Published 12 November 2019 The scientific debate following the initial formulation of the “bad luck” hypothesis in cancer development highlighted how measures based on analysis of variance are inappropriately used for risk communication. The notion of “explained” variance is not only used to quantify randomness, but also to quantify genetic and environmental contribution to disease in heritability

https://www.lupop.lu.se/article/commonly-used-estimates-genetic-contribution-disease-are-subject-same-fallacies-bad-luck-estimates - 2025-06-29

Published 13 November 2019 Whole-genome sequencing (WGS) brings comprehensive insights to cancer genome interpretation. To explore the clinical value of WGS, we sequenced 254 triple-negative breast cancers (TNBCs) for which associated treatment and outcome data were collected between 2010 and 2015 via the population-based Sweden Cancerome Analysis Network–Breast (SCAN-B) project (ClinicalTrials.go

https://www.lupop.lu.se/article/whole-genome-sequencing-triple-negative-breast-cancers-population-based-clinical-study - 2025-06-29

Published 14 November 2019 A principle goal of research in Oncology is to determine the optimal treatment for our patients. This often takes the form of comparing 2 existing therapies to one another to determine which is superior, or to introduce a new therapy and determine if it is superior or noninferior to the existing standard of care. New publication in Seminars in Radiation Oncology

https://www.lupop.lu.se/article/population-based-observational-studies-oncology-proceed-caution - 2025-06-29

Published 15 November 2019 ICD codes are a highly reliable indicator of tumor location when the specific location code is entered in the EHR. However, non-specific side of colon ICD codes are present for a sizable minority of patients, and structured data alone may not be adequate to support testing of some research hypotheses. New publication in BMC Medical Research Methodology

https://www.lupop.lu.se/article/validation-diagnosis-codes-identify-side-colon-electronic-health-record-registry - 2025-06-29

Published 12 November 2019 This two-week course is divided into two separate course weeks. The course will be arranged as a retreat somewhere in Sweden. Travel costs and accommodation will be covered in relation to the educational activities. The target group is doctoral students (and those who have recently completed their doctoral education) involved in register-based research within their resea

https://www.lupop.lu.se/article/key-concepts-and-principles-design-and-critical-interpretation-nordic-register-based-studies-0 - 2025-06-29

Published 19 November 2019 In conclusion, umbrella reviews provide a comprehensive overview of a specific research topic and are very helpful tools to evaluate the certainty of evidence. These systematic overviews are helpful for the translation of research findings into recommendations, and also for identifying new research directions. New publication in European Journal of Epidemiology

https://www.lupop.lu.se/article/critical-reflection-grading-certainty-evidence-umbrella-reviews - 2025-06-29

Published 20 November 2019 Chronic pain is a common, complex, and distressing problem that has a profound impact on individuals and society. It frequently presents as a result of a disease or an injury; however, it is not merely an accompanying symptom, but rather a separate condition in its own right, with its own medical definition and taxonomy. New publication in British Journal of Anaesthesia

https://www.lupop.lu.se/article/chronic-pain-review-its-epidemiology-and-associated-factors-population-based-studies - 2025-06-29

Published 21 November 2019 The development of paediatric critical care registries, a term we take to include national audits and research databases, has been instrumental in helping us understand the state of children’s critical care and thereby provide a platform for future improvement. Comprehensive datasets enable monitoring of activity and outcomes for audit, safety and service planning. New p

https://www.lupop.lu.se/article/doing-more-less-what-registry-data-tell-us-about-death-picu - 2025-06-29

Published 22 November 2019 Twin registries have developed as a valuable resource for the study of many aspects of disease and society over the years in many different countries. A number of these registries include large numbers of twins with data collected at varying information levels for twin cohorts over the past several decades. New publication in Cambridge Core

https://www.lupop.lu.se/article/twin-registries-moving-forward-and-meeting-future-review - 2025-06-29

Published 15 November 2019 VR har släppt datum för när de öppnar och stänger sina utlysningar 2020. Läs mer här.

