Optimising diagnostic strategies for the early detection of Parkinson’s disease, using seed amplification assays
Background: Parkinson’s disease (PD) is the second most common neurodegenerative disease, and it is linked with aggregation of α-synuclein protein. PD can be diagnosed using real-time quaking induced conversion (RT-QuIC) assay. RT-QuIC, despite its effectiveness, is not really understood in terms of the mechanisms driving it. Aim(s): The aim of the project was to reproduce RT-QuIC protocol develop