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Background: Prostate cancer patients with pelvic lymph node metastasis (PLNM) have poor prognosis. Based on EAU guidelines, patients with >5% risk of PLNM by nomograms often receive pelvic lymph node dissection (PLND) during prostatectomy. However, nomograms have limited accuracy, so large numbers of false positive patients receive unnecessary surgery with potentially serious side effects. It is i

BACKGROUND: Randomized controlled trials relatively consistently show that restrictive red blood cell (RBC) transfusion strategies are safe and associated with similar outcomes compared to liberal transfusion strategies in critically ill patients. Based on these data, the general threshold for RBC transfusion was changed to 70 g/L at a 9-bed tertiary level intensive care unit in September 2020. Im

Introduction The population-based Inter99 cohort has contributed extensively to our understanding of effects of a systematic screening and lifestyle intervention, as well as the multifactorial aetiology of type 2 diabetes (T2D) and cardiovascular disease. To understand causes, trajectories and patterns of early and overt cardiometabolic disease manifestations, we will perform a combined clinical d

Developing semiconductor devices requires a fast and reliable source of strain information with high spatial resolution and strain sensitivity. This work investigates the strain in an axially heterostructured 180 nm-diameter GaInP nanowire with InP segments of varying lengths down to 9 nm, simultaneously probing both materials. Scanning X-ray diffraction (XRD) is compared with Bragg projection pty

Plastics consist of fossil fuels, from both a feedstock and energy perspective and thus need to decarbonise. This thesis maps and explores the framings and technologies that surround plastics decarbonisation and the potential mitigation pathway of carbon capture and utilisation. Here, three of the main findings are presented.By unpacking how EU policymakers understand issues concerning plastics, t

The textbook was designed as an introduction to RBC at a basic to intermediary level given the novelty of the topic for most readers. Our overriding aim was to offer a concise, but thoughtful and informative presentation of RBC and human rights issues in the Cambodian context. A key consideration was the intended audience: teachers, researchers and students at university level in Cambodia. We also

Human papillomavirus can be contracted by sexually active women. However, only a small proportion of these infections persist and have the potential to progress into cervical cancers, indicating a significant involvement of the immune system in cervical cancer development. Despite this, our understanding of the precise contributions of genes from different immune cell types in cervical cancers rem

Type-2 diabetes (T2D) worsens stroke recovery, amplifying post-stroke disabilities. Currently, there are no therapies targeting this important clinical problem. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are potent anti-diabetic drugs that also efficiently reduce cardiovascular death and heart failure. In addition, SGLT2i facilitate several processes implicated in stroke recovery. However,

This book brings together leading international scholars with the aim of exploring ritual perspectives in the study of contemporary religions. It combines significant theoretical and methodological reflections and applies it to four main fields relevant to the study of contemporary religions: indigeneity; new spiritualities and ecology; lived religion (with Islam and Africa as case studies); and f

When addressing lying and deception in language production, it is imperative to acknowledge that behavioral indicators may play a role. This include evaluation of multiple distinct verbal and nonverbal behavioral indicators, such as gaze cues, pulse rate, hand movements, and manifestations of nervousness. Here, the role of cognitive load during speaking and writing, and how cognitive load due to t

Aquaporins (AQPs), membrane proteins responsible for facilitating water transport, found in plant membrane vesicles (MV), have been related to the functionality and stability of MV. We focused on AQPs obtained from broccoli, as they show potential for biotechnological applications. To gain further insight into the role of AQPs in MV, we describe the heterologous overexpression of two broccoli AQPs