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In 1999 and 2004, we published reports on how the introduction of 20 males into a severely inbred and isolated population of Adders (Vipera berus) halted its decline towards extinction. The introduction significantly enhanced the population's genetic variability, which resulted in a dramatic increase in offspring viability and a rapid increase in numbers. Unfortunately, recently a new and unpreced
Electron energy loss spectroscopy (EELS) and cathodoluminescence (CL) have proved during the past few years to be tremendous tools to study surface plasmons in metallic nanoparticles, thanks to an extremely high spatial resolution combined with a broad spectral range. Despite their apparent close resemblance, qualitative differences between EELS and CL have been theoretically as well as experiment
Ferroelectric materials offer a variety of new applications in the field of smart structures and intelligent systems. Accordingly, the modelling of these materials constitutes an active field of research. A critical limitation of the performance of such materials is given when electrical, mechanical, or mixed loading fatigue occurs, combined with, for instance, microcracking phenomena. In this con
Presentation av och kommentarer till ett nyupptäckt originalmanuskript (spexmanus) av Axel Wallengren och John Wigforss.
This work demonstrates single-shot holography with ultrashort XUV pulses. The pulses are generated by high-harmonic generation in an Ar gas cell and focused to produce a strongly divergent reference beam suitable for in-line holography of micrometer size objects. The achieved intensity of the high-order harmonics in the XUV regime is sufficient for single-shot holography with good signal-to-noise
Background: To evaluate the pattern of co-infection of human papillomavirus (HPV) types in both sexes in Sweden. Methods: Cell samples from genital swabs, first-void urine, and genital swabs immersed in first-void urine were collected in the present cross-sectional High Throughput HPV Monitoring study. Overall, 31,717 samples from women and 9,949 from men (mean age 25) were tested for 16 HPV types
Pacini G, Ahren M, Ahren B. Reappraisal of the intravenous glucose tolerance index for a simple assessment of insulin sensitivity in mice. Am J Physiol Regul Integr Comp Physiol 296: R1316-R1324, 2009. First published February 11, 2009; doi: 10.1152/ajpregu.90575.2008.- Mice are increasingly used in studies where measuring insulin sensitivity (IS) is a common procedure. The glucose clamp is labor
The objective of this study has been to develop technologies that can reduce the content of active pharmaceutical ingredients (APIs) and bacteria from hospital wastewater. The results from the laboratory-and pilot-scale testings showed that efficient removal of the vast majority of APIs could be achieved by a membrane bioreactor (MBR) followed by ozone, ozone + hydrogen peroxide or powdered activa
We evaluated the predictive value of interim positon emission tomography (I-PET) after one course of chemoimmunotherapy in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). One hundred and twelve patients with DLBCL were enrolled. All patients had PET/computed tomography (CT) scans performed after one course of chemotherapy (PET-1). I-PET scans were categorized according to Inte
Brevican is known to be an abundant extracellular matrix component in the adult brain and a structural constituent of perineuronal nets. We herein show that brevican, tenascin-R (TN-R) and phosphacan are present at the nodes of Ranvier on myelinated axons with a particularly large diameter in the central nervous system. A brevican deficiency resulted in a reorganization of the nodal matrices, whic
Due to the possibility of increased efficiency and reduced emissions, Homogeneous Charge Compression Ignition (HCCI) is a promising alternative to conventional internal combustion engines. Ignition timing in HCCI is highly sensitive to operating conditions and lacks direct actuation, making it a challenging subject for closed-loop control. This paper presents physics-based, control-oriented modeli
Background: Blood lead concentrations (B-Pb) were measured in 3 879 Swedish school children during the period 1978-2007. The objective was to study the effect of the proximity to lead sources based on the children's home and school location. Methods: The children's home address and school location were geocoded and their proximity to a lead smelter and major roads was calculated using geographical
This thesis aimed to search for etiological clues about cancer of unknown primary(CUP) by gathering novel information. The Swedish national registries were used and CUP cases were identified according to the seventh revision of the International Classification of Diseases. A consistent increase before the late 1990s and a dramatic decrease afterwards were observed for CUP incidence among Swedes,re
Chromosomal translocations play a crucial role in tumorigenesis, often resulting in the formation of chimeric genes or in gene deregulation through position effects. T-cell acute lymphoblastic leukemia (T-ALL) is associated with a large number of such rearrangements. We report the ectopic expression of the 3' portion of EST DA926692 in the bone marrow of a childhood T-ALL case showing a t(2;11)(q1
Enzymatic degradation of model cellulose films pre-treated with antimicrobial agent, 3-(trimethoxysilyl)-propyldimethyloctadecyl ammonium chloride (TMPAC) was investigated. AFM topographical imaging was used to assess the surface morphology, roughness, and thickness of the dried and hydrated model cellulose film. The kinetics of the model cellulose film in the hydrated state, the adsorption of TMP
Background: Improving maternal and reproductive health still remains a major challenge in most low-income countries especially in sub-Saharan Africa. The growing inequality in access to maternal health interventions is an issue of great concern. In Ghana, inadequate attention has been given to the inequality gap that exists amongst women when accessing antenatal care during pregnancy and skilled a
Background: Protein kinase C (PKC) isoforms are potential targets for breast cancer therapy. This study was designed to evaluate which PKC isoforms might be optimal targets for different breast cancer subtypes. Results: In two cohorts of primary breast cancers, PKC alpha levels correlated to estrogen and progesterone receptor negativity, tumor grade, and proliferative activity, whereas PKC delta a
Dissolution rate measurements are important to understand the behaviour of drugs or drug formulations. Many methods for measuring dissolution rates are available and a good choice should be based on method limitations as well as drug characteristics. In the present study the rotating disc method was critically evaluated for dissolution rate measurements, using aspirin and benzoic acid as model sub
