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Background: Previous epidemiologic and genetic studies have suggested a link between Parkinson disease (PD), essential tremor (ET), and restless legs syndrome (RLS). Methods: We describe the clinical, PET, and pathologic characteristics of an extensive kindred from Arkansas with hereditary PD, ET, and RLS. The pedigree contains 138 individuals. Sixty-five family members were examined neurologicall
Some key political challenges today, e.g. climate change, are future oriented. The intergenerational setting differs in some notable ways from the intragenerational one, creating obstacles to theorizing about intergenerational justice. One concern is that as the circumstances of justice do not pertain intergenerationally, intergenerational justice is not meaningful. In this paper, I scrutinize thi
Our point of departure is a new use of the question tag eller hur (or how) „isn‟t it?‟ in Swedish: (i) Eller hur ska vi åka till Italien i sommar? or how shall we go to Italy in summer „We will go to Italy this summer,. won‟t we?‟ We argue that eller hur used in this way is an overt Yes/No-question operator, and that it patterns with visst and nog, which we propose are two other Yes/No-question op
BACKGROUND/OBJECTIVES: Prospective cohort studies have indicated that serum vitamin D levels are inversely related to risk of type 2 diabetes. However, such studies cannot determine the source of vitamin D. Therefore, we examined the association of dietary vitamin D intake with incident type 2 diabetes within the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study in
Perforated vessels in one form or the other are found in ceramic assemblages in most societies from early prehistoric time onwards. They vary greatly in shape and size, indicating a multitude of uses. This paper focuses on a particular type of perforated vessel – the perforated open cylinder, a “vessel” with no base, or rather with rims at both ends. This means that its function as a container is
Recension av Bosse Schön, Hitlers svenska SS-soldater : brev och dagböcker.
Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING Dokumentation om Sjukdomar i sköldkörteln (thyroidea) finns dokumenterade i litteraturen sedan nästan 3000 år tillbaka. Många miljoner människor över hela världen lider av någon typ av sköldkörtelsjukdom, t.ex. förstorad sköldkörtel (struma/goiter), elakartade -, godartade förändringar eller överaktiv körtel (hyperthyreos, Graves’ sjukBackground: Thyroid surgery is the most common endocrine surgical operation and is considered by many to be at the zenith of endocrine surgery. A good hemostasis is mandatory during a thyroid operation and many new devices have been available during the last two decades. Total thyroidectomy, (TT) is now by many surgeons considered the method of choice when treating Graves´ disease (GD) and multino
Abstract in French Cet article présente le contexte culturel et archéologique des os fossiles humains de la Grotte Muierii que nous datons de 30 150 ± 800 14C ans BP (Before Present) ou 34 810 ± 927 cal. ans BP (ans calibrés Before Present), et de la Grotte Cioclovina, datés de 29 000 ± 700 14C ans BP ou 33 540 ± 832 cal. ans BP, dans les Carpates méridionales.. Ils s’insèrent parmi les plus ancieThis paper presents the cultural and archaeological context of the human fossil bones from Muierii Cave, dated by us to the age of 30 150 ± 800 14C years BP (Before Present) or 34 810 ± 927 cal years BP (calibrated years Before Present), and from Cioclovina Cave, dated to the age of 29 000 ± 700 14C years BP or 33 540 ± 832 cal years BP, in the Southern Carpathians. These are among the most ancien
Systemic Lupus Erythematosus (SLE) is characterized by chronic inflammation involving many organ systems. The etiology is unknown and the pathogenesis has not been fully elucidated. Impairments of the immune system and of the mechanisms regulating cell death are commonly seen in SLE patients. Autoantibodies, in particular anti-dsDNA antibodies, are considered hallmarks of SLE, but the ideal biomar
In this article, we review recent theoretical work that has complemented the extensive experimental data available for multicopper oxidases (MCO) and led to the elucidation of the reaction mechanism of this class of enzymes. The MCOs couple four one-electron oxidations of substrates at the mononuclear type 1 copper (Cu-T1) site with the four-electron reduction of dioxygen at the trinuclear copper
Urate oxidase transforms uric acid to 5-hydroxyisourate without the help of cofactors, but the catalytic mechanism has remained enigmatic, as the protonation state of the substrate could not be reliably deduced. We have determined the neutron structure of urate oxidase, providing unique information on the proton positions. A neutron crystal structure inhibited by a chloride anion at 2.3 Å resoluti
The harvest mouse (Micromys minutus) occurs throughout most of continental Europe. There are also two isolated and recently discovered populations on the Scandinavian peninsula, in Sweden and Norway. Here, we investigate the origin of these populations through analyses of mitochondrial DNA. We found that the two populations on the Scandinavian peninsula have different mtDNA haplotypes. A compariso
Hur gestaltades den diskursiva katolska manligheten i Skandinavien under konfessionalismens tidevarv? Och hur förhöll sig de katolska manlighetsidealen till de idéer om manlighet som framträdde inom nordisk folkkyrkokristendom vid samma tid? Dessa frågor har utgjort utgångspunkten för min undersökning om mansideal och manlighetskonstruktioner hos katolska präster, ordensmän och manliga konvertiter
Recension av R. G. Grant (red.), Krigsherrar. Militärhistoriens främsta befälhavare och Richard Holmes (red.), Stora boken om andra världskriget. Från blixtkrig till Hiroshima.
We report results from a large-scale nutrient fertilization experiment along a "megadiverse" (154 unique species were included in the study) 3,000-m elevation transect in the Peruvian Andes and adjacent lowland Amazonia. Our objectives were to test if nitrogen (N) and phosphorus (P) limitation shift along this elevation gradient, and to determine how an alleviation of nutrient limitation would man
There has been much debate on the topic of whether stricter environmental regulations can promote environmental performance and economic performance at the same time. Different researchers have used different indicators to measure environmental performance and economic performance in their empirical studies. However, it is a surprise that few studies have checked the relationship between environme
Studies have shown that microRNAs (miRNAs) are involved in the malignant progression of human cancer. However, little is known about the potential role of miRNAs in breast carcinogenesis. miR-124 expression in breast cancer tissue was measured by quantitative real-time PCR (qRT-PCR). Target prediction algorithms and luciferase reporter gene assays were used to investigate the target of miR-124. Br
