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Activating FLT3 and RAS mutations commonly occur in leukemia with KMT2A-gene rearrangements (KMT2A-r). However, how these mutations cooperate with the KMT2A-r to remodel the epigenetic landscape is unknown. Using a retroviral acute myeloid leukemia (AML) mouse model driven by KMT2A::MLLT3, we show that FLT3ITD, FLT3N676K, and NRASG12D remodeled the chromatin accessibility landscape and associated

Knowledge management is pivotal in innovation using mechanisms to facilitate knowledge exchange and learning among competitive tourism organisations and destinations. Nevertheless, both the tourism industry and its scholars have been slow to embrace the field leaving it relatively underdeveloped. Knowledge management, as a sequential process of capturing, developing, sharing, and leveraging from o

Identifying biomarkers in fibrotic lung disease is key for early anti-fibrotic intervention. Dynamic contrast-enhanced (DCE) MRI offers valuable perfusion-related insights in fibrosis but adapting human MRI methods to rodents poses challenges. Here, we explored these translational challenges for the inflammatory and fibrotic phase of a bleomycin lung injury model in rats. Eleven male Sprague-Dawle

A series of orthoborate-based ionic materials of bis(glycolato)borate ([BGB]) and bis(ethylene-1,2-dioxy)borate anions ([BEDB]) coupled with tetrabutylphosphonium ([P4444]) and tetrabutylammonium ([N4444]) cations have been synthesized, and their physicochemical properties are characterized. The ionic materials based on the most popular orthoborate anion, bis(oxalato)borate anion ([BOB]), which co

Human monocarboxylate transporters (hMCTs) belong to the solute carrier 16 (SLC16) family of proteins and are responsible for the bi-directional transport of various metabolites, including monocarboxylates, hormones, and aromatic amino acids. Hence, the metabolic role of hMCTs is undisputable, as they are directly involved in providing nutrients for oxidation and gluconeogenesis as well as partici

Introduction: Preterm delivery (PTD) is the leading cause of death in children under 5 years of age. Cervical shortening detected by ultrasound can be used to predict PTD, but prediction is not perfect, and complementary diagnostic markers are needed. Recently, specific plasma microribonucleic acid (miRNAs) detected in early second trimester were shown to be associated with spontaneous PTD in high

Biodiversity records are of great importance, especially in light of the biodiversity crisis. Here, we present a study on the diversity of rotifers in Bolivia based on an extensive investigation of the literature published so far. Through this approach and an analysis of samples from 207 water bodies of the country, we updated the checklist of reported species. This study revealed a total of 195 s

Situation awareness in driving involves detection of events and environmental changes. Failure in detection can be attributed to the density of these events in time, amongst other factors. In this research, we explore the effect of temporal proximity, and event duration in a change detection task during driving in VR. We replicate real-world interaction events in the streetscape and systematically

Tourism is consistently affected by a change. Whether it be economic, social, and cultural, or whether it be technological and environmental, which are the focus of much contemporary tourism scholarship. Furthermore, change occurs at different scales and is uneven over space and time. Therefore, while all change is experienced locally, global overviews such as that provided in this book can only p

Context. Star clusters, composed of stars born from the same molecular cloud, serve as invaluable natural laboratories for understanding the fundamental processes governing stellar formation and evolution. Aims. This study aims to investigate correlations between the Mean Interdistance (Di), Mean Closest Interdistance (Dc) and Median Weighted Central Interdistance (Dcc) with the age of star cluste

To steer the economy towards a low-carbon future and mitigate climate change, the European Union Emissions Trading System (EU ETS) has been established at the European level. It operates through a cap-and-trade mechanism and currently regulates around 40% of the EU’s CO2 emissions. However, due to regional differences in the industry mix and the spatial concentration of regulated industrial instal

How do the limits of high-level visual processing affect human performance in naturalistic, dynamic settings of (multimodal) interaction where observers can draw on experience to strategically adapt attention to familiar forms of complexity? In this backdrop, we investigate change detection in a driving context to study attentional allocation aimed at overcoming environmental complexity and tempor

Herein, the first example of a homoleptic AgIII complex stabilized by a monodentate N-donor ligand is presented. Na2[S2O8] oxidizes the linear AgI complex, Na[Ag(succ)2] (1Na), to form a square planar argentate(III) ion, [Ag(succ)4]–, which crystallizes with a polymeric chain-structure, M[Ag(succ)4] (2M), when treated with alkali metal sulfate M2SO4 (M = K, Rb, Cs). A mixed-valent Robin-Day class

The first authoritative overview of tourism studies published post-COVID-19 The Wiley Blackwell Companion to Tourism remains a definitive reference in this interdisciplinary field. Edited and authored by leading scholars from around the world, this state-of-the-art volume provides a comprehensive critical overview of tourism studies across the social sciences. In-depth yet accessible chapters comb

We develop a cognitive evaluation schema for analysing the diversity and nuances of visuospatial complexity and multimodal interactions encountered in naturalistic everyday driving conditions. The proposed schema is based on a finegrained empirical analysis of real-world everyday driving situations involving stakeholders such as drivers, pedestrians, cyclists. Our method involves a semantic analys

Obesity is a risk factor for cardio-metabolic and neurological disease. The contribution of gut microbiota to derangements of the gut-brain axis in the context of obesity has been acknowledged, particularly through physiology modulation by short-chain fatty acids (SCFAs). Thus, probiotic interventions and administration of SCFAs have been employed with the purpose of alleviating symptoms in both m