Mechanisms underpinning recruitment of the HUSH-MORC2 corepressor to transposable elements in neural progenitor cells
The HUSH-MORC2 corepressor has emerged as a key player in epigenetic silencing of L1 retrotransposons and other mobile genetic elements during human development. In the ‘canonical’ mode of its recruitment to chromatin, HUSH makes interactions with nascent transcripts from target elements, leading to the assembly of SETDB1, which deposits the repressive heterochromatin mark H3K9me3, and chromatin r