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Quantitative analysis of redox proteome reveals oxidation-sensitive protein thiols acting in fundamental processes of developmental hematopoiesis

Fetal and adult hematopoietic stem and progenitor cells (HSPCs) are characterized by distinct redox homeostasis that may influence their differential cellular behavior in normal and malignant hematopoiesis. In this work, we have applied a quantitative mass spectrometry-based redox proteomic approach to comprehensively describe reversible cysteine modifications in primary mouse fetal and adult HSPC

The political economy of degrowth

What is degrowth and what are its implications for political economy? Divided in three parts, this dissertation explores the why, what, and how of degrowth.The first part (Of growth and limits) studies the nature, causes, and consequences of economic growth. Chapter 1: Understanding economic growth answers a series of questions about the nature of economic growth: What is it exactly that grows? By

Exploring degrowth policy proposals: A systematic mapping with thematic synthesis

Degrowth – the planned and democratic reduction of production and consumption as a solution to the social-ecological crises – is slowly making its way to the sphere of policy-making. But there is a problem: proposals are scattered through a voluminous literature, making it difficult for decision-makers to pinpoint the concrete changes associated with the idea of degrowth. To address this issue, we

Bacterial and fungal communities in tracheal aspirates of intubated COVID-19 patients : a pilot study

Co-infections with bacterial or fungal pathogens could be associated with severity and outcome of disease in COVID-19 patients. We, therefore, used a 16S and ITS-based sequencing approach to assess the biomass and composition of the bacterial and fungal communities in endotracheal aspirates of intubated COVID-19 patients. Our method combines information on bacterial and fungal biomass with communi