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Effects of drying methods on physical properties and morphology of trehalose/mannitol mixtures

Solid-state properties of dried protein formulations are important for stability and functionality of the product. This study investigates how different drying technologies (freeze-drying with and without annealing, spray drying and spray-freeze drying) affect the structure and solid-state properties of a set of matrix formulations composed of trehalose (glass former) and mannitol (scaffolding age

Mathematical Modeling of Brain Circuitry during Cerebellar Movement Control

Reconstruction of movement control properties of the brain could result in many potential advantages for application in robotics. However, a hampering factor so far has been the lack of knowledge of the structure and function of brain circuitry in vivo during movement control. Much more detailed information has recently become available for the area of the cerebellum that controls arm-hand movemen

Context-specific functions of transcription factors controlling plant development : From leaves to flowers

Plant development is regulated by transcription factors that often act in more than one process and stage of development. Yet the molecular mechanisms that govern the functional diversity and specificity of these proteins remains far from understood. Flower development provides an ideal context to study these mechanisms since the development of distinct floral organs depends on similar but distinc

A nationwide evaluation of antibiotics consumption in Swedish intensive care units

Background: Around 70% of all ICU patients are treated with antibiotics whereas up to 30% are suggested as unnecessary. Measuring antibiotic consumption is a prerequisite to improving its use and the purpose of the present investigation was to explore the use of antibiotics in Swedish ICUs. Material and methods: Daily Defined Doses (DDDs) of antimicrobials delivered to Swedish ICUs, 2016–2018, wer

EXPERIMENTAL STUDY ON HEAT TRANSFER ENHANCEMENT OF AIR JET IMPINGEMENT FOR ELECTRONICS THERMAL MANAGEMENT

Jet impingement cooling was investigated on a flat heating surface placed in a flow channel, including single jet cooling, in-line double jet cooling, and combined crossflow and jet cooling; cross-flow cooling was a baseline for comparison. In addition, the in-line double jet cooling was explored with various jet distances. Local Nusselt number distribution was experimentally achieved by the liqui

Spinning forward and digging deeper : agency and changing institutions in old industrial regions

This paper highlights changes in perceived room for agency and local institutions (formal and informal) in old Swedish mill regions. The paper draws on recent literature on change agency (Grillitsch & Sotarauta, 2020) and reproductive agency (Bækkelund, 2021; Jolly et al., 2020) as well as the role of institutions in local communities (Bole, 2021; Rodríguez-Pose, 2013) and builds on material f

School nurses’ experiences of health-promoting work to prevent stress in Swedish adolescents

Aim: To investigate school nurses’ experiences of health-promoting work to prevent stress in Swedish adolescents. Materials and methods: Swedish school nurses (n = 225) responded to a web survey with open-ended questions. The results were subjected to a qualitative content analysis. Results: Six categories were identified from the analysis: (1) Knowledge of body and soul, (2) Identifying stress an

The genetic contribution to hand osteoarthritis

Objective: To estimate the genetic contribution to doctor-diagnosed hand osteoarthritis (OA). Methods: Using data from the Swedish Twin Registry and National Patient Register, we conducted a 20-year population-based longitudinal cohort study including 59,970 twins aged 35 years or older. We studied inpatient and outpatient doctor-diagnosed hand OA using ICD-10 codes from 1997 until 2016, including

Angular coefficients in W + j production at the LHC with high precision

The extraction of the W-boson mass, a fundamental parameter of the Standard Model, from hadron-hadron collision requires precise theory predictions. In this regard, angular coefficients are crucial to model the dynamics of W-boson production. In this work, we provide, for the first time, angular coefficients at NNLO QCD + NLO EW accuracy for finite transverse momentum W-boson at the LHC. The corre

Exponential approach to the hydrodynamic attractor in Yang-Mills kinetic theory

We use principal component analysis to study the hydrodynamic attractor in Yang-Mills kinetic theory undergoing the Bjorken expansion with color glass condensate initial conditions. The late-time hydrodynamic attractor is characterized by a single principal component determining the overall energy scale. How it is reached is governed by the disappearance of single subleading principal component ch

Patient factors associated with receiving reversal therapy in oral anticoagulant-related intracerebral hemorrhage

Background: We aimed to describe baseline characteristics of patients with oral anticoagulant-related intracerebral hemorrhage (OAC-ICH) in Sweden and to identify predictive variables associated with receiving hemostatic treatment in the event of OAC-ICH. Methods: We performed an observational study based on data from Riksstroke and the Swedish Causes of Death Register to define baseline character

Extending the Black diagram of bitumen to three dimensions

The ordinary Black diagram of bitumen has only two dimensions. Thus, it does not differentiate the complex shear modulus and phase angle measured under different temperature and frequency conditions. This study proposes to extend the Black diagram to three dimensions by adding a temperature axis. It leads to the combination of multiple necessary ordinary plots in the same three-dimensional (3D) sp

High-resolution HLA class II sequencing of Swedish multiple sclerosis patients

Multiple sclerosis (MS) is a chronic neurological disease believed to be caused by autoimmune pathogenesis. The aetiology is likely explained by a complex interplay between inherited and environmental factors. Genetic investigations into MS have been conducted for over 50 years, yielding >100 associations to date. Globally, the strongest linkage is with the human leukocyte antigen (HLA) HLA-DRB5*0

“It was a good… good, bad situation.” : Cameroonian fathers’ experiences of childbirth in Sweden

Introduction: In Sweden, partner's presence during childbirth is generally recommended. However, cultural values and norms in some immigrant societies can be an obstacle to this. Objective: To examine the experiences of Cameroonian fathers during their women's labour and childbirth in Sweden. Design: An exploratory qualitative study with semi-structured interviews were used for data collection and

A 5.8-GHz Rectifier Using Diode-Connected MESFET for Space Solar Power Satellite System

To improve the power handling capability at ground stations of a 5.8-GHz solar space power satellite using microwave power transmission, a power charge-pump meta-semiconductor field-effect transistor (MESFET)-based rectifier is presented in this article. Unlike conventional microwave Schottky diodes, diode-connected MESFETs, whose nonlinear characteristics help them to have a unique current&#x

Neurocognitive function following out-of-hospital cardiac arrest

Hjärtstopp inträffar när hjärtat plötsligt slutar slå och är ett livshotande tillstånd. Av personer som drabbas av hjärtstopp utanför sjukhus överlever endast en av tio fram till utskrivning från sjukhuset. Hjärnan har en hög ämnesomsättning och små energidepåer. Därför är hjärnan extra känslig för effekterna av ett hjärtstopp. När hjärtat slutar slå och blodet inte kan cirkulera i kroppen riskeraBackground: The brain is susceptible to hypoxic-ischemic brain injury in conjuction with out-of-hospital cardiac arrest (OHCA). Cognitive impairments are documented in about half of all OHCA survivors, however with a pronounced heterogeneity in measurements and findings. More detailed studies and instruments that are sensitive to OHCA-related cognitive impairment, including predictive models to id