Filtyp
This invention is directed to a method for the preparation of docetaxel having an amorphous, anhydrous crystalline, or hydrated crystalline structure. In accordance with the invention, highly pure amorphous, anhydrous crystalline, or hydrated crystalline docetaxel can be produced with a high yield by using a solvent precipitation method, colloid formation method, etc.
Provided is a method for preparing a taxane derivative, comprising: carrying out condensation of a phenylisoserine derivatives having a protective group introduced thereto or a mixture of isomers thereof, as a side chain, with a baccatin III derivative or 10-deacetyl-baccatin III derivative to obtain a mixture of isomers; separating the isomers via chromatography; and carrying out a reversion of t
This invention is directed to a method for efficiently separating and purifying 13-dehydroxybaccatin III and 10-deacetylpaclitaxel with a high purity of 90% or higher purity, preferably 99.5% or higher purity, from taxane-containing materials such as Taxus species, and the thusly obtained highly pure 13-dehydroxybaccatin III and 10-deacetylpaclitaxel can be used as semi-synthetic precursors of pac
I denna avhandling undersöktes exekutiva funktioner (EF) hos svenska barn och ungdomar. EF definierades som en uppsättning neurokognitiva processer som reglerar kognitiva, emotionella och beteendemässiga aktiviteter, viktiga för målinriktat handlande. EF bedömdes med hjälp av själv-, föräldra- och lärarskattningar av den första och andra upplagan av Behavior Rating Inventory of Executive Function This thesis examines executive functioning (EF) among Swedish youth. EF is defined as a set of neurocognitive processes regulating cognitive, emotional, and behavioral activities essential for goal-directed behavior. I assessed EF using the self-, parent-, and teacher-report forms from the original and second editions of the Behavior Rating Inventory of Executive Function (BRIEF and BRIEF2). A pri
The present invention relates to a method of removing an endotoxin from solution containing basic proteins. More specifically, the method of the present invention comprises the steps of adding the surfactant to solution containing the basic protein obtained from the recombinant microorganism and mixing the resultant, of loading the resultant solution on the cation exchange column, washing the cati
Through the analysis of the case of the Age of Empires IV community, this qualitative study investigates how the communal efforts of the audience can foster inclusivity, and the meaningful participation of women, in the context of contemporary video game play. Through the analysis of nine semi-structured qualitative interviews, this paper reconstructs the ‘Age of Empires IV tale’: as it evolved fr
Research suggests maturing adolescents’ development of Internalizing Problems like Anxiety and Depression, might be due to impaired Executive Functions. However, most knowledge on the topic is non-causal, within clinical context and predominantly focused on Executive Functions assessed with performance tasks and not everyday Executive Problems assessed using questionnaires. Therefore, we cond
This thesis is a theoretical study of thinking with water in relation to feminist theory of care, solidarity and ethics. The thesis is inspired by Astrida Neimanis’ concepts of hydrofeminism (2012) and bodies of water (2017) and has these as its starting point and main theory. The thesis asks: what can we learn from water in relation to relationality, difference, responses to the climate crisis, e
The purpose of this essay has been to examine how consent, victims and perpetrators are constructed in the Swedish daily press in connection with the introduction of the Consent Act in 2018 and five years later, in 2023. Through a critical discourse analysis, based on Fairclough's three-dimensional model, articles from Aftonbladet, Expressen and Dagens Nyheter have been analyzed. The results s
This thesis investigates how community-based food practices for people-on-themove at the EU’s border in Northern France act as practices of care in response to-the violence, neglect, and carelessness of the EU border regime. While existing-critical border and migration literature discuss the nexus of traditionalhumanitarianism and care at the border, less attention has been paid to the-countering
Introduction Distinguishing between homicide and suicide in cases of single stab injuries to the trunk can be challenging, particularly in the absence of clear contextual information. This study aims to address this issue by developing the MODSIT score (Manner of Death in Stab Injuries to the Trunk)—an evidence-based scoring system designed to standardise forensic manner of death assessments. Meth
The rising prevalence of type 2 diabetes among migrant populations from low- and middle-income countries (LMICs) living in high-income countries (HICs) presents a significant public health challenge. Migrants often experience lifestyle changes, socioeconomic disadvantages and barriers to accessing healthcare, which can increase their risk for type 2 diabetes. This review explores the prevention an
The new ACR/EULAR classification criteria for APS differ from the previous Sydney criteria by incorporating a broader range of clinical manifestations beyond venous/arterial thromboembolism and obstetric complications. These include microvascular disease, heart valve disease and thrombocytopenia. We applied both classification systems to a cohort of 139 individuals diagnosed with primary APS in So
This thesis examines how Ellen Nordmark’s Epos (2024) relates to the epic genre. Rather than categorizing the work within a single, fixed genre, I employ close reading to analyze how it comments on, questions, and reformulates conventions on the epic genre. Particular attention is given to how Epos both reveals and reconfigures the epic tradition, and how the text emphasizes oral and aural modes o
Cardiovascular disease is the leading global cause of death. Cardiovascular magnetic resonance (CMR) imaging is the gold standard method for evaluating cardiac function and structure and is thus an important tool for diagnostics in cardiovascular disease. Recently, deep learning (DL) methods have achieved notable developments in various aspects of CMR. The aim of this thesis was to further assess
Mot bakgrund av det konstaterade glappet mellan policy och praktik vid behovsbedömning i svenska som andraspråk undersöker studien hur behovsbegreppet definieras och tillämpas på olika nivåer i skolans styrkedja, samt vilka faktorer som möjliggör respektive försvårar bedömningsprocessen. Utgångspunkten är skolförordningens formulering om det behövs. Tre delstudier genomfördes för att belysa behovs
This study explores how everyday ferry travel in transit spaces create experiences through the interplay of mundane and extraordinary interactions, focusing on the Øresundslinjen ferry between Helsingborg, Sweden, and Helsingør, Denmark. Drawing on the concepts of mundane tourism, the new mobilities paradigm, tourist gaze, and service-scape theories were used to examine the social, spatial, and em
Mer träffsäker datainsamling för framtidens proteser Hur kan vi få en konstgjord hand att kännas mer naturlig att styra? I mitt examensarbete har jag utvecklat ett system som samlar in och analyserar muskelsignaler från underarmen, med målet att förbättra styrningen av proteser. Resultaten visar att metoden ger tydligare och mer användbar information om muskelaktiviteten än enklare, konventionellThis study presents a custom surface electromyography (sEMG) data acquisition system combining the TI ADS1299 analog-to-digital converter, Teensy MicroMod micro-controller, and a Python-based graphical user interface for real-time signal monitoring and guided data collection. The system outperformed the widely used Ninapro dataset across all major classification metrics, demonstrating improved cla
Inspired by Quintilian, John Dewey and Michael Warner, I have developed and examined a pedagogical concept entitled student-driven imitation that seeks to strengthen the rhetorical agency of the individual learner. Student-driven imitation is a text-oriented imitation praxis that nurtures talent individually (Quintilian), is based on personal experience and goal-setting (Dewey), and fosters attent
