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Cognitive behavioral group treatment for low self-esteem in psychosis : a proof of concept study

Background: Patients with a psychotic disorder often suffer from low self-esteem, which has been related to higher suicidal risk, poor quality of life and, the maintenance of psychotic and depression symptoms. However, intervention studies are scarce and reported interventions concern individual therapies provided by highly educated psychologists. Both the individual setting and the required quali

Effect of virtual reality exposure therapy on social participation in people with a psychotic disorder (VRETp) : Study protocol for a randomized controlled trial

Background: Many patients with a psychotic disorder participate poorly in society. When psychotic disorders are in partial remission, feelings of paranoia, delusions of reference, social anxiety and self-stigmatization often remain at diminished severity and may lead to avoidance of places and people. Virtual reality exposure therapy (VRET) is an evidence-based treatment for several anxiety disord

Dynamic Interactive Social Cognition Training in Virtual Reality (DiSCoVR) for social cognition and social functioning in people with a psychotic disorder : study protocol for a multicenter randomized controlled trial

BACKGROUND: Problems in social functioning (e.g., unemployment, social isolation), are common in people with a psychotic disorder. Social cognition is a treatment target to improve social functioning, as it is a proximal predictor of social functioning. Social Cognition Training (SCT) improves social cognition, but may not generalize (enduringly) to social functioning, perhaps due to insufficient

Daily-life stress reactivity and recovery following virtual-reality-based cognitive behavioral therapy in patients with a psychotic disorder

Introduction: Studies have consistently demonstrated increased stress sensitivity in individuals with psychosis. Since stress sensitivity may play a role in the onset and maintenance of psychosis, this could potentially be a promising target for treatment. The current study was the first to investigate whether reactivity to and recovery from daily-life stressors in psychosis change in response to

Virtual reality-based cognitive behavioural therapy for patients with generalized social anxiety disorder : A pilot study

Background: Patients with generalized social anxiety disorder (SAD) avoid various social situations and can be reluctant to engage in in vivo exposure therapy. Highly personalized practising can be required before patients are ready to perform in vivo exposure. Virtual reality-based therapy could be beneficial for this group.Aims: To assess the feasibility and potential effect of virtual reality-b

Properties and units in the clinical laboratory sciences. Part XXVIII. NPU codes for characterizing subpopulations of the hematopoietic lineage, described from their clusters of differentiation molecules (IUPAC Technical Report)

This document describes how the Nomenclature for Properties and Units (NPU) terminology can be applied to differentiate between cell subpopulations of the hematopoietic lineage. The clusters of differentiation molecules are included in the NPU syntax, together with its correct affiliations to indicate their presence or absence. This allows for identification and isolation of cell populations, subs

Social environments and interpersonal distance regulation in psychosis : A virtual reality study

Background: Experimentally studying the influence of social environments on mental health and behavior is challenging, as social context is difficult to standardize in laboratory settings. Virtual Reality (VR) enables studying social interaction in terms of interpersonal distance in a more ecologically valid manner. Regulation of interpersonal distance may be abnormal in patients with psychotic di

Longitudinal clinical and functional outcome in distinct cognitive subgroups of first-episode psychosis : A cluster analysis

Background Cognitive deficits may be characteristic for only a subgroup of first-episode psychosis (FEP) and the link with clinical and functional outcomes is less profound than previously thought. This study aimed to identify cognitive subgroups in a large sample of FEP using a clustering approach with healthy controls as a reference group, subsequently linking cognitive subgroups to clinical and

Exploring the role of clinical and demographic characteristics on the effects of virtual reality cognitive behavioral therapy for psychosis : A moderator analysis

Background: Virtual Reality cognitive behavioral therapy (VR-CBT) has proven to be an effective treatment method for paranoia and anxiety in psychosis. However, it is unknown, which individuals benefit most from VR-CBT. Previous studies examined factors affecting the treatment effect of regular CBTp, including illness duration, paranoia, depression, and pre-therapy avoidance behaviors, but results

