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Added sugar intake and its associations with incidence of seven different cardiovascular diseases in 69,705 Swedish men and women

Introduction: The adverse health effects of sugar-sweetened beverage intake are well-established, but the implications of overall added sugar intake remain unclear. We investigated the associations between intake of added sugar and various sugar-sweetened foods and beverages and risk of 7 cardiovascular diseases in 69,705 participants aged 45–83 years (47.2% female) from the Swedish Mammography co

Future needs for continuing innovation in hemophilia : improving outcomes for individuals of all severities, including women and those in resource-constrained regions

Over recent decades, management of people with hemophilia (PwH) has been greatly improved by scientific advances that have resulted in a rich and varied therapeutic landscape. Nevertheless, treatment limitations continue to drive innovation, and emerging options have the potential to realize further improvement. We advocate four general principles to optimize benefits from innovation: individualiz

Association between the proportionality of functional mitral regurgitation and survival after mitral valve operation

Objective: The concept of proportionate and disproportionate functional mitral regurgitation suggests that transcatheter edge-to-edge mitral repair may benefit patients with a smaller left ventricle relative to a higher regurgitant burden. The clinical relevance of proportionality remains unknown in mitral operations for ischemic mitral regurgitation. We aimed to characterize the association betwe

An International Overview of Teaching Control Systems During COVID-19 Pandemic

This paper aims to provide an overview of the impact of the COVID-19 pandemic on control engineering education worldwide. The authors, who are educators in the control education field from various countries across all continents, first summarize their experiences to present a global perspective on the different solutions adopted in control education during the pandemic. Afterwards, collected infor

Complex Relationships between Diagnostics and Survival in Chronic Lymphocytic Leukemia in Denmark, Finland, Norway, and Sweden

Background: Chronic lymphocytic leukemia (CLL) is a common hematological malignancy with highly variable clinical presentation. Many patients never require any treatment but for the others, chemotherapy, immunochemotherapy, and newer targeted therapies have changed the treatment landscape. Diagnostic age influences the applied treatment, and we thus wanted to analyze age-specific survival trends t

The impact of periampullary diverticula on cannulation and adverse events in endoscopic retrograde cholangiopancreatography

Background: Periampullary diverticulum (PAD) is commonly encountered in endoscopic retrograde cholangiopancreatography (ERCP) procedures. Objectives: We sought to determine whether PADs are associated with a lower success rate of cannulation and an increased risk of adverse events. Design: A retrospective cohort study was conducted using prospectively gathered nationwide registry data. Methods: Us

Evaluation of Wildland Fire Detection Methods Using Expert Input

Recently the Intergovernmental Panel on Climate Change released their 6th Assessment reports which confirm that the impact of climate change is visible, e.g. through an increased weather volatility leading both to hotter drier weather and increased flooding in some regions globally. One clear example of this is the increased prevalence of wildfires in recent years and increasing wildfire potentialRecently the Intergovernmental Panel on Climate Change released their 6th Assessment reports which confirm that the impact of climate change is visible, e.g. through an increased weather volatility leading both to hotter drier weather and increased flooding in some regions globally. One clear example of this is the increased prevalence of wildfires in recent years and increasing wildfire potential

Naphthalene Decomposition on Fe(110)─Adsorption, Dehydrogenation, Surface Carbon Formation and the Influence of Coadsorbed Oxygen

Tar is an undesirable byproduct of biomass gasification, which can be removed through catalytic reforming to syngas components. Iron is a promising, abundant alternative to highly active but toxic nickel catalysts. The results observed so far in catalytic studies with iron have been mixed. In this paper, the decomposition of naphthalene, a representative model compound of tar, was studied on the c

Integrative analyses of circulating microRNA expression profile in hexavalent chromium exposed workers - A cross-sectional study within the SafeChrom project

Background Exposure to hexavalent chromium (Cr(VI)) can occur during occupational activities and leading lung cancer. MicroRNA (miRNA) plays an important part in carcinogenesis. Whether Cr(VI) exposure causes cancer-related miRNA changes is yet uncharacterized. Methods This study included 89 Cr(VI) exposed workers and 47 controls. MiRNAs were extracted from plasma followed by library preparations,

Assessing toxicity of PM2.5 from indoor sources and during exposure in private homes

Toxicological testing in mice was conducted on PM2.5 particles from stressed burning of two types of candles (white and blue) and on PM2.5 collected indoor and outdoor of fifteen occupied homes in southern Sweden. As an indicator of toxicity, the ability to generate Reactive Oxygen Species (ROS) was also assessed for all pooled samples: candle white, candle blue, indoor, and outdoor. Higher toxici

A comparison of approaches integrating power take-off systems into wave energy converters simulations

In the design of a wave energy converter (WEC) in general, one critical aspect is to develop thepower take-off (PTO) system since it has a significant impact on the overall energy harnessing efficiency. There-fore, the modelling of a PTO system should be considered in the simulation of a WEC and carefully tuned with itsparameters to guarantee prediction accuracy. However, it is a challenge to mode

A Swedish dietary guideline index, gut microbial α-diversity and prevalence of metabolic syndrome – observations in the Swedish CArdioPulmonary bioImage Study (SCAPIS)

Background: Metabolic syndrome (MetS) is characterized by coexisting risk factors for type 2 diabetes and cardiovascular disease. Diet is of importance in their aetiology, and gut microbiota (GM) may constitute a link between diet and metabolic health. Understanding the interplay between diet and GM could contribute novel insights for future dietary guidelines, and aid in preventive actions to mot

Recording of non-musculoskeletal manifestations, comorbidities and safety outcomes in European spondyloarthritis registries : A survey

Objectives: Real-world evidence is needed to inform treatment strategies for patients with PsA and axial SpA (axSpA) who have non-musculoskeletal manifestations (NMMs), various risk factors and comorbidities. International collaboration is required to ensure statistical power and to enhance generalizability. The first step forward is identifying which data are currently being collected. Across 17

Rimegepant for the acute and preventive treatment of migraine : a narrative review of the evidence

Introduction: Rimegepant is an oral small-molecule calcitonin gene-related peptide receptor antagonist approved in several countries for acute treatment of migraine and preventive treatment of episodic migraine in adults. This review summarizes the evidence, published to date, for the use of rimegepant as an acute or preventive treatment of migraine. Areas covered: A brief overview of migraine, th

Drug Treatment

A short review is given of current literature on medical alternatives for managing neurogenic bladder (NGB) by treating detrusor overactivity (NDO) and improving bladder compliance and urinary incontinence. The first goal of treatment of NGB is to protect the upper tract from damage, and the second is to maintain urinary continence, but all the while maintaining the patient’s quality of life. The

Thirteenth-Century Aristotelian Logic : The Study of Scientific Method

The aims of this paper are to show (i) that thirteenth-century Aristotelian logic (AL-13) is a logical tradition that considers Aristotelian logic (AL: the logical curriculum at the University of Paris, that is, Porphyry’s Isagoge, Aristotle’s Organon, Boethius’s De divisione and De topicis differentiis, and the anonymous Sex principia) as a system that is organized around the syllogistic argument

Self-reported physical activity more than 1 year after stroke and its determinants in relation to the WHO recommendations

BACKGROUND: Physical activity (PA) after stroke has significant health benefits if it is conducted regularly, with sufficient intensity and duration. Because of the health benefits, it is important to identify those below the World Health Organization (WHO) recommended level of PA. However, few studies have assessed the level of PA after stroke in relation to the WHO recommendations and which soci