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OBJECTIVE: Chronic inflammation of the urinary bladder is associated with the bladder pain syndrome. The treatment alternatives in humans are far from satisfactory and need further attention. Well-established preclinical models have shown that pro-inflammatory cytokines contribute to the progress of the inflammatory response behind pain and hyperalgesia. Previously presented results indicate that
The issue of riba, or interest, is crucial for both Islamic and non-Islamic countries. Western economic systems use the interest rate to efficiently distribute financial resources for investment and/or consumption. In the entire economic system outside the Islamic countries, interest rates are practically a prerequisite, for the functioning of the economic system. Islamic economies, on the contrar
I rapporten undersöks hur kommuner och regioner kan stärka sin ledningsförmåga – det vill säga förmågan att samordna beslutskraft och handlingskraft – i en tid präglad av komplexa samhällsutmaningar, begränsade resurser och höga krav på legitimitet och effektivitet. Rapporten baseras på intervjuer med ledande politiker och tjänstepersoner i åtta kommuner och tre regioner. Rapportens utgångspunkt äThis report examines how municipal and regional authorities can strengthen their capacity for leadership—that is, their ability to coordinate decisiveness with effective action—in a context characterised by complex societal challenges, constrained resources, and high demands for legitimacy and efficiency. The report is based on interviews with senior elected representatives and public officials in
The conversion of a blood meal into viable offspring is a central physiological challenge for female mosquitoes. A new study has found that rectal pad cells function as a peripheral neuroendocrine hub, sensing feeding-related signals and regulating reproductive investment, linking the hindgut to reproductive decision-making.
Diel rhythms synchronized to Earth's photic cycle are near-ubiquitous among animals living in regions with distinct day-night cues. Where such cues are reduced or absent, however, activity patterns may weaken, reorganize or become decoupled from the light-dark cycle, which may allow for more flexible behavioural expression. Using a dataset of >900 free-ranging black-legged kittiwakes from colonies
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease caused by the selective loss of upper and lower motor neurons. There is a considerable variability in the disease progression of sporadic ALS, but the molecular basis for phenotypic heterogeneity remains largely unknown. ALS patients often manifest systemic metabolic abnormalities such as glucose intolerance and hyperme
Transposable elements (TEs) comprise nearly half of mammalian genomes and have shaped genome architecture, chromatin organization, and transcriptional landscapes. Thanks to recent advances in long-read sequencing and functional (epi)genomics, the focus has shifted from TE families to individual TE loci, revealing widespread, locus-specific regulatory roles. While most TEs have lost the capacity to
Wearable eye tracking in unconstrained settings is often compromised by slippage, yet the direct relationship between physical frame displacement and gaze error remains unexplored. This study addresses this gap combining eye tracking and motion capture to evaluate the slippage robustness of Pupil Labs Neon, Tobii Pro Glasses 3 and ViewPointSystems Lite eye trackers. Data were collected as twelve p
Levodopa-induced dyskinesia (LID) is a debilitating complication of symptomatic therapy in Parkinson's disease. Although there is compelling evidence that striatal pathophysiology is a major driver of LID, the specific circuit mechanisms governing its expression remain obscure. To address this gap, molecular, cellular, and behavioral strategies were used to interrogate circuits in a mouse model of
This position paper examines the growing dominance of health economics in Swedish healthcare governance and argues that its elevated epistemic authority produces significant risks for the sustainability and ethical integrity of care systems. Drawing on feminist theories of care and critical political economy, the paper interrogates the assumption that care can be adequately represented, valued, or
Background: Upper tract urothelial carcinoma (UTUC) is rare, and contemporary data on real-world healthcare resource utilisation and costs are limited. The objective of this study is to describe long-term healthcare resource utilisation among patients with upper tract urothelial carcinoma (UTUC) and to identify clinical and treatment-related drivers of costs. Methods: We conducted a retrospective,
In this study we compared the latencies and amplitudes of pupillary light responses, recorded by a Tobii Pro Spark eye-tracker and a setup combining PupilEXT, a free open-source software for pupillometry, with an industrial camera. Pupil size was recorded simultaneously with both systems while illumination was provided by the Spark. Results show that neither pupillary response latencies nor amplit
Under rentier capitalism, class struggle extends beyond production, encompassing the entire process of value appropriation, circulation and distribution. Housing is a stark example. In post-war Nordic welfare states, organised labour played key roles in endorsing wide provision of affordable social housing. Today, workers are not only dominated as wage-labourers but also as tenants and debtors, st
We present PyeLink and SyeLink, two complementary open-source Python tools for running eye-tracking experiments and parsing data from SR Research Ltd. EyeLink eye tracking hardware. PyeLink simplifies experiment creation through plug-and-play support for multiple display backends (Pygame, PsychoPy, Pyglet) while enabling two features not available in existing tools: recording data during calibrati
BACKGROUND: In Sweden, approximately half of all individuals who die receive municipal care prior to death. Access to high-quality palliative care remains unequal, with known disparities between both care settings and diagnostic groups. Individuals receiving municipal home care are at higher risk of acute hospital admissions and in hospital death than those in long-term care facilities. However, t
Huvudsyftet med denna uppsats är att undersöka effekterna av aggressionsersättningsträning (ART) program på tre kriminalvårdsanstalter och två frivårdskontor. Huvudfrågeställningen som belyses i studien är: förändras deltagarna i ART-program med avseende på empati och attityder till kriminalitet? För att besvara dessa frågor har vi utfört för- och eftertester på tre kriminalvårdsanstalter och två