Dynamic Interactive Social Cognition Training in Virtual Reality (DiSCoVR) versus Virtual Reality Relaxation (VRelax) for People with a Psychotic Disorder : A Single-Blind Multicenter Randomized Controlled Trial

Background and Hypothesis: Social cognition training (SCT), an intervention for social cognition and social functioning, might be improved by using virtual reality (VR), because VR may offer better opportunities to practice in a potentially more realistic environment. To date, no controlled studies have investigated VR-SCT. This study investigated a VR-SCT, "DiSCoVR". We hypothesized that DiSCoVR

Virtual Reality Aggression Prevention Training for People with Mild Intellectual Disabilities : A Feasibility Study

Introduction: Problems with adequately regulating aggression are comon in people with mild to borderline intellectual disabilities (MBID). Learning through experience has been shown to be effective in MBID. Therefore, we adapted an aggression prevention training that uses virtual reality (VR), which was initially made for a forensic psychiatric population. We aimed to assess the feasibility of thi

To continue or not to continue? Antipsychotic medication maintenance versus dose-reduction/discontinuation in first episode psychosis : HAMLETT, a pragmatic multicenter single-blind randomized controlled trial

Background: Antipsychotic medication is effective for symptomatic treatment in schizophrenia-spectrum disorders. After symptom remission, continuation of antipsychotic treatment is associated with lower relapse rates and lower symptom severity compared to dose reduction/discontinuation. Therefore, most guidelines recommend continuation of treatment with antipsychotic medication for at least 1 year

Medication strategies in first episode psychosis patients : A survey among psychiatrists

Aim: There is an ongoing debate regarding the optimal timing of discontinuation of antipsychotic drugs for patients with first episode psychosis. Although most guidelines recommend maintenance therapy for at least 1 or 2 years after reaching remission, study results indicate that early discontinuation may be beneficial for at least a subsample of patients. To date, little is known about which medi

Rescaling : Change agency and the emerging geography of economic relationships

In this paper, we propose a theoretical and conceptual framework for articulating and studying changes in the global economic landscape and illustrate this framework in the current context. The framework pivots around the notion of rescaling, which is interpreted from a human agency perspective. We disentangle three theoretically distinct dimensions of rescaling and show how they play together usi

Asthma and allergy trajectories in children based on combined parental report and register data

Background: Trajectories of asthma and allergy in children are heterogeneous and commonly derived from parental report of disease or clinical records. This study combined parental-reported and register-based dispensed medication data to characterize childhood trajectories of co-existing asthma, allergic rhinitis, and eczema. Methods: From a Swedish population-based birth cohort (N = 5654), survey

The Effect of Military Base Closures on Young Adults

This study examines the response among young adults to the closure of a large local employer. By using military base closures in Sweden, I find that men experience lower earnings and enroll in tertiary education. This is driven by low-ability men who choose shortterm enrollment at nearby colleges and universities. For women, the closures have a positive impact after some years, with increases in b

50 år av folksuveränitet. Makt, funktion och ­förvaltning i 1974 års regeringsform

År 2024 är det 50 år sedan riksdagen slutligt beslutade att införa den nuvarande regeringsformen. Jubileet har fått relativt mycket uppmärksamhet. Riksdagen har byggt upp en särskild webbplats med information och det har givits ut minst tre forskningsantologier med anledning av jubileet.I detta temanummer ger statsvetare och jurister sina perspektiv på centrala teman med anknytning till den nu fem

Kommentar. Regeringsformen och de statliga lärosätena

Shirin Ahlbäck Öberg belyser i sin artikel i detta nummer av Statsvetenskaplig tidskrift några viktiga aspekter av hur lärosätenas konstitutionella ställning har utvecklats fram till 1974 års regeringsform och därefter. I ett större perspektiv visar hennes bidrag också på några allmänna drag i regeringsformens tillkomst och betydelse för den offentliga verksamheten. I denna kommentar ger jag några