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Biocompatibility testing of medical devices is governed by the ISO 10993 series of standards and includes evaluation of skin sensitization potential of the final product. A majority of all medical devices are tested using in vivo methods, largely due to the lack of in vitro methods validated within the applicability domain of solid materials. The GARDskin method for assessment of chemical skin sen

Aim: Assess the prognostic ability of a non-highly malignant and reactive EEG to predict good outcome after cardiac arrest (CA). Methods: Prospective observational multicentre substudy of the “Targeted Hypothermia versus Targeted Normothermia after Out-of-hospital Cardiac Arrest Trial”, also known as the TTM2-trial. Presence or absence of highly malignant EEG patterns and EEG reactivity to externa

Warm dense matter is at the boundary between a plasma and a condensed phase and plays a role in astrophysics, planetary science and inertial confinement fusion research. However, its electronic structure and ionic structure upon irradiation with strong laser pulses remain poorly understood. Here, we use an intense and ultrafast X-ray free-electron laser pulse to simultaneously create and character

• Purpose: To assess utility, benefits, and risks of 4th-generation alumina–zirconia ceramic pairings in elective total hip arthroplasty (THA). • Methods: A comprehensive mixed-methods best-evidence synthesis using data from systematic reviews, randomized controlled trials (RCTs), prospective and retrospective cohort studies, as well as joint replacement registries, was conducted to estimate overa

Published in 1892, St. George Jackson Mivart’s remarkably original article ‘Happiness in Hell’ was placed on the Index Librorum Prohibitorum almost immediately. In his article, Mivart proposed a solution to the problem of hell whose core contention is that hell is horrible only from a heavenly point of view. From a this-worldly point of view, by contrast, hell is a place of breathtaking felicity. Published in 1892, St. George Jackson Mivart’s remarkably original article ‘Happiness in Hell’ was placed on the Index Librorum Prohibitorum almost immediately. In his article, Mivart proposed a solution to the problem of hell whose core contention is that hell is horrible only from a heavenly point of view. From a this-worldly point of view, by contrast, hell is a place of breathtaking felicity.

BackgroundThe curriculum for the courses given at the music specialization of theupper secondary school’s aesthetic program in Sweden includes theconcept of artistic expression (AE). Being a criterion for assessment, nodefinition is provided by the National Agency of Education and thereexists no consensus of how to interpret artistic expression amongmusic teachers and music teacher students.Method

Hur ska vi förstå att det pågår ett folkmord i realtid? Nina Gren hittar vägledning i filosofen Achille Mbembes teori nekropolitik som visar hur social och politisk makt används för att frånta rasifierade människor sitt värde. De blir levande döda.

Programmable optical circuits form a key part of quantum technologies today. As the size of such circuits is increased, maintaining precise control over every individual component becomes challenging. Here we show how embedding an optical circuit in the higher-dimensional space of a large mode-mixer allows us to forgo control over individual elements, while retaining a high degree of programmabili

This article contributes to a reconceptualization of the relationship between Siam and Scandinavia at the turn of the twentieth century. At that time, the relationship was manifested by the presence of a large group of Scandinavian, mainly Danish, entrepreneurs and professionals in Siam and repeated visits between the royal houses in Siam and the Scandinavian countries. The tropes of friendship an

In this article I discuss Lacans reading of Plato, especially in the middle seminars. I discuss how to evaluate Lacans understanding of Plato as a philosopher and how this might inspire us in our reading of Plato's works.

Environmental variation can shape the gut microbiome, but broad/large-scale data on among and within-population heterogeneity in the gut microbiome and the associated environmental factors of wild populations is lacking. Furthermore, previous studies have limited taxonomical coverage, and knowledge about wild avian gut microbiomes is still scarce. We investigated large-scale environmental variatio

Following the onset of the COVID-19 pandemic, an unprecedented use of mandatory lockdowns—defined as the imposition of at least one compulsory, non-pharmaceutical intervention—took place. We conduct a meta-analysis to determine the effect of these lockdowns on COVID-19 mortality. Our meta-analysis finds that lockdowns in the spring of 2020 had a relatively small effect on COVID-19 mortality and is

Thrombosis in myeloproliferative neoplasms (MPNs) is an important clinical problem, and risk-stratified management is essential. To identify the clinical characteristics of thrombosis in patients with MPNs, a nationwide multi-institutional retrospective analysis (JSH-MPN-R18) was conducted. The aim of the present study was to perform a sub-analysis of JSH-MPN-R18 findings to clarify the predictive

This research addresses action research (AR) as a meta-methodology and uses an operations development project as an illustration to provide some insights on AR as a meta-methodology. First, we report on a six-month action research (AR) project concerning analysing and improving production and inventory performance in an industrial firm in the food and beverage industry. The implementation of a new

This paper presents a comparison between a Itl-bit asynchronous SAR (ASAR) ADC and a 10-bit synchronous SAR (SSAR) ADC, both designed and simulated in a 22-nm FDSOI CMOS process. To further support the simulation results, the ASAR ADC has also been fabricated and measurements are pre-sented. As opposed to the abrupt SNDR collapse in the SSAR ADC, the SNDR of the ASAR ADC shows a more graceful deg-

This chapter focuses on industrialization and family behavior during the twentieth century against the backdrop of economic and institutional change. It documents trends regarding marriage and fertility and union dissolution from a gender perspective, and explores the role of socioeconomic status (SES) for these processes. Findings confirm patterns regarding gender and family consistent with that

We studied Rubus wahlbergii and related species in R. sect. Corylifolii, primarily in Sweden, using DNA microsatellites. The results show that the material can be divided into three species: R. wahlbergii s.s. which occurs along the Swedish coast from Bohuslän to Uppland, R. nordicus which occurs on the western coast all the way south to north-western Skåne, and a previously unrecognized taxon whi

The aim of the present European Stroke Organisation (ESO) guideline is to provide evidence-based recommendations on the acute management of patients with basilar artery occlusion (BAO). These guidelines were prepared following the Standard Operational Procedure of the ESO and according to the GRADE methodology. Although BAO accounts for only 1%–2% of all strokes, it has very poor natural outcome.