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Personalizing progressive changes to brain structure in Alzheimer's disease using normative modeling

INTRODUCTION: Neuroanatomical normative modeling captures individual variability in Alzheimer's disease (AD). Here we used normative modeling to track individuals’ disease progression in people with mild cognitive impairment (MCI) and patients with AD. METHODS: Cortical and subcortical normative models were generated using healthy controls (n ≈ 58k). These models were used to calculate regional z

Characteristic Modes of Nonreciprocal Systems

The scattering formulation of characteristic mode decomposition is utilized to extend modal analysis to lossless scatterers breaking time-reversal symmetry. This enables characteristic modes analysis on devices containing gyrotropic or moving media. The resulting nonreciprocity introduces features not observed in reciprocal scenarios, such as asymmetric phase progression in characteristic far fiel

Thought for food : the endothermic brain hypothesis

The evolution of whole-body endothermy occurred independently in dinosaurs and mammals and was associated with some of the most significant neurocognitive shifts in life's history. These included a 20-fold increase in neurons and the evolution of new brain structures, supporting similar functions in both lineages. We propose the endothermic brain hypothesis, which holds that elaborations in endoth

European Union Normative Positions, Resilience and Contestation : A Perceptual Approach

Positioned within a perceptual approach to European Union (EU) foreign policy, this article explores tensions relating to the resilience of the EU's normative identity, focusing on factors and explanations external to the EU. We engage with EU perceptions amongst external partners theorized as active agents/potential contributors to contestation processes. We focus on the perceived role of the EU

Study of degradation mechanisms in aqueous-processed Ni-rich cathodes for enhanced sustainability of batteries

Traditionally, Ni-rich-layered oxide cathodes for lithium-ion batteries are produced utilizing N-methyl-2-pyrrolidone (NMP)-processed casting. However, to avoid using the reprotoxic solvent NMP, aqueous processing becomes one of the options. In this study, H2O-processed LiNi0.8Mn0.1Co0.1O2 (NMC811) electrodes have been prepared to compare with the NMP-processed counterparts to investigate the degr

Associations between misfolded alpha-synuclein aggregates and Alzheimer's disease pathology in vivo

INTRODUCTION: We examined the relations of misfolded alpha synuclein (α-synuclein) with Alzheimer's disease (AD) biomarkers in two large independent cohorts. METHODS: We included Biomarkers for Identifying Neurodegenerative Disorders Early and Reliably Two (BioFINDER-2) and Alzheimer's Disease Neuroimaging Initiative (ADNI) participants (n = 2315, cognitively unimpaired, mild cognitive impairment,

Subjective measurement of physical activity and sedentary behaviour in children and adolescents with cerebral palsy : a scoping review

Purpose: Physical activity is essential for maintaining overall health. Cost-effective and easily administered outcome instruments are valuable for clinical practice and large-scale population studies. The scoping review aimed to identify and map subjective instruments developed or validated to measure habitual physical activity and/or sedentary behaviour in children and adolescents with cerebral

CpG oligonucleotides induce acute murine thrombocytopenia dependent on toll-like receptor 9 and spleen tyrosine kinase pathways

Background: CpG oligonucleotides (ODNs) are synthetic single-stranded DNA sequences that act as immunostimulants. They have been increasingly used to treat several cancers; however, thrombocytopenia is a potential recognized side effect of some sequences. Objectives: We tested the ability of 2 CpG ODNs (ODN 2395 and ISIS 120704) to induce thrombocytopenia when administered to BALB/c mice and deter

Transitioning from an occupational therapy student to a clinically competent occupational therapist–A qualitative study

Background: The transition process from being an occupational therapy student to becoming an occupational therapist has been shown to be stressful, with an increased risk of burnout and job turnover. Consequently, there is a need to gain a deeper understanding of this process in order to identify ways of making it easier. Aims/objectives: To describe newly graduated Swedish occupational therapists

Fading Resilient Backscatter Communication : Low-Complexity Transmission, Detection and Synchronization Schemes

Battery-free IoT devices are becoming increasingly interesting for environmental and practical reasons, with ambient backscatter as one of the candidate technologies. We present a class of balanced transmission patterns for ambient backscatter communication (BSC) and evaluate their performance under different signal-to-interference ratios and fading conditions. These patterns allow for bit synchro

Nanocolumnar Metamaterial Platforms : Scaling Rules for Structural Parameters Revealed from Optical Anisotropy

Nanostructures represent a frontier where meticulous attention to the control and assessment of structural dimensions becomes a linchpin for their seamless integration into diverse technological applications. However, determining the critical dimensions and optical properties of nanostructures with precision still remains a challenging task. In this study, by using an integrative and comprehensive

Imaging evaluation focused on microstructural tissue changes using tensor-valued diffusion encoding in breast cancers after neoadjuvant chemotherapy : is it a promising way forward?

Background: Single diffusion encoding is a widely used, noninvasive technique for probing the tissue microstructure in breast tumors. However, it does not provide detailed information about the microenvironmental complexity. This study investigated the clinical utility of tensor-valued diffusion encoding for evaluating microstructural changes in breast cancer after neoadjuvant chemotherapy (NAC).