mice and rats with polymorphisms in neutrophil cytosolic factor 1 (Ncf1) (p47phox). Since T cells cannot exert oxidative burst, we hypothesized that T cell responsiveness is downregulated by ROS produced by APCs. Macrophages have the highest burst capacity among APCs, so to study the effect of macrophage R

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The formation of micro-droplets due to a pulsative micro-jet (width of 40 mu m) is studied using the 3D Navier-Stokes equations for multi-phase flows using the Volume of Fluid (VOF) and Volume of Solid (VOS) models. The droplet formation is studied for different transient velocity conditions and mass rates. The numerical results show reasonable agreement with both analytical theory and experimenta

Rapid improvement of glucose control in diabetics may cause a transient progression of ischemic retinopathy. We report a transient bilateral acute asymptomatic optic disc swelling associated with rapid improvement of metabolic control in a male Type I diabetic. It is d, suggested that the optic disc swelling could be caused n of by a rapid near-normal normalization of the blood glucose.

Software is an increasing and important part of many products and systems. Software, hardware, and system level components have been developed and produced following separate processes. However, in order to improve the quality of the final complex product, requirements and prospects for an automatic integrated process support are called for. Product data management (PDM) has focused on hardware pr

While other companies have a hard time reaching out to universities, leading university reach into Porsche to make substantial contributions to Porsche's innovation leadership. This is why and how Porsche manages to leverage university research in this unique way.

Aims Tumour necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, which is implicated in some metabolic disorders and may play a role in the development of cardiovascular disease. We examined whether plasma TNF-alpha is related to established cardiovascular risk indicators, plasma levels of soluble cellular adhesion molecules and carotid artery intima-media thickness determined by ultra

Popular Abstract in Swedish Populärvetenskaplig sammanfattning Introduktion Adrenokortikotropiskt hormon (ACTH) stimulerar frisättningen av steroid¬hormoner, främst kortisol, från binjurarna. Kortisol är livsnödvändigt och finns alltid i blodet och förhöjs kraftigt vid stress. I början av 90-talet fann vår forskningsgrupp en koppling mellan ACTH och fettomsättningen som inte involverade steroidhAbstract Adrenocorticotrophic hormone (ACTH) has strong and direct lipid-lowering effects in man. All apoB-containing lipoproteins, i.e. VLDL, LDL, Lp(a), are reduced by 25-30%. In contrast, levels of HDL increase about 10%. In hepatic cell cultures, ACTH inhibits expression and secretion of apoB. In this thesis we corroborate that the reduced apoB synthesis, seen in hepatic cell systems, is als

In this paper, we present and compare the two different XUV interferometric techniques using high-order harmonics that have been developed so far. The first scheme is based on the interference between two spatially separated phase-locked harmonic sources while the second uses two temporally separated harmonic sources. These techniques have been applied to plasma diagnostics in feasibility experime

Stable carbon isotope analysis of terrestrial plant leaves preserved in Quaternary lake sediments has the potential to provide high-resolution reconstructions of past climatic conditions. Preferably, delta(13)C measurements should be made on a single leaf component, e.g. cellulose, but this approach is often precluded by limited leaf availability. Previous work suggests that reliable palaeoclimati

Salt-containing membranes based on polymethacrylates having poly(ethylene carbonate-co-ethylene oxide) side chains, as well as their blends with poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP), have been studied. Self-supportive ion conductive membranes were prepared by casting films of methacrylate functional poly(ethylene carbonate-co-ethylene oxide) macromonomers containing lithium

We prove a uniqueness result for autonomous divergence-free systems of ODE's in the plane and give an application to the study of water flows with vorticity.

This essay is a critical reflection on the state of Swedish labor history.

Popular Abstract in Swedish Bibelsynsfrågor har alltid vållat heta debatter. Svenska Missionsförbundet (SMF) utgör inget undantag från den regeln. Där kom bibelsynen att diskuteras med en intensitet som fick tre bibellärare i följd att sluta vid Missionsskolan på Lidingö (där SMF:s blivande pastorer och missionärer utbildades) och lämna samfundet. På den så kallade "Valhallanatten" 1926 diskuteradThis thesis examines to what extent the issue of the views of the Bible was discussed within the Mission Covenant Church of Sweden (MCCS) during the period of 1917-1942, and if there were any conscious and decisive choices of direction concerning this issue, in spite of the fact that the MCCS has no established views of the Bible. In an introductory chapter, the views of the Bible of the great MC

Cellular redox state is an important metabolic variable, influencing many aspects of cell function like growth, apoptosis, and reductive biosynthesis. In this report, we identify NADPH as a candidate signaling molecule for exocytosis in neuroendocrine cells. In pancreatic beta-cells, glucose acutely raised the NADPH-to-NADP(+) ratio and stimulated insulin release in parallel. Furthermore, intracel