https://www.lupop.lu.se/article/datum-vrs-utlysningar-2020 - 2025-06-29

Published 16 November 2019 För er som missade Registerforskning 2019 - nu finns presentationerna online! Läs mer här.

https://www.lupop.lu.se/article/registerforskning-2019-0 - 2025-06-29

Published 10 April 2019 New publication in International Journal of EpidemiologyRead more here

https://www.lupop.lu.se/article/differential-vulnerability-and-susceptibility-how-make-use-recent-development-our-understanding - 2025-06-29

Published 11 April 2019 Epidemiologists face two fundamental and interrelated problems when judging causality: knowledge is fallible, and studies are imperfect. In medicine, this will always leave a degree of uncertainty in scientific judgements. From an epistemological point of view, even randomized trials cannot be regarded as the ultimate proof to establish a causal relation. Given this inheren

https://www.lupop.lu.se/article/long-and-winding-road-causality - 2025-06-29

Published 12 April 2019 Traditional publishing versus sharing results without restrictions has become a fundamental question that involves many different stakeholders, including scientists, librarians, publishers, and research funding organizations. See a panel of international experts discuss the matter. Read more here.

https://www.lupop.lu.se/article/panel-debate-plan-s-and-open-access-way-go-swedish-researchers - 2025-06-29

Published 13 April 2019 Från och med 2019 behöver du som beviljas bidrag från Vetenskapsrådet ha en datahanteringsplan om din forskning genererar forskningsdata. Planen ska beskriva hur data som samlas in och/eller skapas kommer att hanteras under forskningens gång och hur den ska tas om hand efteråt. Läs mer här. Vill du veta mer om datahanteringsplaner, kan du anmäla dig till seminarium i Lund (

https://www.lupop.lu.se/article/vr-staller-krav-pa-datahanteringsplan - 2025-06-29

Published 12 April 2019 Results from the Swedish National Registry are satisfactory and comparable to international standards. Trends over time show increasing resection rates and some improved results. Better collaboration and openness within pancreatic surgeons is an important side effect. New publication in the official Journal of the International Hepato Pancreato Biliary AssociationRead more

https://www.lupop.lu.se/article/first-results-swedish-national-pancreatic-and-periampullary-cancer-registry-0 - 2025-06-29

Published 15 April 2019 This is an open seminar with professor Miguel Hernán A 3 half-day seminar on Causal Inference with Miguel Hernán, professor of Biostatistics and Epidemiology at Harvard School of Public Health.The scheduel is as follow:Monday May 6 at 1-5PMTuesday May 7 at 1-5PMWednesday May 8 at 9-12AMLocation: Arvid Carlsson, Acadmicum, GothenburgRead more here 

https://www.lupop.lu.se/article/learning-what-works-framwork-causal-inference-observational-data - 2025-06-29

Published 16 April 2019 Most respondents used quality indicators from the two cardiovascular NQRs infrequently (<3 times/year). The results indicate that linking registration of quality indicators to using them for QI activities increases their routine use and makes them meaningful tools for professionals. New publication in International Journal for Quality in Health CareRead more here

https://www.lupop.lu.se/article/quality-indicators-and-their-regular-use-clinical-practice-results-survey-among-users-two - 2025-06-29

Published 17 April 2019 The questionnaire measures and detects differences in patient well-being, abilities and judgements of diabetes care, and identifies areas for improvement. To further improve diabetes care, we conclude that patient-reported measures are important supplements to cardiovascular and diabetes complication risk factors, reflecting patient experiences of living with diabetes and d

https://www.lupop.lu.se/article/patient-reported-outcome-and-experience-measures-diabetes-development-scale-models-differences - 2025-06-29

Published 18 April 2019 There has been marked growth in reports addressing exposure-affected time-varying confounding. This was driven by work in a small number of topic areas, with other areas showing relatively little uptake. In addition, despite developments in more advanced methods such doubly robust techniques and estimation via machine learning, implementation has been largely concentrated o

https://www.lupop.lu.se/article/causal-models-adjusting-time-varying-confounding-systematic-review-literature - 2025-06-29